Cell cycle (Bos taurus)

From WikiPathways

Revision as of 11:00, 21 May 2021 by Eweitz (Talk | contribs)
Jump to: navigation, search
1+pe+p+peSS-phase proteins+pDNA damage checkpoint+u+pG1R-point(start)p27,57p21DNA+p+p+p+u+pSecurinp16,15,18,19+uGrowth Factor+p+pSeparin+uDNA+pe+pGrowth Factor withdrawale-p+uMCondensin+p+pe+pG2+p-pCDK2PRKDCApoptosisDBF4CDC25BTBC1D8CCNA2PLK1SKP2TP53EP300YWHAGCDC45LRBL1CCNA1APCAPCE2F6E2F4CHEK2CCNA1E2F3E2F1HDAC7ATRMEN1MAD2L2MDM2PCNARB1CCNB2HDAC2PTTG1CDK1CDC20CCNA2CHEK1UBE2FCDK2SMAD4HDAC4CDKN1BCDK4WEE1CDKN2ACDC14ACCND2BUB3CCNE1HDAC8GSK3BRB1E2F5CDC25ACDC7L1PTTG3CDK6ARF1SMAD3TFDP1TGFB1MAPK Signaling PathwayATMRBL1CCNB3HDAC3SKP2PKMYT1CDK2MCM2CDC14BHDAC6SMC1AUbiquitin-Mediated ProteolysisRB1BUB1BE2F2MPEG1MD2L1CCND3E-CADHERINCDC6KITLGCDK1YWHAGDNA ReplicationPTTG2ABL1GADD45AHDAC1MAD1L1CCNHCDC25CCCNE2HDAC5ESPL1BUB1CCNB1CDKN1AKITLGYWHABYWHAEYWHAHYWHAQYWHAZMCM3MCM4MCM5MCM6MCM7MCM8MCM9MCM10ORC1ORC2ORC3ORC4ORC5LORC6


