Peroxiredoxin 2 induced ovarian failure (Homo sapiens)

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1Ovarian functional degenerationSize of ovaries declineOvarian structural degenerationApoptosisOvarian failureAgingThe number of follicles and Corpora lutea declinesCASP3HSD3B2STARJNKReactive oxygen species Cytochrome CCYP11A1PARP2BAXPeroxiredoxin-2Estradiol-17betaProgesterone


Description

No description

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4835_109250.gpml] with a 62.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134631view11:22, 23 July 2024EweitzOntology Term : 'infertility' added !
134354view05:43, 21 July 2024EgonwRemoved a template comment
110299view15:10, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110067view08:43, 16 April 2020FehrhartOntology Term : 'ovarian dysfunction' added !
110066view08:42, 16 April 2020FehrhartOntology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110065view08:41, 16 April 2020FehrhartModified description
110064view08:39, 16 April 2020FehrhartGraphical adjustments
110063view08:37, 16 April 2020FehrhartAdded reference
109748view15:08, 30 March 2020Bas LahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BAXGeneProductENSG00000087088 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873
CASP3ProteinENSG00000164305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1
CYP11A1ProteinENSG00000140459 (Ensembl)
  • Mitochondrial
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82
Cytochrome CMetaboliteCHEBI:4062 (ChEBI)
  • Somatic
  • Multiple homologues found: En:ENSG00000172115;En:ENSG00000172115;
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
HSD3B2ProteinENSG00000203859 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7
JNKProteinP53779 (Uniprot-TrEMBL)
PARP2GeneProductENSG00000129484 (Ensembl)
Peroxiredoxin-2ProteinP32119 (Uniprot-TrEMBL) No homologues found for original id S:Q61171
ProgesteroneMetaboliteDB00396 (DrugBank)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
STARProteinENSG00000147465 (Ensembl)
  • Mitichondrial
  • Type your comment here
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557

Annotated Interactions

No annotated interactions
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