Mevalonate arm of cholesterol biosynthesis pathway (Homo sapiens)
From WikiPathways
Description
The mevalonate arm of the cholesterol biosynthesis pathway within different cellular regions.
View more details on which drugs are related to these reactions at WP4189. View the broader scope of cholesterol metabolism at WP430.
Quality Tags
Ontology Terms
Pathway Ontology : cholesterol biosynthetic pathway cholesterol biosynthetic pathway mitochondria transport pathway altered cholesterol biosynthetic pathway isoprenoid biosynthetic pathway
Cell Type : cell metabolising cell
Bibliography
- Haines BE, Wiest O, Stauffacher CV; ''The increasingly complex mechanism of HMG-CoA reductase.''; Acc Chem Res, 2013 PubMed Europe PMC Scholia
- Benson HE, Watterson S, Sharman JL, Mpamhanga CP, Parton A, Southan C, Harmar AJ, Ghazal P; ''Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway.''; Br J Pharmacol, 2017 PubMed Europe PMC Scholia
- Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P; ''A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.''; Biochem Pharmacol, 2013 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA | Metabolite | CHEBI:43074 (ChEBI) | |
ACAT1 | Protein | P24752 (Uniprot-TrEMBL) | |
ACAT2 | Protein | Q9BWD1 (Uniprot-TrEMBL) | |
Acetyl-CoA | Metabolite | 57288 (ChEBI) | |
Acetyl-CoA | Metabolite | CHEBI:57288 (ChEBI) | |
FDFT1 | Protein | P37268 (Uniprot-TrEMBL) | |
FDPS | Protein | P14324 (Uniprot-TrEMBL) | |
GGPS1 | Protein | O95749 (Uniprot-TrEMBL) | |
H+ | Metabolite | 15378 (ChEBI) | |
HMGCL | Protein | P35914 (Uniprot-TrEMBL) | |
HMGCR | Protein | P04035 (Uniprot-TrEMBL) | Note: 1.1.1.88 is EC class relevant for bacteria, with corresponding Rhea:14833. This Protein has been annotated with the mammalian EC class 1.1.1.34, corresponding Rhea:15989. |
HMGCS1 | Protein | Q01581 (Uniprot-TrEMBL) | |
HS-CoA | Metabolite | 57287 (ChEBI) | |
IDI1 | Protein | Q13907 (Uniprot-TrEMBL) | TESTCASE: Protein 1 of two individual proteins carrying out the same conversion; same Rhea, diff. kinetic values. |
IDI2 | Protein | Q9BXS1 (Uniprot-TrEMBL) | TESTCASE: Protein 2 of two individual proteins carrying out the same conversion; same Rhea, diff. kinetic values. |
MVD | Protein | P53602 (Uniprot-TrEMBL) | EC 4.1.1.33 |
MVK | Protein | Q03426 (Uniprot-TrEMBL) | |
Mitochondrial
beta-oxidation of fatty acids | Pathway | WP5241 (WikiPathways) | |
NAD(P)+ | Metabolite | CHEBI:18009 (ChEBI) | |
NAD(P)+ | Metabolite | CHEBI:58349 (ChEBI) | |
NAD(P)H | Metabolite | CHEBI:16474 (ChEBI) | |
NAD(P)H | Metabolite | CHEBI:57783 (ChEBI) | |
NAD+ | Metabolite | 57540 (ChEBI) | |
NADH | Metabolite | 57945 (ChEBI) | |
PMVK | Protein | Q15126 (Uniprot-TrEMBL) | |
acetoacetate | Metabolite | 13705 (ChEBI) | |
acetoacetyl-CoA | Metabolite | 57286 (ChEBI) | |
acetoacetyl-CoA | Metabolite | Q2639429 (Wikidata) | TESTCASE: Annotated with ID missing charge; according to Rhea should be CHEBI:57286 |
cholesterol synthesis | Pathway | WP197 (WikiPathways) | |
