T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection (Homo sapiens)

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1DNASuperantigen (SEB)Proliferation, Differentiation, Immune responseSHP1PIP3DagPLC-1yIKbPKC-thetaRafTNF-alphaIL2Grb2NckNIKCD45RASSLP76CblCOTAktJunCalcineurinGADSIL4IP3Dlgh1TCR-alphaIKK-gammaAP1CalmodulinERKMEK2MEK1IKK-betaCd8LATIL10Malt1Pdk1FynPI3KLckCtla4MKK7CD3p38NF-KbCD40LJNK2ItkIFN-gammaCd4CARMA1PD1IL5Bcl10FosPakGM-CSFTCR-betaGsk3bSOSCd28GRP1CalciumTAK1Cdk4ICOSNFATZap70IKK-alphaGrb2RASCalciumCalmodulin


Description

This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography). The pathway displays the T-cell receptors of homo sapiens when infected with the disease Staphylococcus Enterotoxin B. The binding of a superantigen to the T cell receptor results in a protein signaling pathway resulting in cell proliferation, differentiation, and immune response due to altered DNA expression. SEB refers to Staphylococcal Enterotoxin B.

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Ontology Terms

 

Bibliography

  1. Tomar N, De RK; ''A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway.''; PLoS One, 2013 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127932view23:07, 17 January 2024Khanspersimproved layout
121717view15:08, 26 February 2022EweitzFix IDs, use gene symbols
121707view04:41, 26 February 2022EweitzUse gene symbol
120420view13:10, 30 November 2021EweitzFix incorrectly-cased symbols, and update some others to Ensembl preferred label
116778view09:50, 14 May 2021EweitzModified title
116777view09:49, 14 May 2021EweitzModified title
106753view13:23, 17 September 2019MaintBotHMDB identifier normalization
97627view10:08, 31 May 2018AMTanOntology Term : 'T cell' added !
90702view11:53, 13 December 2016EveloModified title
90701view11:53, 13 December 2016EveloModified title
90029view19:38, 8 October 2016AlexanderPicoModified description
89739view23:37, 29 September 2016KhanspersModified title
89738view23:36, 29 September 2016KhanspersModified description
89737view23:35, 29 September 2016Khansperscorrected label
89641view23:03, 22 September 2016Khanspersminor layout
89607view09:09, 20 September 2016EgonwReverted a premature change I made. Clearly human now.
88763view19:06, 14 August 2016AAR&CoModified description
88762view18:59, 14 August 2016AAR&CoAdded Data Nodes
88759view18:51, 14 August 2016AAR&CoEdited Annotations
88758view18:47, 14 August 2016AAR&CoModified Datanodes
88752view18:38, 14 August 2016AAR&CoPeriodical save, work in progress
88747view18:28, 14 August 2016AAR&CoPeriodical save, work in progress
88742view18:18, 14 August 2016AAR&CoPeriodical save, work in progress
88549view01:34, 11 August 2016AAR&CoPeriodical save, work in progress
88537view00:54, 11 August 2016AAR&CoPeriodical save, work in progress
88533view00:44, 11 August 2016AAR&CoPeriodical save, work in progress
88529view00:24, 11 August 2016AAR&CoPeriodical save, work in progress
88523view00:07, 11 August 2016AAR&CoModified Datanodes
88508view23:18, 10 August 2016AAR&CoPeriodical save, work in progress
88503view23:00, 10 August 2016AAR&CoModified Datanode
88498view22:57, 10 August 2016AAR&CoPeriodical save, work in progress
88496view22:53, 10 August 2016AAR&CoModified Datanodes
88489view22:33, 10 August 2016AAR&CoPeriodical save, work in progress
88483view22:23, 10 August 2016AAR&CoPeriodical save, work in progress
88480view22:12, 10 August 2016AAR&CoPeriodical save, work in progress
88193view23:42, 30 July 2016AAR&CoModified Datanode
88192view23:40, 30 July 2016AAR&CoModified Datanode Gene ID
88189view23:34, 30 July 2016AAR&CoModified Database
88174view14:34, 29 July 2016MkutmonOntology Term : 'infectious disease pathway' added !
88167view08:41, 29 July 2016Mkutmonunconnected lines
87424view11:33, 22 July 2016MkutmonOntology Term : 'immune response pathway' added !
87344view17:39, 21 July 2016AAR&CoModified title
87343view17:39, 21 July 2016AAR&CoAdded Datanodes
87342view17:27, 21 July 2016AAR&CoModified description
87341view17:26, 21 July 2016AAR&CoOntology Term : 'toxic shock syndrome' added !
87340view17:22, 21 July 2016AAR&CoAdded Datanodes
87339view17:21, 21 July 2016AAR&CoPeriodical save, work in progress
87338view17:14, 21 July 2016AAR&CoAdded Data Nodes
87337view17:10, 21 July 2016AAR&CoPeriodical save, work in progress
87336view17:05, 21 July 2016AAR&CoAdded Datanodes

