Histidine, purine, and pyrimidine superpathway (Saccharomyces cerevisiae)
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THF
CO2
5-phosphoribosyl-n-formylglycineamidine
UMP
carbamoyl-L-aspartate
reduced thioredoxin
L-aspartate
H2O
HCO3
carbamoyl-phosphate
H2O
THF
oxidized flavodoxin
orotate
H2O
H2O
fumerate
H2O
phosphoribosyl-ATP
5’-phosphoribosyl-N-formylglycineamide
H+
histidinol
H2O
phosphoribosyl-AMP
phosphoribosyl-formamido-carboxamide
H2O
reduced acceptor
5’-phosphoribosyl-5-aminoimidazole
UDP
H2O
5-phospho-ribosyl-glycineamide
AMP
AMP
CTP
imidazole acetol-phosphate
NAD
H2O
H+
reduced flavodoxin
H2O
D-erythro-imidazole-glycerol-phosphate
2-oxoglutarate
CO2
NH3
NAD
H2O
orotidine-5’-phosphate
sucinocarboxamide)-5-aminoimidazole
phosphoribosylformiminoAICAR-phosphate
5-phosphoribosylamine
phosphoribosyl-carboxy-aminoimidazole
H2O
L-aspartate
H2O
H+
H2O
UTP
IMP
acceptor
histidinal
5’-phosphoribosyl-4-(N-
oxidized thioredoxin
H2O
H2O
NAD
phosphoribulosylformimino-AICAR-P
AMP
dihydroorotate
deoxy-GTP
ADE17
phosphate
IMD4
YNK1
L-glutamate
RNR3
L-glutamate
phosphate
PRS3
dGDP
HIS3
HIS4
pyrophosphate
GTP
ADE16
10-formyl-THF
ADP
GDP
pyrophosphate
ADE17
URA5
ATP
ADP
phosphate
HIS4
ADP
ADP
L-glutamate
L-glutamine
ATP
pyrophosphate
RNR1
ATP
ATP
YNK1
ATP
ATP
ADE5,7
URA10
ADP
phosphate
L-histidine
ADE4
PRS2
ADP
ADP
ADP
HIS4
GUA1
D-ribose-5-phosphate
L-glycine
ATP
ADP
URA6
ADE2
HIS2
ATP
PRPP
URA8
L-histidinol-phosphate
HIS6
ADE13
2 ATP
PRS5
RNR4
URA3
NADH
10-formyl-THF
GMP
phosphate
ATP
ADE1
AICAR
ATP
ATP
L-glutamine
URA7
ADE5,7
phosphate
pyrophosphate
RNR2
L-glutamate
L-glutamine
HIS4
ATP
ADE16
2 ADP
ATP
phosphate
HIS1
L-glutamate
ADE6
CDP
L-glutamine
pyrophosphate
HIS5
ATP
ADP
NADH
ADP
L-glutamate
GUK1
URA1
ADP
L-glutamate
IMD3
phosphate
URA2
xanthosine-5-phosphate
PRS1
ATP
phosphate
URA2
URA4
NADH
ATP
IMD2
ADE8
PRS4
L-glutamine
L-glutamine
phosphate
Description
No description
Comments
GenMAPP remarks
Based on
http://pathway.yeastgenome.org/biocyc/
Try the New WikiPathways
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Quality Tags
Ontology Terms
Saving...
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Bibliography
''Histidine, purine, and pyrimidine superpathway''; YeastPathways,
History
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Compare
Revision
Action
Time
User
Comment
135544
view
20:00, 23 September 2024
Khanspers
Modified description
135448
view
21:58, 5 September 2024
Khanspers
Ontology Term : 'classic metabolic pathway' added !
135447
view
21:58, 5 September 2024
Khanspers
removed GenMAPP comments
135446
view
21:57, 5 September 2024
Khanspers
135445
view
21:56, 5 September 2024
Khanspers
lit ref
135314
view
00:05, 17 August 2024
Khanspers
interactions
122754
view
05:17, 10 May 2022
Egonw
Added identifiers to water nodes
117345
view
11:53, 20 May 2021
Eweitz
Modified title
107259
view
14:35, 17 September 2019
MaintBot
ChEBI identifier normalization
94664
view
13:18, 4 October 2017
DeSl
Changed ribose-5-P label to D-ribose-5-P
94663
view
13:17, 4 October 2017
DeSl
Connected all lines, changed all textlabels to metabolite nodes, connected all genes to the lines.
93079
view
09:22, 28 July 2017
Elisa
Fixed some of the unconnected interactions (left side of the pathway).
93011
view
14:46, 24 July 2017
DeSl
Changed wrong CAS number (salt) for correct ChEBI ID
85638
view
16:11, 4 June 2016
Egonw
Fixed the CAS number.
71897
view
10:35, 22 October 2013
Mkutmon
changed AICAR from Unknown to Metabolite
70270
view
21:50, 15 July 2013
MaintBot
updated to 2013 schema
69872
view
18:00, 11 July 2013
Egonw
Marked a few DataNodes with CAS registry numbers as metabolites.
67670
view
11:47, 26 June 2013
Ddigles
Ontology Term : 'nucleotide metabolic pathway' added !
