ATR signaling (Homo sapiens)
From WikiPathways
Description
This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress.
This pathway is part the CPTAC Assay Portal.
Quality Tags
Ontology Terms
Saving...Bibliography
- Nam EA, Cortez D; ''ATR signalling: more than meeting at the fork.''; Biochem J, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ATR | GeneProduct | ENSG00000175054 (Ensembl)  | |
| ATRIP | GeneProduct | ENSG00000164053 (Ensembl) | |
| CHK1 | GeneProduct | ENSG00000149554 (Ensembl) | |
| HUS1 | GeneProduct | ENSG00000136273 (Ensembl) | |
| RAD1 | GeneProduct | ENSG00000113456 (Ensembl) | |
| RAD9A | GeneProduct | ENSG00000172613 (Ensembl) | |
| RAD9B | GeneProduct | ENSG00000151164 (Ensembl) | |
| RPA | GeneProduct | ENSG00000132383 (Ensembl) | |
| TOPBP1 | GeneProduct | ENSG00000163781 (Ensembl) |
Annotated Interactions
No annotated interactions
