TNF-alpha NF-kB signaling pathway (Mus musculus)

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UbiquitinationGOCY ->NUDesumoylationProteolytic cleavageDPMPalmitoylationNURecruitmentCytoplasmCYMTInhibitionProteins in a complex interactionActivationCY ->NUENLigandControlERReaction through unknown mechanisms/moleculesGolgi apparatusEndosome(Protein-protein interaction)CY ->NUCY ->NUEndoplasmic reticulumMethylationPlasma membraneAutophosphorylationAcetylationEnzyme complexGlycosylationSumoylationMolecular associationDeubiquitinationReceptorPhosphorylationMitochondrionAccession Number: NetPath 9; cellmap:9ECNucleusDeacetylationTranslocationMolecule in the pathwayDemethylationCY ->NUExtracellularDephosphorylationTnfrsf1bTifaTnip2Ube2iMap3k3Rasal2Fkbp5Iqgap2TnfTraf2Gab1Psmc2Cul1Akap8Peg3CyldUsp11Ppp1r13lDpf2TankRnf25Ripk3Psmd7Kpna3Zfand5GeneNlrp4eSmarca4Smarcb1Ddx3xPsmc3RPL6IkbkeTnfrsf8Polr1aCasp8ap2RPL8Pkn1TxlnaGsk3bHdac2RelbRelFlnaRelaMap2k5AlplPsmb5Hdac6RelaPias3Map3k3Smarce1CraddRPL30Polr1dPebp1FaddGm4596Usp2Map3k7ip3Cops3GeneCasp8IkbkgNfkbieNkiras1Tnfaip3UBCH5BBcl3NfkbiaAzi2Gm2423Map3k8Ktn1Map3k14Glg1Nfkb2Trpc4apMap3k7ip1Psmd12Kpna6Nfkb1Pfdn2SrcTraf4Eif4a3Psmd6PmlCasp2Gtf2iRelaChukPsmc1G3bp2Akt1Bag4Casp7Cd3eapHIST3H3Polr2hKPNA2PapolaSKP1APtk2Mark2CSNK2A1Map3k7ip2Polr1cGeneKcnq1DapTraddTnfMcm5Tnfrsf1aSmarcc1IkbkbFblGm10774Nr2c2SUMO1Traf1IkbkgYwhaeBCL7APsmd13Rps6ka5Ripk2Tbk1Commd1Hdac1Tnfrsf1aRPS13Birc3MCCNfkbiaNfkbibNr2c2PrkczGeneTraf2Traf4RelChukBirc2Rps11Traf1Cdc37Actl6aTnip1Ppp2caMtif2TnfRipk1Hsp90ab1Traf6Tnfrsf1bPdcd2TnfNfkb1RelaTraf5Nkiras2YwhabUnc5cl2610301G19RikIkbkapNfkbiaMap3k1Mcm7Birc3Nfkb1Traf2Cdc34TnfCapn3LrpprcCasp3Psmd1Csnk2a2NsmafCASP10TraddNfkbizTbk1Akt2Rnf216Map3k2Birc2Tnfrsf1bTraf3Tnfrsf1aPsmd3YwhazCflarCav1Rpl4TnfFbxw11Ptpn11Faf1TraipFancd2Polr1eCsnk2bBtrcRPS6KB1CrebbpTnfrsf11aPolr1bRipk1Gnb2l1RelbSmarcc2YwhagGene SymbolStat1Hsp90aa1Hspb1PrkacaWdr68Ywhah


Description

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Comments

WikiPathways description 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 91% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118927view14:51, 4 June 2021EgonwModified description
118924view11:15, 4 June 2021Mkutmonupdate description
118923view11:15, 4 June 2021Mkutmonupdate description
116715view09:56, 11 May 2021EweitzModified title
69201view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67701view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41391view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34428view23:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32375view16:51, 15 August 2009MaintBotFixed text labels
32011view13:20, 14 August 2009MaintBotFixed group labels
31412view20:54, 13 August 2009MaintBotFixed text labels
30882view00:17, 30 July 2009MaintBotConverted from Homo sapiens
21197view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP246]]: Moved to stable identifier
8448view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7840view16:22, 18 December 2007MaintBotfixed category names
7308view12:42, 4 November 2007MaintBotAdded categories to GPML
6503view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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Actl6aGeneProduct56456 (Entrez Gene)
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Azi2GeneProduct27215 (Entrez Gene)
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CASP10GeneProduct
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GeneGeneProduct
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HIST3H3GeneProduct
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Hsp90aa1GeneProduct15519 (Entrez Gene)
Hsp90ab1GeneProduct15516 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
IkbkapGeneProduct230233 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
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Iqgap2GeneProduct544963 (Entrez Gene)
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LrpprcGeneProduct72416 (Entrez Gene)
MCCGeneProduct328949 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
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Map3k14GeneProduct53859 (Entrez Gene)
Map3k2GeneProduct26405 (Entrez Gene)
Map3k3GeneProduct26406 (Entrez Gene)
Map3k7ip1GeneProduct66513 (Entrez Gene)
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Nfkb1GeneProduct18033 (Entrez Gene)
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Nkiras1GeneProduct69721 (Entrez Gene)
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Nlrp4eGeneProduct446099 (Entrez Gene)
Nr2c2GeneProduct22026 (Entrez Gene)
NsmafGeneProduct18201 (Entrez Gene)
PapolaGeneProduct18789 (Entrez Gene)
Pdcd2GeneProduct18567 (Entrez Gene)
Pebp1GeneProduct23980 (Entrez Gene)
Peg3GeneProduct18616 (Entrez Gene)
Pfdn2GeneProduct18637 (Entrez Gene)
Pias3GeneProduct229615 (Entrez Gene)
Pkn1GeneProduct320795 (Entrez Gene)
PmlGeneProduct18854 (Entrez Gene)
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Polr1dGeneProduct20018 (Entrez Gene)
Polr1eGeneProduct64424 (Entrez Gene)
Polr2hGeneProduct245841 (Entrez Gene)
Ppp1r13lGeneProduct333654 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
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PrkczGeneProduct18762 (Entrez Gene)
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Ptk2GeneProduct14083 (Entrez Gene)
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RPL30GeneProduct19946 (Entrez Gene)
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RPL8GeneProduct26961 (Entrez Gene)
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RPS6KB1GeneProduct72508 (Entrez Gene)
Rasal2GeneProduct226525 (Entrez Gene)
RelGeneProduct19696 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
RelbGeneProduct19698 (Entrez Gene)
Ripk1GeneProduct19766 (Entrez Gene)
Ripk2GeneProduct192656 (Entrez Gene)
Ripk3GeneProduct56532 (Entrez Gene)
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Rnf25GeneProduct57751 (Entrez Gene)
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SUMO1GeneProduct22218 (Entrez Gene)
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UBCH5BGeneProduct
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YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)
Zfand5GeneProduct22682 (Entrez Gene)

Annotated Interactions

No annotated interactions
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