Glycerolipids and glycerophospholipids (Homo sapiens)

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1, 222232:0 chainAcyl-CoA lengthof side chains:CoALCLCoA(16:0)222222222222GPAM22PPap2aCRLS1CHPT1PAGlycerol-3-P2PCYT22CDS11-acyl-LPA2PISDDGAT1PTDSS2CholineCDP-EtnPNPLA2PLD1DGKZPNPLA3PE2PTDSS1PEMTAGPAT4Acyl-CoA2DAGCDP-DAG22PGPPG2CLPI2PC22Choline-PCDP-CholinePS21-acyl-LPCPE-MePE-Me2CDIPTCHKBPCYT1AEtn-PEtnETNK1GPAT42TAGDGAT222-acyl-PA1-acyl-PEPLA2G1BCoA(16:1)CoA(18:0)CoA(18:1)CoA(20:1)CoA(20:0)CoA(20:4)CoA(16:0)32:1 chainCoA(16:0)34:0 chainCoA(16:0)34:1 chainCoA(16:0)CoA(18:0)36:0 chainCoA(18:0)36:1 chainCoA(18:0)CoA(18:1)CoA(18:0)38:0 chain36:1 chainCoA(18:0)CoA(18:0)38:4 chain2Common pathwayfor TAG andphospholipidsDe novosynthesis ofphospholipidsFatty acidremodelingLPGLPILPCPLA2G1BLPSLPE


Description

This pathway is inspired by the Lipidmaps>Glycerolipids and Glycerophospholipids Pathways expended pathway display [1].

Glycerolipids are composed of mono-, di-, and tri-substituted glycerols, which all function as energy storage.

Glycerophospholipids are also based on glycerol phospholipids, and serve as the main component of biological membranes.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4345_106451.gpml] with a 95.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Yamashita A, Hayashi Y, Matsumoto N, Nemoto-Sasaki Y, Oka S, Tanikawa T, Sugiura T; ''Glycerophosphate/Acylglycerophosphate acyltransferases.''; Biology (Basel), 2014 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
124748view08:51, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
117144view09:41, 18 May 2021EweitzModified title
107599view15:17, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-acyl-LPAMetaboliteLMGP10050000 (LIPID MAPS) aka 1-acyl-sn-glycero-3-phosphate , 1-acylglycerophosphate, lysophosphatic acid
1-acyl-LPCMetaboliteLMGP01050000 (LIPID MAPS)
1-acyl-PEMetaboliteLMGP02050000 (LIPID MAPS)
2-acyl-PAMetaboliteLMGP1005AA00 (LIPID MAPS)
AGPAT4GeneProductENSG00000026652 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68262
Acyl-CoAMetaboliteLMFA07050000 (LIPID MAPS)
CDIPTGeneProductENSG00000103502 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:52858
CDP-CholineMetabolite13804 (PubChem-compound)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-EtnMetabolite123727 (PubChem-compound)
CDS1GeneProductENSG00000163624 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74596
CHKBGeneProductENSG00000100288 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651
CHPT1GeneProductENSG00000111666 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862
CLMetaboliteLMGP12010000 (LIPID MAPS)
CRLS1GeneProductENSG00000088766 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66586
Choline-PMetabolite135437 (PubChem-compound)
CholineMetabolite305 (PubChem-compound)
CoA(16:0)Metabolite1763-10-6 (CAS) AKA "Coenzyme A, S-​hexadecanoate"
CoA(16:1)MetabolitePosition of double bond is unclear.
CoA(18:0)Metabolite362-66-3 (CAS) AKA "Coenzyme A, S-​octadecanoate"
CoA(18:1)Metabolite
CoA(20:0)Metabolite15895-27-9 (CAS) AKA "Coenzyme A, S-​eicosanoate"
CoA(20:1)Metabolite
CoA(20:4)Metabolite
CoAMetaboliteCHEBI:15346 (ChEBI)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DGAT1GeneProductENSG00000185000 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13350
DGAT2GeneProductENSG00000062282 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67800
DGKZGeneProductENSG00000149091 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104418
ETNK1GeneProductENSG00000139163 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320
Etn-PMetabolite1015 (PubChem-compound)
EtnMetabolite700 (PubChem-compound)
GPAMGeneProductENSG00000119927 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14732
GPAT4GeneProductENSG00000158669 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:102247
Glycerol-3-PMetabolite439162 (PubChem-compound)
LCLMetaboliteAKA "Lyso-cardiolipin",(not part of LipidMaps ontology)
LPCMetaboliteLMGP01050000 (LIPID MAPS) AKA "1-acyl-sn-glycero-3-phosphocholine"
LPEMetaboliteLMGP02050000 (LIPID MAPS) AKA "1-acyl-sn-glycero-3-phosphoethanolamine"
LPGMetaboliteAKA "Lysyl-phosphatidylglycerol" (not part of LipidMaps ontology)
LPIMetaboliteAKA "Lysophosphatidylinositol" (not part of LipidMaps ontology)
LPSMetaboliteAKA "1-acyl-sn-glycero-3-phospho-serine",(not part of LipidMaps ontology)
PAMetaboliteLMGP10010000 (LIPID MAPS) aka phosphatidic acid
PCMetaboliteLMGP01010000 (LIPID MAPS)
PCYT1AGeneProductENSG00000161217 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026
PCYT2GeneProductENSG00000185813 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671
PE-Me2MetaboliteLMGP0201AB00 (LIPID MAPS)
PE-MeMetaboliteLMGP0201AA00 (LIPID MAPS)
PEMetaboliteLMGP02010000 (LIPID MAPS)
PEMTGeneProductENSG00000133027 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618
PGMetaboliteLMGP04010000 (LIPID MAPS)
PGPMetaboliteLMGP05010000 (LIPID MAPS)
PIMetaboliteLMGP06010000 (LIPID MAPS)
PISDGeneProductENSG00000241878 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320951
PLA2G1BGeneProductENSG00000170890 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18778
PLD1GeneProductENSG00000075651 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805
PNPLA2GeneProductENSG00000177666 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66853
PNPLA3ProteinENSG00000100344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:116939
PPap2aGeneProductNo homologues found for original id L:19012
PSMetaboliteLMGP03010000 (LIPID MAPS)
PTDSS1GeneProductENSG00000156471 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19210
PTDSS2GeneProductENSG00000174915 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27388
TAGMetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions
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