JAK/STAT pathway (Homo sapiens)

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2cAMPAMPActinCytoskeletonReorganizationApoptosisEnzyme ComplexLegendProtein-Protein InteractionCell CycleRegulation ofCytoskeletonNuCyRegulation ofFood IntakeProtein SynthesisCell GrowthPIAS3KHDRBS1CISHELK1RPS6KA1STAT3GRB2AGAP2SOCS2SOCS3RPS6KB1STAT1STAT1MTORMDM2MAP2K1PTPN1PDE3BPTPN11CISHYWHAZMAP2K2PAK1FYNPIK3R1SIRPAGSK3APRLRFOSRSP6SH2B1IKBKBSHC1MYCIKKNFKB1p7056KEIF4EHRASRAC1PIK3R2ESR1STAT5APXNIRS1GSK3BPP1BIL1RNPRKAA1FLNAEIF4EBP1ZAP70STAT3JAK2PIK3R1BimSTAT1MAPK1IGF2FOXO1BADPI3KPI3KRAF1NEK3SOS1AKT1STAT5BSTAT3JUNCyclinD1IRS1PTPN6NOS3IRS2STAT5ASTAT3CBLMAPK3PRLIKBKGPPIAVAV2CHUKIL1BPTK2NF-kBCCND1CREB1GRB2PPPPPPPPPPPPPGTP1PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPRELARELPp53FOXO3aCREBFKHRCREB1PSTAT1STAT3PPSTAT1STAT3PSTAT5ASTAT5APSTAT5ASTAT5BPSOCS3SOCS2IRF1NFKB1RELARELBAXBCL2L1PRLRGHPGHRGHRPIGF1RLEPRLEPRLEPPLEPERRB2PEGFREGFRPEGFPIK3R2PPIK3CAPIK3CBPPIK3CGIRS2PIRS1PYWHAZSRCPSH2B1BADVAV1PTECITGB1STAT3PESR1ESR1ESR1CISHSTAT3STAT3PPIP3PDK1PIP2DAGPKCCa2+Ca2+ISOC2ISOC1IGF1STAT1STAT1PSTAT1STAT1STAT1PPSTAT1PJAK1STAT3PPRKAA2PPACACAACACBPPCDC42RHOAROCK1ROCK2CFL2PRAC1MAPK8PMAPK14PMAPK8MAPK9PPPRLPP1BPRLPP1BNCOA1SP1TIMP1JAK1STAT1STAT3PIAS3COX2NOS3TWIST1STAT5BSTAT5APAURKAPIAS3mRNAProteinLigandReceptor


Description

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is the central signalling mechanism for many growth factors and cytokines.

JAK activation stimulates cell proliferation, differentiation, cell migration, and apoptosis. These events are critical to immune development, adipogenesis, sexually dimorphic growth, and other processes. Mutations of the JAK/STAT pathway reduces these processes and causes many diseases, including: inflammatory diseases, erythrocytosis, gigantism, and different kinds of leukemia.

Source: PUBMED-ID:15020666

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Quality Tags

Ontology Terms

 

