Amino acid metabolism pathway excerpt: histidine catabolism extension (Homo sapiens)
From WikiPathways
Description
This pathway was created based on findings from the bachelor thesis (DOI: COMING!) project by Kristin Koppelmaa which investigated vitamin D GWAS results.
This pathway shows an excerpt of the WikiPathways amino acid metabolism (WP3925) pathway containing the segment between the metabolites histidine and glutamate that was extended. The proteins added to the conversion were AMDHD1 and UROC1. Although the HAL and FTCD proteins were included in the amino acid metabolism pathway previously, the lead SNP rs7487782 which exists in both HAL and AMDHD1, was added to the pathway and linked to these two genes. This variant was mapped to these genes during the analysis of a dataset originating from a study which has the PubMed ID: 29343764.
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Ontology Terms
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- Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP; ''''; , PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2-oxo-glutarate | Metabolite | 16810 (ChEBI)  | |
| 4I-5PROA | Metabolite | CHEBI:27384 (ChEBI) | trans-urocanic acid |
| AMDHD1 | GeneProduct | Q96NU7 (Uniprot-TrEMBL) | |
| Aconitate | Metabolite | HMDB00072 (HMDB) | |
| Alanine | Metabolite | HMDB00161 (HMDB) | |
| Citrate | Metabolite | HMDB00094 (HMDB) | |
| FTCD | GeneProduct | ENSG00000160282 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962 |
| Fumarate | Metabolite | HMDB00134 (HMDB) | |
| GLUD1 | GeneProduct | ENSG00000148672 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753 |
| GPT2 | GeneProduct | ENSG00000166123 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391 |
| Glutamate | Metabolite | HMDB00148 (HMDB) | |
| HAL | GeneProduct | ENSG00000084110 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010 |
| Histidine | Metabolite | HMDB00177 (HMDB) | |
| Malate | Metabolite | HMDB00156 (HMDB) | |
| NF-Glu | Metabolite | CHEBI:18327 (ChEBI) | trans-urocanic acid |
| Oxaloacetate | Metabolite | HMDB00223 (HMDB) | |
| Pyruvate | Metabolite | HMDB00243 (HMDB) | |
| Succinate | Metabolite | HMDB00254 (HMDB) | |
| Succinyl-CoA | Metabolite | HMDB01022 (HMDB) | |
| UCA | Metabolite | CHEBI:30817 (ChEBI) | trans-urocanic acid |
| UROC1 | GeneProduct | Q96N76 (Uniprot-TrEMBL) | Dimer with NAD+ |
| isocitrate | Metabolite | HMDB00193 (HMDB) |
Annotated Interactions
No annotated interactions
