Leukotriene metabolic pathway (Homo sapiens)

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20-carboxy-LTB45-LOGGT1LTB4LTA4H16-carboxy-LTE420-carboxy-LTE4LTD4LTC4 synthasedeficiencyLTA418-carboxy-LTE4LTC4SArachidonic acidGlutathione5-LO16-carboxy-LTB4LTE4N-acetyl-LTE4(C2)–COOH-LTE(C2)–COOH–LTB20-hydroxy-LTB45-LOAPDPEP1LTC45-Hydroperoxyeicosatetraenoic acid20-OH-LTE418-carboxy-LTB4GlutathionuriaCysteinylglycinasedeficiency


Description

metabolic pathway leuktoriene

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Wheelan P, Hankin JA, Bilir B, Guenette D, Murphy RC; ''Metabolic transformations of leukotriene B4 in primary cultures of human hepatocytes.''; J Pharmacol Exp Ther, 1999 PubMed Europe PMC Scholia
  2. Welsch DJ, Creely DP, Hauser SD, Mathis KJ, Krivi GG, Isakson PC; ''Molecular cloning and expression of human leukotriene-C4 synthase.''; Proc Natl Acad Sci U S A, 1994 PubMed Europe PMC Scholia
  3. Lam BK, Owen WF Jr, Austen KF, Soberman RJ; ''The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils.''; J Biol Chem, 1989 PubMed Europe PMC Scholia
  4. Wickham S, West MB, Cook PF, Hanigan MH; ''Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes.''; Anal Biochem, 2011 PubMed Europe PMC Scholia
  5. Kikuta Y, Kusunose E, Kondo T, Yamamoto S, Kinoshita H, Kusunose M; ''Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.''; FEBS Lett, 1994 PubMed Europe PMC Scholia
  6. De Carolis E, Denis D, Riendeau D; ''Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.''; Eur J Biochem, 1996 PubMed Europe PMC Scholia
  7. Lee CW, Lewis RA, Corey EJ, Austen KF; ''Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.''; Immunology, 1983 PubMed Europe PMC Scholia
  8. Mesa J, Alsina C, Oppermann U, Parés X, Farrés J, Porté S; ''Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.''; Chem Biol Interact, 2015 PubMed Europe PMC Scholia
  9. Petrich K, Ludwig P, Kühn H, Schewe T; ''The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.''; Biochem J, 1996 PubMed Europe PMC Scholia
  10. Ivanov I, Golovanov AB, Ferretti C, Canyelles-Niño M, Heydeck D, Stehling S, Lluch JM, González-Lafont À, Kühn H; ''Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.''; ACS Chem Biol, 2019 PubMed Europe PMC Scholia
  11. Sala A, Voelkel N, Maclouf J, Murphy RC; ''Leukotriene E4 elimination and metabolism in normal human subjects.''; J Biol Chem, 1990 PubMed Europe PMC Scholia
  12. Odlander B, Claesson HE, Bergman T, Rådmark O, Jörnvall H, Haeggström JZ; ''Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.''; Arch Biochem Biophys, 1991 PubMed Europe PMC Scholia
  13. Gupta N, Gresser MJ, Ford-Hutchinson AW; ''Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase.''; Biochim Biophys Acta, 1998 PubMed Europe PMC Scholia
  14. Rudberg PC, Tholander F, Andberg M, Thunnissen MM, Haeggström JZ; ''Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  15. Rouzer CA, Matsumoto T, Samuelsson B; ''Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC Scholia
  16. Adachi H, Kubota I, Okamura N, Iwata H, Tsujimoto M, Nakazato H, Nishihara T, Noguchi T; ''Purification and characterization of human microsomal dipeptidase.''; J Biochem, 1989 PubMed Europe PMC Scholia
  17. Kalsotra A, Turman CM, Kikuta Y, Strobel HW; ''Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.''; Toxicol Appl Pharmacol, 2004 PubMed Europe PMC Scholia
  18. Smyrniotis CJ, Barbour SR, Xia Z, Hixon MS, Holman TR; ''ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.''; Biochemistry, 2014 PubMed Europe PMC Scholia
  19. Kikuta Y, Kusunose E, Sumimoto H, Mizukami Y, Takeshige K, Sakaki T, Yabusaki Y, Kusunose M; ''Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).''; Arch Biochem Biophys, 1998 PubMed Europe PMC Scholia
  20. Horn T, Reddy Kakularam K, Anton M, Richter C, Reddanna P, Kuhn H; ''Functional characterization of genetic enzyme variations in human lipoxygenases.''; Redox Biol, 2013 PubMed Europe PMC Scholia
  21. Kikuta Y, Kusunose E, Kusunose M; ''Characterization of human liver leukotriene B(4) omega-hydroxylase P450 (CYP4F2).''; J Biochem, 2000 PubMed Europe PMC Scholia
  22. Berry KA, Borgeat P, Gosselin J, Flamand L, Murphy RC; ''Urinary metabolites of leukotriene B4 in the human subject.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  23. Raulf M, König W, Köller M, Stüning M; ''Release and functional characterization of the leukotriene D4-metabolizing enzyme (dipeptidase) from human polymorphonuclear leucocytes.''; Scand J Immunol, 1987 PubMed Europe PMC Scholia
  24. Jin R, Koop DR, Raucy JL, Lasker JM; ''Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4.''; Arch Biochem Biophys, 1998 PubMed Europe PMC Scholia
  25. McGee J, Fitzpatrick F; ''Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.''; J Biol Chem, 1985 PubMed Europe PMC Scholia
  26. Kikuta Y, Kato M, Yamashita Y, Miyauchi Y, Tanaka K, Kamada N, Kusunose M; ''Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.''; DNA Cell Biol, 1998 PubMed Europe PMC Scholia
  27. Stec DE, Roman RJ, Flasch A, Rieder MJ; ''Functional polymorphism in human CYP4F2 decreases 20-HETE production.''; Physiol Genomics, 2007 PubMed Europe PMC Scholia
  28. Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN; ''Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.''; Proc Natl Acad Sci U S A, 2016 PubMed Europe PMC Scholia
  29. Sjölinder M, Tornhamre S, Claesson HE, Hydman J, Lindgren J; ''Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.''; J Lipid Res, 1999 PubMed Europe PMC Scholia
  30. Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN; ''The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.''; FASEB J, 2013 PubMed Europe PMC Scholia
  31. Murphy RC, Gijón MA; ''Biosynthesis and metabolism of leukotrienes.''; Biochem J, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
125324view22:15, 31 January 2023LarsgwFix references
122629view10:53, 22 April 2022FehrhartUpdated layout for pathways
122590view10:21, 20 April 2022EweitzModified title
122520view12:55, 13 April 2022DeSlUpdated chapter nr in description
122499view08:17, 13 April 2022DeSlOntology Term : 'brain ischemia' added !
122498view08:16, 13 April 2022DeSlOntology Term : 'cerebrovascular disease' added !
122497view08:13, 13 April 2022DeSlAdded more details to description
122496view07:55, 13 April 2022DeSlUpdated description of PW
122495view07:50, 13 April 2022DeSlUpdated info for DPEP1 disorder; added link to other relevant PW
122494view07:42, 13 April 2022DeSlOntology Term : 'gamma-glutamyl transpeptidase deficiency' added !
122257view13:36, 16 March 2022PeterSwanenbergadded references
122173view21:26, 14 March 2022PeterSwanenbergOntology Term : 'cerebral infarction' added !
122172view21:24, 14 March 2022PeterSwanenbergOntology Term : 'autosomal dominant nonsyndromic deafness' added !
122171view21:18, 14 March 2022PeterSwanenbergtried making the RHEA and reactome IDs functional

