T-cell activation SARS-CoV-2 (Homo sapiens)

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Endoplasmatic ReticulumLysosomeNucleusCytoskeletal ReorganizationAntigen presenting cell (APC)Naive T-cellα2α1β2β1TCRαTCRβCD247CD247CD3εCD3δCD3εCD3γLATB7CD4LCKZAP70CD28PI3KPIP3PDK1AKTmTORC2GSK3TSC2DLGH1p38MAPKN-FATPLC-γ1IP3CaNGRB2SOSRasGRP1RasRafMEK1/2ERKSLP76NCKCDC42PAK1DAGIP3RCa2+Ca2+PRKCQp50RhebmTORC1TSC1N-FATICOSCARD11BCL10MALT1IKKαIKKβNEMOIκBαProliferationCell GrowthGlucose MetabolismProliferationDifferentiationCytokine ProductionInflammationCD45TRIM3FynGADSITKMAP4K1VAV1WASPMEKK1MKK4/7JNKARP2/3p65p50p65c-Junc-Fosc-Junc-Fos


Description

T-cell activation SARS-CoV-2

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Bibliography

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  35. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
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  37. Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R; ''A nucleation barrier spring-loads the CBM signalosome for binary activation.''; Elife, 2022 PubMed Europe PMC Scholia
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  40. Andrew C Chan, Makio Iwashima, christoph W Turck, Arthur Weiss; ''ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain''; Cell, 1992 PubMed Europe PMC Scholia
  41. Huber RG, Fan H, Bond PJ; ''The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain.''; PLoS Comput Biol, 2015 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
135185view03:58, 7 August 2024EweitzClear cache to fix board dimensions
135184view03:57, 7 August 2024EweitzEconomize layout
135183view03:11, 7 August 2024EweitzAnchor interaction
135182view03:10, 7 August 2024EweitzEconomize layout
135181view03:03, 7 August 2024EweitzEconomize layout
135180view02:58, 7 August 2024EweitzTailor node heights
135179view02:38, 7 August 2024EweitzStandardize font name, economize layout
135178view02:32, 7 August 2024EweitzEconomize layout
129246view02:40, 16 March 2024EweitzOntology Term : 'naive T cell' added !
129245view02:39, 16 March 2024EweitzOntology Term : 'professional antigen presenting cell' added !
125315view21:43, 31 January 2023LarsgwAdd PMID to reference
124943view15:41, 3 January 2023EgonwAdded a reference for the CARD11-BLC10-MALT1 complex
124801view21:24, 11 December 2022AlexanderPicoOntology Term : 'T cell' added !
124800view21:24, 11 December 2022AlexanderPicoOntology Term : 'COVID-19' added !
124799view21:22, 11 December 2022AlexanderPicofixed citations
119538view21:24, 13 July 2021Mkutmonfix unconnected line
119489view14:24, 2 July 2021ClclassChanged NFAT2 to NFATC1
119483view08:34, 2 July 2021EgonwNot a mim-conversion and correct ID for Ca2+
119480view11:39, 1 July 2021Clclassenlarged data nodes
119479view10:56, 1 July 2021Clclassenlarged data nodes
119478view10:52, 1 July 2021ClclassEnlarged data nodes, changed gene annotations
119476view20:09, 30 June 2021MkutmonOntology Term : 'T cell' added !
119475view20:09, 30 June 2021MkutmonOntology Term : 'COVID-19' added !
119471view06:27, 30 June 2021EgonwNot mim-conversions
119180view14:10, 20 June 2021ClclassAdded literature annotations
119179view12:58, 20 June 2021Clclassadded transcription targets
119178view10:16, 20 June 2021Clclassadded literatur annotations
119177view10:05, 20 June 2021ClclassAdded CD86
119176view10:04, 20 June 2021ClclassAdded data nodes
119175view08:50, 20 June 2021ClclassAdded annotations
119165view12:39, 19 June 2021ClclassAdded data nodes
119158view12:37, 18 June 2021ClclassAdded transcriptional targets and identifiers
119095view08:35, 17 June 2021FinterlyAdded PubMed IDs
119065view08:59, 14 June 2021ClclassAdded literature annotations
119051view12:24, 12 June 2021ClclassAdded literature reference
119050view11:55, 12 June 2021ClclassAdded data nodes
119049view09:57, 12 June 2021ClclassAdded Uniprot identifiers
119048view09:54, 12 June 2021ClclassAdded Uniprot identifiers
119047view09:19, 12 June 2021ClclassAdded Uniprot identifiers
119046view09:01, 12 June 2021ClclassAdded Uniprot identifiers
119032view10:21, 11 June 2021ClclassDeleted a pathway
119031view10:01, 11 June 2021ClclassAdded new pathways and annotations
118982view13:28, 6 June 2021ClclassAdded Data nodes and Literature references
118643view13:22, 31 May 2021ClclassAdded Literature Annotations
118614view07:15, 31 May 2021ClclassAdded Literature Annotations
118556view11:47, 28 May 2021ClclassAdded Literature Annotations
118123view18:24, 24 May 2021ClclassAdded Literature Annotations
118122view18:11, 24 May 2021ClclassAdded Literature Annotations
117102view11:45, 17 May 2021ClclassAdded literature annotations
116776view09:49, 14 May 2021EweitzModified title