Description

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


Sources: Wikipedia:Cell cycle, KEGG

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(70629) with a 99.0% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120485view09:24, 8 December 2021EgonwMade four pathways clickable
117485view11:00, 21 May 2021EweitzModified title
115732view09:39, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
89450view12:59, 15 September 2016Mkutmonremove space in ontology term id
80905view15:30, 30 June 2015Mkutmonhomology conversion
71398view19:00, 17 October 2013MaintBotAutomated update of data sources
63321view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62702view23:16, 1 May 2013MaintBotUpdated UniProt data source
40502view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35374view09:16, 12 February 2010MartijnVanIerselModified description
33745view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
32533view13:00, 17 August 2009MaintBotFixed text labels
32220view12:46, 15 August 2009MaintBotFixed text labels
31716view11:53, 14 August 2009MaintBotFixed group labels
31231view19:44, 13 August 2009MaintBotFixed text labels
30652view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl)
  • ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
APCGeneProductENSBTAG00000018852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
ARF1GeneProductENSBTAG00000007725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:375
ATMGeneProductENSBTAG00000003111 (Ensembl)
  • ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:472
ATRGeneProductENSBTAG00000011529 (Ensembl)
  • ATR; ataxia telangiectasia and Rad3 related
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:545
ApoptosisPathwayWP254 (WikiPathways)
BUB1BGeneProductENSBTAG00000007237 (Ensembl)
  • BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:701
BUB1GeneProductENSBTAG00000021181 (Ensembl)
  • BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:699
BUB3GeneProductENSBTAG00000017913 (Ensembl)
  • BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9184
CCNA1GeneProductENSBTAG00000007284 (Ensembl)
  • CCNA1; cyclin A1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8900
CCNA2GeneProductENSBTAG00000004943 (Ensembl)
  • CCNA2; cyclin A2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890
CCNB1GeneProductENSBTAG00000014239 (Ensembl)
  • CCNB1; cyclin B1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891
CCNB2GeneProductENSBTAG00000005269 (Ensembl)
  • CCNB2; cyclin B2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
CCNB3GeneProductENSBTAG00000046286 (Ensembl)
  • CCNB3; cyclin B
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85417
CCND2GeneProductENSBTAG00000016649 (Ensembl)
  • CCND2; cyclin D2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3GeneProductENSBTAG00000010106 (Ensembl)
  • CCND3; cyclin D3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCNE1GeneProductENSBTAG00000004735 (Ensembl)
  • CCNE1; cyclin E
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CCNE2GeneProductENSBTAG00000004906 (Ensembl)
  • CCNE2; cyclin E
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134
CCNHGeneProductENSBTAG00000009566 (Ensembl)
  • CCNH; cyclin H
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902
CDC14AGeneProductENSBTAG00000031439 (Ensembl)
  • CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8556
CDC14BGeneProductENSBTAG00000011589 (Ensembl)
  • CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8555
CDC20GeneProductENSBTAG00000009819 (Ensembl)
  • CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:991
CDC25AGeneProductENSBTAG00000009586 (Ensembl)
  • CDC25A; cell division cycle 25A [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993
CDC25BGeneProductENSBTAG00000008436 (Ensembl)
  • CDC25B; cell division cycle 25B [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDC25CGeneProductENSBTAG00000005293 (Ensembl)
  • CDC25C; cell division cycle 25C [EC:3.1.3.48]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
CDC45LGeneProductENSBTAG00000004286 (Ensembl)
  • CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC6GeneProductENSBTAG00000010384 (Ensembl)
  • CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990
CDC7L1GeneProductENSBTAG00000016307 (Ensembl)
  • CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
CDK1GeneProductENSBTAG00000010109 (Ensembl)
  • CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
CDK2GeneProductENSBTAG00000004021 (Ensembl)
  • CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4GeneProductENSBTAG00000046091 (Ensembl)
  • CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDK6GeneProductENSBTAG00000044023 (Ensembl)
  • CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
CDKN1AGeneProductENSBTAG00000008353 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1BGeneProductENSBTAG00000018254 (Ensembl)
  • CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
CDKN2AGeneProductENSBTAG00000034220 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CHEK1GeneProductENSBTAG00000017582 (Ensembl)
  • CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111
CHEK2GeneProductENSBTAG00000004956 (Ensembl)
  • CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11200
DBF4GeneProductENSBTAG00000014711 (Ensembl)
  • ASK; activator of S phase kinas
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926
DNA ReplicationPathwayWP466 (WikiPathways)
E-CADHERINGeneProductENSBTAG00000015991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
E2F1GeneProductENSBTAG00000003971 (Ensembl)
  • E2F1; E2F transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
E2F2GeneProductENSBTAG00000014400 (Ensembl)
  • E2F2; E2F transcription factor 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870
E2F3GeneProductENSBTAG00000021045 (Ensembl)
  • E2F3; E2F transcription factor 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871
E2F4GeneProductENSBTAG00000012063 (Ensembl)
  • E2F4; E2F transcription factor 4 p107/p130-binding
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1874
E2F5GeneProductENSBTAG00000009378 (Ensembl)
  • E2F5; E2F transcription factor 5 p130-binding
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1875
E2F6GeneProductENSBTAG00000048286 (Ensembl)
  • E2F6; E2F transcription factor 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1876
