Arsenic metabolism and reactive oxygen species generation (Homo sapiens)

From WikiPathways

Revision as of 18:03, 3 August 2022 by Egonw (Talk | contribs)
Jump to: navigation, search
arsenicSOD2MMA (V)COA3ATP1A1O2·–Activation of oncogenic pathwaysSOD1H2O2MT-ND1GSTO1arsenic(5+)SAHH2OVDAC1DMA (V)CATGSSGSDHAarsenic(3+)DMA (III)Mitochondrial dysfunctionGSHS-adenosylmethionineOXPHOSUQCRFS1AS3MTROSMMA (III)GSSGGSHAS3MTS-adenosylmethionineSAHGSHGSSGO2·–H2O2


Description

Arsenic induced ROS formation may lead to carcinogenic effects.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M; ''Arsenic: toxicity, oxidative stress and human disease.''; J Appl Toxicol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135216view11:01, 8 August 2024EgonwAdded a reference
134516view12:35, 22 July 2024EweitzStandardize metabolite color, case
134515view12:27, 22 July 2024EweitzFix interaction connection, economize layout
134114view11:13, 21 June 2024EgonwTranslocation
129331view09:06, 27 March 2024MkutmonOntology Term : 'classic metabolic pathway' added !
123583view12:53, 4 August 2022FehrhartOntology Term : 'cancer' added !
123560view18:03, 3 August 2022EgonwTyped a datanode
122729view13:19, 6 May 2022ZDLechAdded references and fixed interactions.
122714view14:14, 4 May 2022ZDLechChange of shape type for node: Activation of oncogenic pathways
122713view14:10, 4 May 2022ZDLechNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AS3MTGeneProductENSG00000214435 (Ensembl)
ATP1A1GeneProductENSG00000163399 (Ensembl)
Activation of oncogenic pathways
CATGeneProductENSG00000121691 (Ensembl)
COA3GeneProductENSG00000183978 (Ensembl)
DMA (III)Metabolite161508 (Chemspider)
DMA (V)Metabolite2418 (Chemspider)
GSHMetaboliteCHEBI:16856 (ChEBI)
GSSGMetaboliteCHEBI:17858 (ChEBI)
GSTO1GeneProductENSG00000148834 (Ensembl)
H2O2Metabolite16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
MMA (III)Metabolite141846 (Chemspider)
MMA (V)Metabolite8604 (Chemspider)
MT-ND1GeneProductENSG00000198888 (Ensembl)
Mitochondrial dysfunction
O2·–Metabolite18421 (ChEBI)
OXPHOSPathwayWP111 (WikiPathways)
ROS26523 (ChEBI)
S-adenosylmethionineMetaboliteCHEBI:15414 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SDHAGeneProductENSG00000073578 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
UQCRFS1GeneProductENSG00000169021 (Ensembl)
VDAC1GeneProductENSG00000213585 (Ensembl)
arsenic(3+)MetaboliteCHEBI:35828 (ChEBI)
arsenic(5+)MetaboliteCHEBI:35829 (ChEBI)
arsenicMetaboliteCHEBI:27563 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5233"
Personal tools