COVID-19, thrombosis and anticoagulation (Homo sapiens)
From WikiPathways
Description
Several hospitals and researchers have reported links between thrombosis and anticoagulation quite regularly for Covid-19 patients.
This pathways combines this information, including biological mechanisms involved, in one graphical overview.
The graphical visualisation of (crosslinked) fibrin mesh leading to D-dimers is inspired by Wikipedia.Quality Tags
Ontology Terms
Bibliography
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- Kirschbaum NE, Budzynski AZ; ''A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
- Velavan TP, Meyer CG; ''Mild versus severe COVID-19: Laboratory markers.''; Int J Infect Dis, 2020 PubMed Europe PMC Scholia
- Thomas A, Biswas A, Dodt J, Philippou H, Hethershaw E, Ensikat HJ, Ivaskevicius V, Oldenburg J; ''Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.''; Hum Mutat, 2016 PubMed Europe PMC Scholia
- Glenn KC, Frost GH, Bergmann JS, Carney DH; ''Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis.''; Pept Res, 1988 PubMed Europe PMC Scholia
- Muszbek L, Bereczky Z, Bagoly Z, Komáromi I, Katona É; ''Factor XIII: a coagulation factor with multiple plasmatic and cellular functions.''; Physiol Rev, 2011 PubMed Europe PMC Scholia
- Redman CM, Xia H; ''Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC Scholia
- Ichinose A, McMullen BA, Fujikawa K, Davie EW; ''Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments.''; Biochemistry, 1986 PubMed Europe PMC Scholia
- Adam SS, Key NS, Greenberg CS; ''D-dimer antigen: current concepts and future prospects.''; Blood, 2009 PubMed Europe PMC Scholia
- Connors JM, Levy JH; ''COVID-19 and its implications for thrombosis and anticoagulation.''; Blood, 2020 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Blood Clotting Cascade | Pathway | WP272 (WikiPathways) | |
Blood clotting and drug effects | Pathway | WP4580 (WikiPathways) | |
Complement and Coagulation Cascades | Pathway | WP558 (WikiPathways) | |
D-Dimer | Metabolite | ||
FGA (Aα) | Protein | P02671 (Uniprot-TrEMBL) | "fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene" |
FGA (AαE) | Protein | NP_000499.1 (NCBI Protein) | "Alternate splicing of the FGA gene produces a minor expanded isoform of Aα termed AαE which replaces Aα in 1–3% of circulating fibrinogen" |
FGB (Bβ) | Protein | P02675 (Uniprot-TrEMBL) | "the fibrinogen beta chain (also termed the Bβ or β chain) encoded by the FGB gene" |
FGG (γ') | Protein | NP_068656.2 (NCBI Protein) | "alternate splicing of FGG produces a minor isoform of γ termed γ' which replaces γ in 8–10% of circulating fibrinogen" |
FGG (γ) | Protein | P02679 (Uniprot-TrEMBL) | "fibrinogen gamma chain (also termed the γ chain) encoded by the FGG gene" |
Factor XIII A chain | Protein | P00488 (Uniprot-TrEMBL) | Catalytically active |
Factor XIII B chain | Protein | P05160 (Uniprot-TrEMBL) | Not catalytically active, believed to stabilise A chain |
Fibrin | Metabolite | Q27205 (Wikidata) | |
Fibrinogen | Metabolite | Q381899 (Wikidata) | |
Formation of Fibrin Clot (Clotting Cascade) | Pathway | WP1818 (WikiPathways) | |
Plasmin | Protein | P00747 (Uniprot-TrEMBL) | |
Platelet-mediated interactions with vascular and circulating cells | Pathway | WP4462 (WikiPathways) | |
Thrombin | Protein | P00734 (Uniprot-TrEMBL) | |
fibrin degradation products (FDPs) | Metabolite |
Annotated Interactions
No annotated interactions