FGFR3 signaling in chondrocyte proliferation and terminal differentiation (Homo sapiens)

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1Reserve chondrocytesEndochondral ossificationPerichondrium/periosteumproduced by prehypertrophicand hypertrophic chondrocytes AutophagyHypertrophic chondrocytesWntChondrocyte differentiationPre-hypertrophic chondrocytesBMP2ATG5THRAIHHPTHLHMAPK14STAT1NPR2FGF9MAPK12MAPK13CNPMAPK113,3',5'-TriiodothyronineFGFR3FGF18SNAI1PTH1RPTH1RProliferating chondrocytesBMP4OMIM:215045Chondrodysplasia,Blomstrand typeOMIM:600002Eiken syndromeOMIM:156400Metaphyseal chondrodysplasia,Murk Jansen typeOMIM:187600Thanatophoric dysplasia, type IOMIM:187601Thanatophoric dysplasia, type IIOMIM:616482SADDANOMIM:100800AchondroplasiaOMIM:146000HypochondroplasiaOMIM:610474CATSHL syndromeOMIM:613382Brachydactyly, type E2OMIM:612961Multiple synostoses syndrome 3OMIM:607778Acrocapitofemoral dysplasiaOMIM:112600Brachydactyly, type A2OMIM:602875Acromesomelic dysplasia, Maroteaux typeSOX9RBL1CDKN1ARBL1PPPPPPP2CAChondrocyte proliferationOMIM:612247Crouzon syndrome withacanthosis nigricansOMIM:602849Muenke syndromeOMIM:149730LADD syndromeOMIM:215045Chondrodysplasia,Blomstrand typeOMIM:600002Eiken syndromeOMIM:156400Metaphyseal chondrodysplasia,Murk Jansen typeOMIM:615923Epiphyseal chondrodysplasia, Miura typeOMIM:112500Brachydactyly, type A1Syndactyly Lueken type


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Ornitz DM, Legeai-Mallet L; ''Achondroplasia: Development, pathogenesis, and therapy.''; Dev Dyn, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128255view00:10, 30 January 2024EweitzRemove OMIM IDs from shown label, keep in comments as in all other disease nodes
128251view00:06, 30 January 2024EweitzSoften disease color
128250view00:02, 30 January 2024EweitzOntology Term : 'chondrocyte' added !
127270view23:49, 31 August 2023Khanspersfixed phospho sites
116441view09:44, 7 May 2021EweitzModified title
112165view18:32, 29 September 2020Khanspersfixed ptm state comments
110277view07:08, 2 May 2020EgonwNot a mim-conversion
110263view15:32, 30 April 2020EgonwNot a mim-conversion
110236view15:12, 29 April 2020EgonwNot a mim-conversion
109131view06:31, 18 February 2020RleeFixed unconnected line.
108991view00:07, 13 February 2020Khanspersdecreased BoardHeight
108990view00:07, 13 February 2020Khanspersdecreased BoardHeight
108989view00:06, 13 February 2020Khanspersdecreased BoardHeight and BoardWidth
108988view00:05, 13 February 2020Khanspersdecreased BoardHeight
108768view01:56, 29 January 2020RleeRemoved extra DataNode
108767view01:54, 29 January 2020RleeModified description
108766view01:53, 29 January 2020RleeAdded ERK1/2 branch of MAPK pathway
108739view10:56, 27 January 2020DeSlModified description
108738view10:56, 27 January 2020DeSlOntology Term : 'parathyroid hormone signaling pathway' added !
108737view10:55, 27 January 2020DeSlOntology Term : 'thyroid hormone signaling pathway' added !
108736view10:54, 27 January 2020DeSlOntology Term : 'fibroblast growth factor signaling pathway' added !
108735view10:53, 27 January 2020DeSlOntology Term : 'Muenke Syndrome' added !
108734view10:48, 27 January 2020DeSlModified description
108733view10:36, 27 January 2020DeSlModified description
108732view10:33, 27 January 2020DeSlConverted arrows to graphical lines for disease connectivity.
108643view23:09, 14 January 2020RleeFixed unconnected line.
108622view23:44, 12 January 2020RleeModified description
108621view23:40, 12 January 2020RleeModified title
108620view23:40, 12 January 2020RleeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3,3',5'-TriiodothyronineMetaboliteCHEBI:11684 (ChEBI)
ATG5GeneProductENSG00000057663 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CNPGeneProductENSG00000173786 (Ensembl)
FGF18GeneProductENSG00000156427 (Ensembl)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
IHHGeneProductENSG00000163501 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
NPR2GeneProductENSG00000159899 (Ensembl)
PPP2CAGeneProductENSG00000113575 (Ensembl)
PTH1RGeneProductENSG00000160801 (Ensembl)
PTHLHGeneProductENSG00000087494 (Ensembl)
RBL1GeneProductENSG00000080839 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
THRAGeneProductENSG00000126351 (Ensembl)

Annotated Interactions

No annotated interactions

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