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTProteinP31749 (Uniprot-TrEMBL)
ARP2/3ProteinO15144 (Uniprot-TrEMBL)
B7ProteinQ7Z7D3 (Uniprot-TrEMBL)
BCL10ProteinO95999 (Uniprot-TrEMBL)
CARD11ProteinQ9BXL7 (Uniprot-TrEMBL)
CD247ProteinP20963 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD3γProteinP09693 (Uniprot-TrEMBL)
CD3δProteinP04234 (Uniprot-TrEMBL)
CD3εProteinP07766 (Uniprot-TrEMBL)
CD45ProteinP08575 (Uniprot-TrEMBL)
CD4ProteinP01730 (Uniprot-TrEMBL)
CDC42ProteinQ9NRR8 (Uniprot-TrEMBL)
CaNProteinP48454 (Uniprot-TrEMBL)
DAGMetabolite
DLGH1Protein
ERKProteinQ8TD08 (Uniprot-TrEMBL)
FynProteinP06241 (Uniprot-TrEMBL)
GADSProteinO75791 (Uniprot-TrEMBL)
GRB2ProteinP62993 (Uniprot-TrEMBL)
GSK3ProteinP49841 (Uniprot-TrEMBL)
ICOSProteinQ9Y6W8 (Uniprot-TrEMBL)
IKKαProteinO15111 (Uniprot-TrEMBL)
IKKβProteinO14920 (Uniprot-TrEMBL)
IP3Metabolite
IP3RProteinQ14643 (Uniprot-TrEMBL)
ITKProteinQ08881 (Uniprot-TrEMBL)
IκBαProteinP25963 (Uniprot-TrEMBL)
JNKProteinP45983 (Uniprot-TrEMBL)
LATProteinO43561 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
MALT1ProteinQ9UDY8 (Uniprot-TrEMBL)
MAP4K1ProteinQ92918 (Uniprot-TrEMBL)
MEK1/2ProteinQ02750 (Uniprot-TrEMBL)
MEKK1ProteinQ13233 (Uniprot-TrEMBL)
MKK4/7ProteinP45985 (Uniprot-TrEMBL)
N-FATProteinQ13469 (Uniprot-TrEMBL)
NCKProteinP16333 (Uniprot-TrEMBL)
NEMOProteinQ9Y6K9 (Uniprot-TrEMBL)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PDK1ProteinO15530 (Uniprot-TrEMBL)
PI3KProteinP27986 (Uniprot-TrEMBL)
PIP3Metabolite
PLC-γ1ProteinP19174 (Uniprot-TrEMBL)
PRKCQProteinQ04759 (Uniprot-TrEMBL)
RafProteinP04049 (Uniprot-TrEMBL)
RasGRP1ProteinO95267 (Uniprot-TrEMBL)
RasProteinP01112 (Uniprot-TrEMBL)
RhebProteinQ15382 (Uniprot-TrEMBL)
SLP76ProteinQ13094 (Uniprot-TrEMBL)
SOSProteinQ07889 (Uniprot-TrEMBL)
TCRαProteinQ6ISU1 (Uniprot-TrEMBL)
TCRβProtein
TRIM3ProteinO75382 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
VAV1ProteinP15498 (Uniprot-TrEMBL)
WASPProteinP42768 (Uniprot-TrEMBL)
ZAP70ProteinP43403 (Uniprot-TrEMBL)
c-FosProteinP01100 (Uniprot-TrEMBL)
c-JunProteinP05412 (Uniprot-TrEMBL)
mTORC1ProteinP42345 (Uniprot-TrEMBL)
mTORC2ProteinQ6R327 (Uniprot-TrEMBL)
p38MAPKProteinQ16539 (Uniprot-TrEMBL)
p50ProteinP19838 (Uniprot-TrEMBL)
p65ProteinQ04206 (Uniprot-TrEMBL)
α1ProteinP20036 (Uniprot-TrEMBL)
α2Protein
β1ProteinP04440 (Uniprot-TrEMBL)
β2Protein

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5098"
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