Role of carnosine in muscle contraction (Homo sapiens)
From WikiPathways
Description
Carnosine is known to be an antioxidant, a metal chelator, a Ca(2+) and enzyme regulator. It also functions as an inhibitor of protein glycosylation and protein-protein cross-linking.
Carnosine has also been linked to overcoming muscle fatigue, and can only be transported into a working muscle cell. This pathway shows the main metabolites of carnosine and their relationship with each other.
Quality Tags
Ontology Terms
Bibliography
View all... |
- Boldyrev AA, Severin SE; ''The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance.''; Adv Enzyme Regul, 1990 PubMed Europe PMC Scholia
- Begum G, Cunliffe A, Leveritt M; ''Physiological role of carnosine in contracting muscle.''; Int J Sport Nutr Exerc Metab, 2005 PubMed Europe PMC Scholia
- J.J. O'Dowd, D.J. Robins, D.J. Miller; ''Detection, characterization and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscle''; https://doi.org/10.1016/0304-4165(88)90015-3, 1988 DOI Scholia
- Dobrynina OV, Gorbunova AV; ''[Intensity of biosynthesis of anserine and carnosine by intact and denervated muscles in chickens].''; Biokhimiia, 1968 PubMed Europe PMC Scholia
- JF Lenney; ''Carnosinase and homocarnosinosis''; J. Oslo City Hospitals, 35, pp. 27-40, 1985 PubMed Europe PMC Scholia
- Ferraris RP, Diamond J, Kwan WW; ''Dietary regulation of intestinal transport of the dipeptide carnosine.''; Am J Physiol, 1988 PubMed Europe PMC Scholia
- Nagai K, Suda T; ''Realization of spontaneous healing function by carnosine.''; Methods Find Exp Clin Pharmacol, 1988 PubMed Europe PMC Scholia
- Pegova A, Abe H, Boldyrev A; ''Hydrolysis of carnosine and related compounds by mammalian carnosinases.''; Comp Biochem Physiol B Biochem Mol Biol, 2000 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
AcetylAnserine | Metabolite | Found in Myocardial tissue | |
Acetylcarnosine | Metabolite | Q4673297 (Wikidata) | Found in Myocardial tissue |
Anserine | Metabolite | Q415335 (Wikidata) | |
Carcinine | Metabolite | Q27892933 (Wikidata) | |
Carnosinase | Protein | "present in many tissues (kidney, liver, plasma) with the exceptions of skeletal musculature" | |
Carnosine | Metabolite | Q413822 (Wikidata) | |
Histidine | Metabolite | Q485277 (Wikidata) | |
Homoanserine | Metabolite | 20849429 (PubChem-compound) | |
Homocarnosine | Metabolite | Q27158831 (Wikidata) | |
Ophidine | Metabolite | 90658938 (PubChem-compound) | aka beta-alanyl-3-N-methylhistidine |
beta-alanine | Metabolite | Q310919 (Wikidata) |
|
carnosinase | Protein | 3.4.13.3 (Enzyme Nomenclature) |
|
carnosine synthetase | Protein | 6.3.2.11 (Enzyme Nomenclature) | |
gamma-aminobutyric acid | Metabolite | Q210021 (Wikidata) | |
histamine | Metabolite | Q61233 (Wikidata) |
Annotated Interactions
No annotated interactions