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AP1GeneProductENSG00000177606 (Ensembl)
AktGeneProductENSG00000142208 (Ensembl)
Bcl10GeneProductENSG00000142867 (Ensembl)
CARMA1GeneProductENSG00000198286 (Ensembl)
CD3GeneProductENSG00000167286 (Ensembl) CD3 Not Specified
CD40LGeneProductENSG00000102245 (Ensembl)
CD45GeneProductENSG00000081237 (Ensembl)
COTGeneProductENSG00000107968 (Ensembl)
CalcineurinGeneProductENSG00000187446 (Ensembl)
CalciumMetaboliteHMDB0000464 (HMDB)
CalmodulinProteinENSG00000198668 (Ensembl)
CalmodulinProteinP62204 (Uniprot-TrEMBL)
CblGeneProductENSG00000110395 (Ensembl)
Cd28GeneProductENSG00000178562 (Ensembl)
Cd4GeneProductENSG00000010610 (Ensembl)
Cd8GeneProductENSG00000153563 (Ensembl) CD8 Not Specified
Cdk4GeneProductENSG00000135446 (Ensembl)
Ctla4GeneProductENSG00000163599 (Ensembl)
DagGeneProductQ62165 (Uniprot-TrEMBL) Dag Not Specified
Dlgh1GeneProductENSG00000075711 (Ensembl)
ERKGeneProductENSG00000102882 (Ensembl)
FosGeneProductENSG00000170345 (Ensembl)
FynGeneProductENSG00000010810 (Ensembl)
GADSGeneProductENSG00000100351 (Ensembl)
GM-CSFGeneProductENSG00000164400 (Ensembl)
GRP1GeneProductO08967 (Uniprot-TrEMBL)
Grb2GeneProductENSG00000177885 (Ensembl)
Gsk3bGeneProductENSG00000082701 (Ensembl)
ICOSGeneProductENSG00000163600 (Ensembl)
IFN-gammaGeneProductENSG00000111537 (Ensembl)
IKK-alphaGeneProductENSG00000213341 (Ensembl)
IKK-betaGeneProductENSG00000104365 (Ensembl)
IKK-gammaGeneProductENSG00000269335 (Ensembl)
IKbGeneProductENSG00000100906 (Ensembl) Ikb Not Specified
IL10GeneProductENSG00000136634 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IP3Metabolite439456 (PubChem-compound)
ItkGeneProductENSG00000113263 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
JunGeneProductENSG00000177606 (Ensembl)
LATGeneProductENSG00000213658 (Ensembl)
LckGeneProductENSG00000182866 (Ensembl)
MEK1GeneProductENSG00000169032 (Ensembl)
MEK2GeneProductENSG00000126934 (Ensembl)
MKK7GeneProductENSG00000076984 (Ensembl)
Malt1GeneProductENSG00000172175 (Ensembl)
NF-KbGeneProductENSG00000109320 (Ensembl)
NFATGeneProductENSG00000101096 (Ensembl) General Name for Transcription Factors
NIKGeneProductENSG00000006062 (Ensembl)
NckGeneProductENSG00000158092 (Ensembl)
PD1GeneProductENSG00000188389 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIP3MetaboliteHMDB0010147 (HMDB)
PKC-thetaGeneProductENSG00000065675 (Ensembl)
PLC-1yGeneProductENSG00000124181 (Ensembl)
PakGeneProductENSG00000149269 (Ensembl)
Pdk1GeneProductENSG00000152256 (Ensembl)
RASGeneProductENSG00000126458 (Ensembl)
RafGeneProductENSG00000132155 (Ensembl)
SHP1GeneProductENSG00000111679 (Ensembl)
SLP76GeneProductENSG00000043462 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
TAK1GeneProductENSG00000135341 (Ensembl)
TCR-alphaGeneProductENSG00000211879 (Ensembl)
TCR-betaGeneProductENSG00000281958 (Ensembl)
TNF-alphaGeneProductENSG00000232810 (Ensembl)
Zap70GeneProductENSG00000115085 (Ensembl)
p38GeneProductENSG00000100591 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3863"
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