PtdIns(4,5)P2 in cytokinesis pathway (Homo sapiens)

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295993867431Phosphoinositides metabolism (Homo sapiens)EZRAFAP1PtdIns(3,4,5)P3PCLCDP-DAGMYL2Septin2PtdIns(4,5)P2RhoAECT2RadixinRAB35OCLR1PtdIns(4,5)P2Airway smooth muscle cell contractionAnillinMoesin


Description

This pathway shows how PtdIns(4,5)P2 acts as a central component in the process of bridge stability during the final steps of cytokinesis. Furthermore, PtdIns(4,5)P2 shows bidirectional interactions with many different metabolites such as anillin, ERM-complex. But also Septin2, F-actin and other depicted components visualized in the pathway are required to finalize cytokinesis between two sister cells.

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Ontology Terms

 

Bibliography

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  1. Croisé P, Estay-Ahumada C, Gasman S, Ory S; ''Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.''; Small GTPases, 2014 PubMed Europe PMC Scholia
  2. Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, Formstecher E, Salomon R, Goud B, Echard A; ''Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.''; Nat Cell Biol, 2011 PubMed Europe PMC Scholia
  3. Echard A; ''Phosphoinositides and cytokinesis: the "PIP" of the iceberg.''; Cytoskeleton (Hoboken), 2012 PubMed Europe PMC Scholia
  4. Zhang L, Maddox AS; ''Anillin.''; Curr Biol, 2010 PubMed Europe PMC Scholia
  5. Liu J, Fairn GD, Ceccarelli DF, Sicheri F, Wilde A; ''Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin.''; Curr Biol, 2012 PubMed Europe PMC Scholia
  6. Fehon RG, McClatchey AI, Bretscher A; ''Organizing the cell cortex: the role of ERM proteins.''; Nat Rev Mol Cell Biol, 2010 PubMed Europe PMC Scholia
  7. Vicinanza M, Di Campli A, Polishchuk E, Santoro M, Di Tullio G, Godi A, Levtchenko E, De Leo MG, Polishchuk R, Sandoval L, Marzolo MP, De Matteis MA; ''OCRL controls trafficking through early endosomes via PtdIns4,5P₂-dependent regulation of endosomal actin.''; EMBO J, 2011 PubMed Europe PMC Scholia
  8. Stith BJ; ''Phospholipase C and D regulation of Src,calcium release and membrane fusion during Xenopus laevis development.''; Dev Biol, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
125330view22:24, 31 January 2023LarsgwFix references
123486view15:21, 28 July 2022DeSlAnnotated last missing datanode
123485view15:19, 28 July 2022DeSlCondensed and straightend out layout of PW, connected unconnected line.
122599view12:44, 20 April 2022EweitzModified description
122288view14:17, 17 March 2022SElBoudllali
122285view14:09, 17 March 2022SElBoudllali
122281view13:43, 17 March 2022SElBoudllalichanged references
122264view16:27, 16 March 2022DeSlOntology Term : 'cell cycle pathway' added !
122263view16:25, 16 March 2022DeSlOntology Term : 'lipid signaling pathway' added !
122260view16:09, 16 March 2022DeSlOntology Term : 'phosphatidylinositol metabolic pathway' added !
122129view14:51, 11 March 2022SElBoudllalichanged references
122128view14:30, 11 March 2022SElBoudllalichanged reference 1
122127view14:26, 11 March 2022SElBoudllalicoverted ECT2 into its subunits
122125view14:18, 11 March 2022SElBoudllaliadded reviewed portein identifiers
122123view12:10, 11 March 2022SElBoudllali
122122view12:08, 11 March 2022SElBoudllali
122118view10:43, 11 March 2022SElBoudllali
122117view10:23, 11 March 2022SElBoudllaliOntology Term : 'signaling pathway' added !
122116view10:22, 11 March 2022SElBoudllaliModified description
122115view10:13, 11 March 2022SElBoudllali
122107view00:03, 11 March 2022DeSlStarting to fix layout
122012view09:45, 9 March 2022SElBoudllali
122002view09:13, 9 March 2022SElBoudllali
121586view16:20, 21 February 2022SElBoudllali
121585view16:19, 21 February 2022SElBoudllali
121584view16:13, 21 February 2022SElBoudllali
121582view15:25, 21 February 2022SElBoudllali
121579view14:59, 21 February 2022SElBoudllali
121578view14:46, 21 February 2022SElBoudllali
121577view14:31, 21 February 2022SElBoudllali
121570view14:11, 21 February 2022SElBoudllali
121567view13:47, 21 February 2022SElBoudllali
121566view13:34, 21 February 2022SElBoudllali
121564view13:20, 21 February 2022SElBoudllaliModified title
121563view13:08, 21 February 2022SElBoudllali
121562view13:06, 21 February 2022SElBoudllali
121561view12:50, 21 February 2022SElBoudllaliNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AFAP1ProteinQ8N556 (Uniprot-SwissProt) In the paper's figure they mention it as f-actin
Airway smooth muscle cell contractionPathwayWP4962 (WikiPathways)
AnillinProteinA0A024RA49 (Uniprot-TrEMBL)
CDP-DAGMetaboliteCHEBI:17962 (ChEBI)
ECT2ProteinC9J0L6 (Uniprot-TrEMBL) is actually a complex, could not find the components
EZR ProteinP15311 (Uniprot-TrEMBL)
MYL2ProteinP10916 (Uniprot-SwissProt)
MoesinProteinP26038 (Uniprot-TrEMBL)
OCLR1GeneProduct
PCLMetaboliteCHEBI:53200 (ChEBI)
Phosphoinositides metabolism (Homo sapiens)PathwayWP4971 (WikiPathways)
PtdIns(3,4,5)P3MetaboliteCHEBI:83416 (ChEBI)
PtdIns(4,5)P2MetaboliteCHEBI:83419 (ChEBI)
RAB35ProteinF5H157 (Uniprot-TrEMBL)
RadixinProteinA0A2R8Y4H6 (Uniprot-TrEMBL)
RhoAGeneProductENSG00000067560 (Ensembl)
Septin2ProteinA0A1B0GXJ2 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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