Omega-9 fatty acid synthesis (Homo sapiens)

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12SCD5FASNACSL1FADS13CoA(20:0)Lauric acidMyristic acidCoA(16:0)CoA(16:1(9Z))CoA(18:1(9Z))CoA(18:2(6Z,9Z))CoA(20:1(11Z))CoA(20:2(8Z,11Z))18:2(6Z,9Z)Stearic acid16:1(9Z)CoA(18:0)Palmitic acidACSL3ACSL4ELOVL2ELOVL5ELOVL6ELOVL3CoA(22:0)CoA(24:0)ELOVL1CoA(26:0)Arachidic acidBehenic acidLignoceric acidCerotic acidCoA(22:1(13Z))CoA(24:1(15Z))hSCD120:2(8Z,11Z)CoA(20:3(5Z,8Z,11Z))20:3(5Z,8Z,11Z)FADS2Oleic acidAcot1ACOT2Acot124:1(15Z))cis-erucic acid


Description

This pathway is inspired by the Lipidmaps>Omega-9 and other fatty acids [1].

Omega-9 FAs (Fatty acids) are fats which can be obtained from diet, but also produced endogenously. These lipids are monounsaturated (indicating one double bonds in the lipid tail).The position of the double bond is counted from the tail end of the lipid chain.

This pathway also indicated saturated fats (without a double bond), such as stearic acid, arachidic acid etc.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4351_106337.gpml] with a 80.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Zhang S, Yang Y, Shi Y; ''Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.''; Biochem J, 2005 PubMed Europe PMC Scholia
  3. Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G; ''Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
124741view08:48, 8 December 2022DeSlUpdate links to LIPID MAPS PWs
117812view14:46, 22 May 2021EweitzModified title
107608view09:59, 24 October 2019DeSlChanged Scd2 (mouse) to corresponding Human orthologs (hSCD1 and SCD5), with lit. refs.
107601view15:20, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16:1(9Z)MetaboliteLMFA01030056 (LIPID MAPS)
18:2(6Z,9Z)MetaboliteLMFA07050060 (LIPID MAPS)
20:2(8Z,11Z)MetaboliteLMFA01030377 (LIPID MAPS)
20:3(5Z,8Z,11Z)MetaboliteLMFA01030381 (LIPID MAPS)
24:1(15Z))MetaboliteLMFA01030377 (LIPID MAPS) AKA cis-selacholeic acid
ACOT2GeneProductENSG00000119673 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
ACSL1GeneProductENSG00000151726 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ACSL3GeneProductENSG00000123983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
ACSL4GeneProductENSG00000068366 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
Acot1GeneProductNo homologues found for original id L:26897
Arachidic acidMetaboliteLMFA01010020 (LIPID MAPS)
Behenic acidMetaboliteLMFA01010022 (LIPID MAPS)
Cerotic acidMetaboliteLMFA01010026 (LIPID MAPS)
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(16:1(9Z))MetaboliteLMFA07050359 (LIPID MAPS)
CoA(18:0)MetaboliteLMFA07050369 (LIPID MAPS)
CoA(18:1(9Z))MetaboliteLMFA07050356 (LIPID MAPS)
CoA(18:2(6Z,9Z))MetaboliteLMFA07050060 (LIPID MAPS)
CoA(20:0)MetaboliteLMFA07050329 (LIPID MAPS)
CoA(20:1(11Z))MetaboliteLMFA07050093 (LIPID MAPS)
CoA(20:2(8Z,11Z))MetaboliteLMFA07050061 (LIPID MAPS)
CoA(20:3(5Z,8Z,11Z))MetaboliteLMFA07050062 (LIPID MAPS)
CoA(22:0)MetaboliteLMFA07050289 (LIPID MAPS)
CoA(22:1(13Z))MetaboliteLMFA07050318 (LIPID MAPS)
CoA(24:0)MetaboliteLMFA07050372 (LIPID MAPS)
CoA(24:1(15Z))MetaboliteLMFA07050098 (LIPID MAPS)
CoA(26:0)MetaboliteLMFA07050327 (LIPID MAPS)
ELOVL1GeneProductENSG00000066322 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54325
ELOVL2GeneProductENSG00000197977 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
ELOVL3GeneProductENSG00000119915 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12686
ELOVL5GeneProductENSG00000012660 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
ELOVL6GeneProductENSG00000170522 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:170439
FADS1GeneProductENSG00000149485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
FADS2GeneProductENSG00000134824 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
FASNGeneProductENSG00000169710 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14104
Lauric acidMetaboliteLMFA01010012 (LIPID MAPS)
Lignoceric acidMetaboliteLMFA01010024 (LIPID MAPS)
Myristic acidMetaboliteLMFA01010014 (LIPID MAPS)
Oleic acidMetaboliteLMFA01030002 (LIPID MAPS)
Palmitic acidMetaboliteLMFA01010001 (LIPID MAPS)
SCD5ProteinQ86SK9 (Uniprot-TrEMBL)
  • AKA SCD2, hSCD2. Soucre: [https://www.uniprot.org/uniprot/Q86SK9].
  • "highly expressed in brain" [PMID:22745828]; "most abundantly expressed in pancreas and brain" [PMID:15610069], "transcripts from adult and foetal tissues exhibit different sizes because of alternative splicing in the non-coding region, suggesting that hSCD2 (aka SCD5, red.) expression is developmentally regulated." [PMID:15610069]
Stearic acidMetaboliteLMFA01010018 (LIPID MAPS)
cis-erucic acidMetabolite112-86-7 (CAS) AKA cis-selacholeic acid
hSCD1ProteinO00767 (Uniprot-TrEMBL)
  • No homologues found for original id L:20250 (Scd2) Human ortholog is SCD, which had mouse orthologs Scd2 and Scd4.
  • "SCD catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA" Source:[https://www.uniprot.org/uniprot/O00767].
  • "predominantly expressed in liver" [PMID:15610069].

Annotated Interactions

SourceTargetTypeDatabase referenceComment
CoA(16:0)CoA(16:1(9Z))Arrow36932 (Rhea)
CoA(18:0)CoA(18:1(9Z))Arrow19722 (Rhea)
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