dimethylallyl-PP | Metabolite | 57623 (ChEBI) | AKA Dimethylallyl diphosphate |
famesyl-PP | Metabolite | 175763 (ChEBI) | |
geranyl-PP | Metabolite | 58057 (ChEBI) | |
geranylgeranyl-PP | Metabolite | 58756 (ChEBI) | |
isopenthyl-PP | Metabolite | 128769 (ChEBI) | |
mevaldyl-CoA | Metabolite | RGCJQGNQJYHPPZ-FMMSQWOCSA-I (InChIKey) |
|
mevaldyl | Metabolite | CWCYSIIDJAVQSK-ZCFIWIBFSA-M (InChIKey) |
|
mevalonate-P | Metabolite | 58146 (ChEBI) | AKA (R)-5-phosphomevalonate |
mevalonate-PP | Metabolite | CHEBI:57557 (ChEBI) | AKA (R)-5-diphosphomevalonate |
mevalonate | Metabolite | CHEBI:36464 (ChEBI) | Annotated with (R)-mevalonate ID |
presqualene-PP | Metabolite | 57310 (ChEBI) | |
protein prenylation | Pathway | ||
squalene | Metabolite | Q407560 (Wikidata) | TESTCASE: correct mapping from Wikidata to ChEBI-ID (based on Rhea) |
Annotated Interactions
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Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
3-hydroxy-3-methylglutaryl-CoA | Acetyl-CoA | mim-conversion | 24405 (Rhea) | |
3-hydroxy-3-methylglutaryl-CoA | mevalonate | mim-conversion | 15991 (Rhea) | |
Acetyl-CoA | 3-hydroxy-3-methylglutaryl-CoA | mim-conversion | 10190 (Rhea) | TESTCASE: Annotated with Rhea ID in opposite direction; should be RHEA:10189 |
Acetyl-CoA | acetoacetyl-CoA | mim-conversion | 21037 (Rhea) | TESTCASE: side metabolite not connected to conversion interaction (compared to ACAT1 interaction) |
Acetyl-CoA | mim-conversion | 10189 (Rhea) | ||
HS-CoA | mim-conversion | 21037 (Rhea) | ||
NAD(P)+ | mim-conversion | 22233 (Rhea) | ||
NAD(P)H | mim-conversion | 22233 (Rhea) | ||
acetoacetate | mim-conversion | 24405 (Rhea) | ||
acetoacetyl-CoA | 3-hydroxy-3-methylglutaryl-CoA | mim-conversion | 10189 (Rhea) | |
dimethylallyl-PP | geranyl-PP | mim-conversion | 22409 (Rhea) | TESTCASE: Substrate 2 out of two, which is needed for conversion, directly connected to product. |
famesyl-PP | geranylgeranyl-PP | mim-conversion | 17654 (Rhea) | |
famesyl-PP | presqualene-PP | mim-conversion | 22673 (Rhea) | |
geranyl-PP | famesyl-PP | mim-conversion | 19362 (Rhea) | TESTCASE: Substrate 1 out of two, which is needed for conversion, connected directly to product, includes anchor to connect substrate 2-> product. |
isopenthyl-PP | dimethylallyl-PP | mim-conversion | 23285 (Rhea) | |
isopenthyl-PP | geranyl-PP | mim-conversion | 22409 (Rhea) | TESTCASE: Substrate 1 out of two, which is needed for conversion, directly connected to product. |
isopenthyl-PP | mim-conversion | 17654 (Rhea) | ||
isopenthyl-PP | mim-conversion | 19362 (Rhea) | TESTCASE: Substrate 2 out of two, which is needed for conversion, connected to product via anchor from substrate 1-> product. | |
mevalonate-PP | isopenthyl-PP | mim-conversion | 23733 (Rhea) | |
mevalonate-P | mevalonate-PP | mim-conversion | 16342 (Rhea) | |
mevalonate | mevalonate-P | mim-conversion | 17066 (Rhea) | |
presqualene-PP | squalene | mim-conversion | 22233 (Rhea) |