Synthesis of ceramides and 1-deoxyceramides (Homo sapiens)
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Description
Synthesis of ceramides and 1-deoxyceramides from serine and alanine, respectively, including the synthesis of complex glycosphingolipids in humans. Multiple more complex sphingolipid synthesis reactions were added to improve pathway versatility. 1-deoxyceramide synthesis shows a lot of similarities with ceramide synthesis but does not come close in terms of documentation, hence this comprehensive figure.
Quality Tags
Ontology Terms
Bibliography
- Shayman JA; ''''; , PubMed Europe PMC Scholia
- Chatterjee S, Balram A, Li W; ''Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
- Sen P, Hyötyläinen T, Orešič M; ''1-Deoxyceramides - Key players in lipotoxicity and progression to type 2 diabetes?''; Acta Physiol (Oxf), 2021 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1-Deoxy-3-ketosphinganine | Metabolite | CHEBI:17862 (ChEBI) | |
1-Deoxyceramide | Metabolite | CHEBI:52639 (ChEBI) | |
1-Deoxydihydroceramide | Metabolite | HMDB0006752 (HMDB) | |
1-Deoxysphingosine | Metabolite | HMDB0000252 (HMDB) | |
1-O-acyl-ceramide | Metabolite | CHEBI:133444 (ChEBI) | |
1-deoxysphinganine | Metabolite | CHEBI:67109 (ChEBI) | |
3-ketosphinganine | Metabolite | CHEBI:17862 (ChEBI) | |
A3GALT2 | GeneProduct | ENSG00000184389 (Ensembl) | |
A4GALT | GeneProduct | ENSG00000128274 (Ensembl) | |
ASAH1 | GeneProduct | ENSG00000104763 (Ensembl) | |
B3GNT5 | GeneProduct | ENSG00000176597 (Ensembl) | |
B4GALNT1 | GeneProduct | ENSG00000135454 (Ensembl) | |
B4GALT1 | GeneProduct | ENSG00000086062 (Ensembl) | |
CERK | GeneProduct | ENSG00000100422 (Ensembl) | |
CERS1 | GeneProduct | ENSG00000223802 (Ensembl) | |
CERS2 | GeneProduct | ENSG00000143418 (Ensembl) | |
CERS3 | GeneProduct | ENSG00000154227 (Ensembl) | |
CERS4 | GeneProduct | ENSG00000090661 (Ensembl) | |
CERS5 | GeneProduct | ENSG00000139624 (Ensembl) | |
CERS6 | GeneProduct | ENSG00000172292 (Ensembl) | |
CerP(d18:1/16:0) | Metabolite | CHEBI:72963 (ChEBI) | |
DES | GeneProduct | ENSG00000175084 (Ensembl) | |
DGAT1 | GeneProduct | ENSG00000185000 (Ensembl) | Uncertain, source material did not specify what protein isoform is responsible for this reaction. |
Dihydroceramide | Metabolite | HMDB0006752 (HMDB) | |
GA2 | Metabolite | CHEBI:36774 (ChEBI) | |
Galactosylceramide | Metabolite | CHEBI:18390 (ChEBI) | |
Glucosylceramide | Metabolite | CHEBI:18368 (ChEBI) | |
Hexadecenal | Metabolite | HMDB0060482 (HMDB) | |
KDSR | GeneProduct | ENSG00000119537 (Ensembl) | |
Lc3Cer | Metabolite | HMDB0062485 (HMDB) | |
Palmitoyl-CoA | Metabolite | CHEBI:15525 (ChEBI) | |
Phosphoethanolamine | Metabolite | CHEBI:17553 (ChEBI) | |
S1P lyase | GeneProduct | ||
S1P | Metabolite | CHEBI:37550 (ChEBI) | |
SGMS1 | GeneProduct | ENSG00000198964 (Ensembl) | |
SGMS2 | GeneProduct | ENSG00000164023 (Ensembl) | |
SPHK1 | GeneProduct | ENSG00000176170 (Ensembl) | |
SPTLC1 | Protein | O15269 (Uniprot-TrEMBL) | |
Sphinganine | Metabolite | HMDB0000269 (HMDB) | |
Sphingosine | Metabolite | HMDB0000252 (HMDB) | |
UGCG | GeneProduct | ENSG00000148154 (Ensembl) | |
UGT8 | GeneProduct | ENSG00000174607 (Ensembl) | |
alanine | Metabolite | CHEBI:16449 (ChEBI) | |
ceramide | Metabolite | CHEBI:52639 (ChEBI) | |
ganglioside GM4 | Metabolite | CHEBI:27499 (ChEBI) | |
globoside Gb3Cer | Metabolite | CHEBI:88154 (ChEBI) | |
isogloboside iGb3Cer | Metabolite | CHEBI:140817 (ChEBI) | |
lactosylceramide | Metabolite | CHEBI:134507 (ChEBI) | |
serine | Metabolite | CHEBI:17822 (ChEBI) | |
sphingomyelins | Metabolite | CHEBI:62490 (ChEBI) | |
sphingosine-1-phosphate | Metabolite | CHEBI:37550 (ChEBI) | |
sulphatide | Metabolite | CHEBI:18318 (ChEBI) |
Annotated Interactions
No annotated interactions