Nephrogenesis (Homo sapiens)

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11. Induction of pretubular aggregateStromal progenitorPretubular aggregateNephron progenitor cellfrom ureteric bud4. Comma Shaped Stage3. Epithelialized Renal Vesicle2. Primed nephron progenitorFOXD1FGF8TCF21JAG1RSPO1BMP7GREB1LWNT4PAX2OSR1ALDH1A2RSPO3SIX2LHX1MEIS1WNT9B FGF20NOTCH2


Description

This pathway describes the gene signalling pathways active in early nephrogenesis in human development.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R; ''Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.''; Development, 2007 PubMed Europe PMC Scholia
  2. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, Cleper R, Landau D, Kovalski Y, Weissman I, Eisenstein I, Soudack M, Wolf HR, Issler N, Lotan D, Anikster Y, Dekel B; ''Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.''; J Am Soc Nephrol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134598view01:11, 23 July 2024EweitzModified description
134597view01:10, 23 July 2024EweitzStandardize case
118777view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118775view15:56, 1 June 2021Fehrhartadded WNT4 interaction with WNT3A
115258view09:18, 8 February 2021FehrhartModified description
115255view09:02, 8 February 2021FehrhartOntology Term : 'kidney disease' added !
115254view09:02, 8 February 2021FehrhartOntology Term : 'Notch signaling pathway' added !
115253view09:01, 8 February 2021FehrhartOntology Term : 'signaling pathway' added !
115249view08:47, 8 February 2021FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALDH1A2GeneProductENSG00000128918 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GREB1LGeneProductENSG00000141449 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
LHX1GeneProductENSG00000274577 (Ensembl)
MEIS1GeneProductENSG00000143995 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT9B GeneProductENSG00000158955 (Ensembl)

Annotated Interactions

No annotated interactions

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