some small layout changes

added 2 new diseases
122098view22:39, 10 March 2022DeSlConnected unconnected line
122097view22:27, 10 March 2022DeSlAdded comments on 16-carboxy-LTB4
122096view22:08, 10 March 2022DeSlAdded some more IDs for metabolites
122090view16:34, 10 March 2022DeSlAdded LTE3 metabolite node (no ID found yet)
122089view16:23, 10 March 2022DeSlAdded additonal ref for not annotated metabolites bottom right corner, added two protein annotations
122000view08:34, 9 March 2022PeterSwanenbergOntology Term : 'glutathionuria disease pathway' added !
121999view08:33, 9 March 2022PeterSwanenbergOntology Term : 'leukotriene C4 synthase deficiency pathway' added !
121650view11:17, 23 February 2022PeterSwanenbergLayout changes
121647view11:07, 23 February 2022PeterSwanenbergLayout changes
121642view10:05, 23 February 2022PeterSwanenbergAdded literature and some layout changes
121635view16:24, 22 February 2022PeterSwanenbergChanged one identifier
121599view18:10, 21 February 2022AndraOntology Term : 'leukotriene metabolic pathway' added !
121544view10:13, 21 February 2022PeterSwanenbergModified description
121540view10:10, 21 February 2022PeterSwanenbergAdded Legend
121534view09:07, 21 February 2022PeterSwanenbergForgot an arrow
121533view09:06, 21 February 2022PeterSwanenbergChange layout and addes some Pahtway nodes
121374view19:30, 16 February 2022PeterSwanenbergAdded enzymes and changed the layout
121344view18:15, 15 February 2022PeterSwanenbergCorrected the Rhea pathways

added extra found enzymes

applied OMIM numbers to disease
121188view22:06, 10 February 2022PeterSwanenbergAdded rhea pathways
121129view14:06, 9 February 2022PeterSwanenberg
121120view10:13, 9 February 2022PeterSwanenberg
121119view10:00, 9 February 2022PeterSwanenbergNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(C2)–COOH-LTEMetabolite
(C2)–COOH–LTBMetabolite
16-carboxy-LTB4Metabolite
16-carboxy-LTE4Metabolite
18-carboxy-LTB4Metabolite
18-carboxy-LTE4Metabolite
20-OH-LTE4MetaboliteCHEBI:28700 (ChEBI)
20-carboxy-LTB4MetaboliteCHEBI:27562 (ChEBI)
20-carboxy-LTE4MetaboliteCHEBI:134517 (ChEBI)
20-hydroxy-LTB4MetaboliteCHEBI:15646 (ChEBI)
5-Hydroperoxyeicosatetraenoic acidMetaboliteCHEBI:15632 (ChEBI)
5-LOAPGeneProductENSG00000132965 (Ensembl)
5-LOGeneProductENSG00000012779 (Ensembl)
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
Cysteinylglycinase deficiency
DPEP1GeneProductENSG00000015413 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GlutathioneMetaboliteCHEBI:16856 (ChEBI)
Glutathionuria
LTA4MetaboliteCHEBI:15651 (ChEBI)
LTA4HGeneProductENSG00000111144 (Ensembl)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4 synthase deficiency
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTC4SGeneProductENSG00000213316 (Ensembl)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
N-acetyl-LTE4MetaboliteCHEBI:7210 (ChEBI)

Annotated Interactions

No annotated interactions

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