41803
view
04:48, 2 March 2011
MaintBot
Removed redundant pathway information and comments
21558
view
11:32, 14 November 2008
MaintBot
[[Pathway:Saccharomyces cerevisiae:Superpathway of Histidine Purine and Pyrimidine Biosynthesis]] moved to [[Pathway:WP416]]: Moved to stable identifier
12861
view
08:06, 17 May 2008
MaintBot
automated metabolite conversion
8948
view
14:13, 7 January 2008
MaintBot
Added to category $category
8946
view
14:13, 7 January 2008
M.Braymer
Uploaded new pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
10-formyl-THF
Metabolite
2800-34-2 (CAS)
2 ADP
Metabolite
58-64-0 (CAS)
2 ATP
Metabolite
1927-31-7 (CAS)
2-oxoglutarate
Metabolite
5-phospho-ribosyl-glycineamide
Metabolite
5-phosphoribosyl-n-formylglycineamidine
Metabolite
5-phosphoribosylamine
Metabolite
5’-phosphoribosyl-4-(N-
Metabolite
5’-phosphoribosyl-5-aminoimidazole
Metabolite
5’-phosphoribosyl-N-formylglycineamide
Metabolite
ADE13
GeneProduct
S000004351 (SGD)
ADE16
GeneProduct
S000004018 (SGD)
ADE17
GeneProduct
S000004727 (SGD)
ADE1
GeneProduct
S000000070 (SGD)
ADE2
GeneProduct
S000005654 (SGD)
ADE4
GeneProduct
S000004915 (SGD)
ADE5,7
GeneProduct
S000003203 (SGD)
ADE6
GeneProduct
S000003293 (SGD)
ADE8
GeneProduct
S000002816 (SGD)
ADP
Metabolite
58-64-0 (CAS)
AICAR
Metabolite
3031-94-5 (CAS)
AMP
Metabolite
ATP
Metabolite
1927-31-7 (CAS)
CDP
Metabolite
63-38-7 (CAS)
CO2
Metabolite
CTP
Metabolite
D-erythro-imidazole-glycerol-phosphate
Metabolite
D-ribose-5-phosphate
Metabolite
3615-55-2 (CAS)
GDP
Metabolite
146-91-8 (CAS)
GMP
Metabolite
85-32-5 (CAS)
GTP
Metabolite
2564-35-4 (CAS)
GUA1
GeneProduct
S000004830 (SGD)
GUK1
GeneProduct
S000001550 (SGD)
H+
Metabolite
H2O
Metabolite
HCO3
Metabolite
HIS1
GeneProduct
S000000857 (SGD)
HIS2
GeneProduct
S000001921 (SGD)
HIS3
GeneProduct
S000005728 (SGD)
HIS4
GeneProduct
S000000535 (SGD)
HIS5
GeneProduct
S000001378 (SGD)
HIS6
GeneProduct
S000001282 (SGD)
IMD2
GeneProduct
S000001259 (SGD)
IMD3
GeneProduct
S000004424 (SGD)
IMD4
GeneProduct
S000004520 (SGD)
IMP
Metabolite
L-aspartate
Metabolite
L-glutamate
Metabolite
56-86-0 (CAS)
L-glutamine
Metabolite
56-85-9 (CAS)
L-glycine
Metabolite
56-40-6 (CAS)
L-histidine
Metabolite
71-00-1 (CAS)
L-histidinol-phosphate
Metabolite
25679-93-0 (CAS)
NAD
Metabolite
NADH
Metabolite
53-84-9 (CAS)
NH3
Metabolite
PRPP
Metabolite
97-55-2 (CAS)
PRS1
GeneProduct
S000001664 (SGD)
PRS2
GeneProduct
S000000901 (SGD)
PRS3
GeneProduct
S000001003 (SGD)
PRS4
GeneProduct
S000000164 (SGD)
PRS5
GeneProduct
S000005422 (SGD)
RNR1
GeneProduct
S000000872 (SGD)
RNR2
GeneProduct
S000003563 (SGD)
RNR3
GeneProduct
S000001328 (SGD)
RNR4
GeneProduct
S000003412 (SGD)
THF
Metabolite
UDP
Metabolite
UMP
Metabolite
URA10
GeneProduct
S000004884 (SGD)
URA1
GeneProduct
S000001699 (SGD)
URA2
GeneProduct
S000003666 (SGD)
URA3
GeneProduct
S000000747 (SGD)
URA4
GeneProduct
S000004412 (SGD)
URA5
GeneProduct
S000004574 (SGD)
URA6
GeneProduct
S000001507 (SGD)
URA7
GeneProduct
S000000135 (SGD)
URA8
GeneProduct
S000003864 (SGD)
UTP
Metabolite
YNK1
GeneProduct
S000001550 (SGD)
carbamoyl-L-aspartate
Metabolite
carbamoyl-phosphate
Metabolite
dGDP
Metabolite
CHEBI:28862 (ChEBI)
deoxy-GTP
Metabolite
dihydroorotate
Metabolite
fumerate
Metabolite
histidinal
Metabolite
histidinol
Metabolite
imidazole acetol-phosphate
Metabolite
orotate
Metabolite
orotidine-5’-phosphate
Metabolite
oxidized flavodoxin
Metabolite
oxidized thioredoxin
Metabolite
phosphate
Metabolite
14265-44-2 (CAS)
phosphoribosyl-AMP
Metabolite
phosphoribosyl-ATP
Metabolite
phosphoribosyl-carboxy-aminoimidazole
Metabolite
phosphoribosyl-formamido-carboxamide
Metabolite
phosphoribosylformiminoAICAR-phosphate
Metabolite
phosphoribulosylformimino-AICAR-P
Metabolite
pyrophosphate
Metabolite
2466-09-3 (CAS)
reduced flavodoxin
Metabolite
reduced thioredoxin
Metabolite
sucinocarboxamide)-5-aminoimidazole
Metabolite
xanthosine-5-phosphate
Metabolite
523-98-8 (CAS)
Annotated Interactions
No annotated interactions
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Annotated Interactions
No annotated interactions