EP300GeneProductENSBTAG00000016198 (Ensembl)
  • EP300; E1A binding protein p300
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
ESPL1GeneProductENSBTAG00000008934 (Ensembl)
  • ESPL1; extra spindle poles like 1 (S. cerevisiae
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9700
GADD45AGeneProductENSBTAG00000013860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1647
GSK3BGeneProductENSBTAG00000048057 (Ensembl)
  • GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
HDAC1GeneProductENSBTAG00000012698 (Ensembl)
  • HDAC1; histone deacetylase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
HDAC2GeneProductENSBTAG00000011849 (Ensembl)
  • HDAC2; histone deacetylase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3066
HDAC3GeneProductENSBTAG00000017360 (Ensembl)
  • HDAC3; histone deacetylase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8841
HDAC4GeneProductENSBTAG00000017764 (Ensembl)
  • HDAC4; histone deacetylase 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759
HDAC5GeneProductENSBTAG00000016254 (Ensembl)
  • HDAC5; histone deacetylase 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014
HDAC6GeneProductENSBTAG00000013244 (Ensembl)
  • HDAC6; histone deacetylase 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10013
HDAC7GeneProductENSBTAG00000026819 (Ensembl)
  • HDAC7A; histone deacetylase 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564
HDAC8GeneProductENSBTAG00000046092 (Ensembl)
  • HDAC8; histone deacetylase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55869
KITLGGeneProductENSBTAG00000017549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254
MAD1L1GeneProductENSBTAG00000002474 (Ensembl)
  • MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8379
MAD2L2GeneProductENSBTAG00000013275 (Ensembl)
  • MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10459
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MCM10GeneProductENSBTAG00000016406 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388
MCM2GeneProductENSBTAG00000014380 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171
MCM3GeneProductENSBTAG00000010721 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4GeneProductENSBTAG00000017021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM5GeneProductENSBTAG00000015595 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174
MCM6GeneProductENSBTAG00000015172 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7GeneProductENSBTAG00000030965 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
MCM8GeneProductENSBTAG00000014623 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84515
MCM9GeneProductENSBTAG00000002059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:254394
MD2L1GeneProductENSBTAG00000035319 (Ensembl)
  • MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4085
MDM2GeneProductENSBTAG00000010422 (Ensembl)
  • MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
MEN1GeneProductENSBTAG00000002095 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4221
MPEG1GeneProductENSBTAG00000045939 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:219972
ORC1GeneProductENSBTAG00000002719 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
ORC2GeneProductENSBTAG00000031473 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999
ORC3GeneProductENSBTAG00000016969 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595
ORC4GeneProductENSBTAG00000015291 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000
ORC5LGeneProductENSBTAG00000040058 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001
ORC6GeneProductENSBTAG00000001872 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594
PCNAGeneProductENSBTAG00000006065 (Ensembl)
  • PCNA; proliferating cell nuclear antigen
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
PKMYT1GeneProductENSBTAG00000004729 (Ensembl)
  • PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9088
PLK1GeneProductENSBTAG00000014453 (Ensembl)
  • PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5347
PRKDCGeneProductENSBTAG00000017019 (Ensembl)
  • PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
PTTG1GeneProductENSBTAG00000047322 (Ensembl)
  • PTTG1; pituitary tumor-transforming
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9232
PTTG2GeneProductENSBTAG00000047322 (Ensembl)
  • PTTG2; pituitary tumor-transforming
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10744
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProductENSBTAG00000006640 (Ensembl)
  • RB1; retinoblastoma 1 (including osteosarcoma)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
RBL1GeneProductENSBTAG00000011541 (Ensembl)
  • RBL1; retinoblastoma-like 1 (p107)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
SKP2GeneProductENSBTAG00000013562 (Ensembl)
  • SKP2; S-phase kinase-associated protein 2 (p45
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502
SMAD3GeneProductENSBTAG00000012599 (Ensembl)
  • MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
SMAD4GeneProductENSBTAG00000006919 (Ensembl)
  • MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMC1AGeneProductENSBTAG00000017761 (Ensembl)
  • SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
TBC1D8GeneProductENSBTAG00000025898 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11138
TFDP1GeneProductENSBTAG00000019645 (Ensembl)
  • TFDP1; transcription factor Dp-1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
UBE2FGeneProductENSBTAG00000026114 (Ensembl)
  • UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140739
Ubiquitin-Mediated ProteolysisPathwayWP1079 (WikiPathways)
WEE1GeneProductENSBTAG00000005278 (Ensembl)
  • WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465
YWHABGeneProductENSBTAG00000016846 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529
YWHAEGeneProductENSBTAG00000005664 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531
YWHAGGeneProductENSBTAG00000004077 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
YWHAHGeneProductENSBTAG00000011631 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533
YWHAQGeneProductENSBTAG00000002108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZGeneProductENSBTAG00000000236 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1083"
Personal tools