MAPK pathway in congenital thyroid cancer (Homo sapiens)

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211, 23, 2714c-JUNELK1c-FOSc-MYCCRAFRASGTP1, 4, 5, 9, 10, 13...MEK2SOS2MAPK3ALK tyrosine kinase receptor2, 263, 7, 8, 12, 21GDPMAPK32, 26SHC121BRAFSOS12, 6, 16-18, 26GRB221


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Bibliography

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  1. Bos JL, Rehmann H, Wittinghofer A; ''GEFs and GAPs: critical elements in the control of small G proteins.''; Cell, 2007 PubMed Europe PMC Scholia
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  6. Prior IA, Hancock JF; ''Ras trafficking, localization and compartmentalized signalling.''; Semin Cell Dev Biol, 2012 PubMed Europe PMC Scholia
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  8. Yan J, Roy S, Apolloni A, Lane A, Hancock JF; ''Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  9. Saavedra HI, Knauf JA, Shirokawa JM, Wang J, Ouyang B, Elisei R, Stambrook PJ, Fagin JA; ''The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
  10. Suárez HG, Du Villard JA, Caillou B, Schlumberger M, Tubiana M, Parmentier C, Monier R; ''Detection of activated ras oncogenes in human thyroid carcinomas.''; Oncogene, 1988 PubMed Europe PMC Scholia
  11. Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ; ''Drugging the undruggable RAS: Mission possible?''; Nat Rev Drug Discov, 2014 PubMed Europe PMC Scholia
  12. Esapa CT, Johnson SJ, Kendall-Taylor P, Lennard TW, Harris PE; ''Prevalence of Ras mutations in thyroid neoplasia.''; Clin Endocrinol (Oxf), 1999 PubMed Europe PMC Scholia
  13. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
  14. Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M; ''Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.''; Oncogene, 2006 PubMed Europe PMC Scholia
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  19. Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J; ''Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.''; Cell, 2007 PubMed Europe PMC Scholia
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  21. Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR; ''Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.''; Proc Natl Acad Sci U S A, 1983 PubMed Europe PMC Scholia
  22. Ritt DA, Monson DM, Specht SI, Morrison DK; ''Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  23. Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
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  25. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA; ''High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  26. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE; ''Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations.''; Am J Clin Pathol, 2003 PubMed Europe PMC Scholia
  27. Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK; ''Regulation of Raf-1 by direct feedback phosphorylation.''; Mol Cell, 2005 PubMed Europe PMC Scholia
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  31. Lavoie H, Therrien M; ''Regulation of RAF protein kinases in ERK signalling.''; Nat Rev Mol Cell Biol, 2015 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
134862view20:13, 27 July 2024EweitzUse gene symbols
134861view20:10, 27 July 2024EweitzStandardize metabolite color, refine alignment
134860view20:09, 27 July 2024EweitzEconomize layout
134855view19:56, 27 July 2024EweitzFix truncated text, economize layout
134356view05:45, 21 July 2024EgonwRemoved a template comment
120795view20:56, 8 January 2022AlexanderPicoReverted to version '17:17, 22 December 2021' by AlexanderPico
120794view20:56, 8 January 2022AlexanderPicoReverted to version '22:59, 29 June 2020' by AlexanderPico
120666view00:17, 23 December 2021EweitzOntology Term : 'PW:0000001' removed !
111017view05:59, 30 June 2020FehrhartOntology Term : 'thyroid cancer' added !
111016view05:58, 30 June 2020FehrhartOntology Term : 'thyroid cancer pathway' added !
111015view05:58, 30 June 2020FehrhartOntology Term : 'altered Erk5 MAPK signaling pathway' added !
111014view05:57, 30 June 2020FehrhartOntology Term : 'Pathway Ontology' added !
111007view06:16, 29 June 2020FehrhartModified title
111002view17:42, 26 June 2020Omranhasanrename Nucleus
110897view11:21, 18 June 2020OmranhasanModified description
110880view11:38, 17 June 2020OmranhasanAdd a KSR1 scaffolding protein with references
110838view09:15, 12 June 2020Omranhasanvisualization
110833view22:19, 11 June 2020Omranhasanadding annotation to the pathway components add visualization
110826view11:19, 10 June 2020Omranhasan_ redrawing the (GDP=>GTP) interaction _adding references to the interactions
110778view11:18, 4 June 2020Omranhasanconnecting nodes
110777view09:23, 4 June 2020Omranhasanconnecting tyrosine kinase receptor to the the adopter proteins ( GRB2,SHC1)
110771view20:56, 3 June 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110769view13:16, 3 June 2020Omranhasantest
110680view11:18, 28 May 2020Fehrharttest2
110679view11:15, 28 May 2020Fehrharttest
110678view11:14, 28 May 2020Fehrhartconnected a line for test
110520view06:48, 17 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110505view11:53, 15 May 2020OmranhasanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALK tyrosine kinase receptorProteinQ9UM73 (Uniprot-TrEMBL)
BRAFGeneProductENSG00000157764 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
ELK1GeneProductELK1 (Uniprot-TrEMBL)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GTPMetaboliteCHEBI:15996 (ChEBI)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl)
  • Also known as ERK
  • Type your comment here
MEKMetaboliteCHEBI:28398 (ChEBI)
RAS ProteinP01112 (Uniprot-TrEMBL)
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
c-FOSGeneProductc-FOS (Uniprot-TrEMBL)
c-JUNGeneProductc-JUN (Uniprot-TrEMBL)
c-MYCGeneProductc-MYC (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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