Bibliography

  1. Ali S, Chen Z, Lebrun JJ, Vogel W, Kharitonenkov A, Kelly PA, Ullrich A; ''PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.''; EMBO J, 1996 PubMed Europe PMC Scholia
  2. Rawlings JS, Rosler KM, Harrison DA; ''The JAK/STAT signaling pathway.''; J Cell Sci, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124790view09:02, 11 December 2022EgonwThe identifier was an Entrez Gene identifier
117764view13:26, 22 May 2021EweitzModified title
97833view06:33, 10 June 2018EgonwAdded the reference mentioned in the description.
97832view06:31, 10 June 2018EgonwModified description
97784view14:03, 7 June 2018MaxvansonModified description
97783view14:01, 7 June 2018DeSlReverted to version '13:05, 7 June 2018' by DeSl
97752view13:12, 7 June 2018MaxvansonModified description
97742view13:05, 7 June 2018MaxvansonModified description
96782view16:04, 6 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96770view11:54, 5 April 2018Marvin M2Changed some lines into graphical lines
96769view11:48, 5 April 2018Marvin M2Annotated nodes, updated node types, updated legend into graphical elements
96251view14:25, 2 March 2018Fehrhartconnected some of the unconnected lines
86961view13:28, 15 July 2016MkutmonOntology Term : 'Jak-Stat signaling pathway' added !
74127view05:15, 1 April 2014EgonwFixed the Uniprot-TrEMBL data sources.
72588view04:14, 25 November 2013Prakamya1986New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProduct31 (Entrez Gene)
ACACBGeneProduct32 (Entrez Gene)
AGAP2GeneProductENSG00000135439 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AURKAGeneProduct6790 (Entrez Gene)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BimGeneProduct
CBLGeneProductENSG00000110395 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDC42GeneProduct998 (Entrez Gene)
CFL2GeneProduct1073 (Entrez Gene)
CHUKGeneProductENSG00000213341 (Ensembl)
CISHGeneProduct1154 (Entrez Gene)
CISHGeneProductENSG00000114737 (Ensembl)
COX2GeneProduct4513 (Entrez Gene)
CREBGeneProduct
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CyclinD1GeneProduct
DAGGeneProduct
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
EIF4EGeneProductENSG00000151247 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERRB2GeneProduct
ESR1GeneProduct2099 (Entrez Gene)
FKHRGeneProduct
FLNAGeneProductENSG00000196924 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3aGeneProduct
FYNGeneProductENSG00000010810 (Ensembl)
GHMetaboliteCHEBI:37845 (ChEBI)
GHRGeneProductENSG00000112964 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3AGeneProductENSG00000105723 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HRASGeneProduct3265 (GeneDB)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IGF2GeneProductENSG00000167244 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IKKGeneProduct
IL1BGeneProductENSG00000125538 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IRF1GeneProductENSG00000125347 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
ISOC1GeneProductENSG00000066583 (Ensembl)
ISOC2GeneProductENSG00000063241 (Ensembl)
ITGB1GeneProduct3688 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProductENSG00000177606 (Ensembl)
KHDRBS1GeneProduct10657 (Entrez Gene)
LEPProteinLEP (Uniprot-TrEMBL)
LEPRGeneProductENSG00000116678 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MDM2GeneProductENSG00000135679 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NCOA1GeneProduct8648 (Entrez Gene)
NEK3GeneProduct4752 (Entrez Gene)
NF-kBGeneProduct
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS3GeneProduct4846 (Entrez Gene)
NOS3GeneProductENSG00000164867 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PDE3BGeneProductENSG00000152270 (Ensembl)
PDK1GeneProduct5163 (Entrez Gene)
PI3KGeneProduct
PIAS3GeneProduct10401 (Entrez Gene)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIP2GeneProduct
PIP3GeneProduct
PKCGeneProduct
PP1BGeneProduct
PPIAGeneProduct5478 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRLGeneProduct5617 (Entrez Gene)
PRLRGeneProduct
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN1GeneProductENSG00000196396 (Ensembl)
PTPN6GeneProductENSG00000111679 (Ensembl)
PXNGeneProductENSG00000089159 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene)
RAC1GeneProductENSG00000136238 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RELGeneProduct
RELAGeneProduct
RHOAGeneProduct387 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RSP6GeneProduct
SH2B1GeneProductENSG00000178188 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SIRPAGeneProduct140885 (Entrez Gene)
SOCS2GeneProduct8835 (Entrez Gene)
SOCS2GeneProductENSG00000120833 (Ensembl)
SOCS3GeneProduct9021 (Entrez Gene)
SOCS3GeneProductENSG00000184557 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SP1GeneProduct6667 (Entrez Gene)
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProduct6772 (Entrez Gene)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT1ProteinSTAT1 (Uniprot-TrEMBL)
STAT3GeneProduct6774 (Entrez Gene)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProduct6777 (Entrez Gene)
STAT5BGeneProductENSG00000173757 (Ensembl)
TECGeneProduct7006 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TWIST1GeneProduct7291 (Entrez Gene)
VAV1GeneProductENSG00000141968 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
YWHAZGeneProductENSG00000164924 (Ensembl)
ZAP70GeneProduct7535 (Entrez Gene)
p53GeneProduct
p7056KGeneProduct

Annotated Interactions

No annotated interactions

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