Immune infiltration in pancreatic cancer (Homo sapiens)

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34PDACM1 macrophageTh17CD8+ T cellTregMDSCCAFVasculatureTh1NeutrophilTGFB2IL25IL17FIL17BVEGFBTGFB3VEGFCVEGFDIL1BIL17CIL17DIL23AMMP91IL12BIL12BNOIL12ACOIL17AIL10TNFCXCL1IL5IL6IL2IL13CXCL8TGFB1IL13CSF2CXCL8VEGFAIL4IFNGM2 macrophageTh2TNFM2 macrophageIL4IL6IL10NOTGFB3TGFB2TGFB1TGFB3TGFB2TGFB1VEGFCVEGFDVEGFBVEGFAIFNG2IL4IL13IFNGCSF2


Description

Immune cell infiltration in pancreatic cancer. Various factors are secreted in the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) that can either stimulate or inhibit PDAC development. Alteration of PDAC development by immune cells can be direct and/or indirect. The pathway model is based on a review by Liu et al, 2019 (https://doi.org/10.1186/s12943-019-1117-9).

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Ontology Terms

 

Bibliography

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  1. Zhang R, Liu Q, Peng J, Wang M, Li T, Liu J, Cui M, Zhang X, Gao X, Liao Q, Zhao Y; ''CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration.''; J Cancer, 2020 PubMed Europe PMC Scholia
  2. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM; ''T cells in pancreatic cancer stroma.''; World J Gastroenterol, 2021 PubMed Europe PMC Scholia
  3. Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Zhao Y, Tang M; ''The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway.''; Oncol Rep, 2016 PubMed Europe PMC Scholia
  4. Masucci MT, Minopoli M, Carriero MV; ''Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy.''; Front Oncol, 2019 PubMed Europe PMC Scholia
  5. ''''; , PubMed Europe PMC Scholia
  6. Fan JQ, Wang MF, Chen HL, Shang D, Das JK, Song J; ''Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma.''; Mol Cancer, 2020 PubMed Europe PMC Scholia
  7. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, Hua J, Yu X, Shi S; ''The reciprocal regulation between host tissue and immunecells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.''; Mol Cancer, 2019 PubMed Europe PMC Scholia
  8. Ren B, Cui M, Yang G, Wang H, Feng M, You L, Zhao Y; ''Tumor microenvironment participates in metastasis of pancreatic cancer.''; Mol Cancer, 2018 PubMed Europe PMC Scholia
  9. Cui R, Yue W, Lattime EC, Stein MN, Xu Q, Tan XL; ''Targeting tumor-associated macrophages to combat pancreatic cancer.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  10. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M; ''Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies.''; Cancer Treat Rev, 2014 PubMed Europe PMC Scholia
  11. Liu B, Jia Y, Ma J, Wu S, Jiang H, Cao Y, Sun X, Yin X, Yan S, Shang M, Mao A; ''Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer.''; Acta Biochim Biophys Sin (Shanghai), 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128268view00:27, 30 January 2024EweitzOntology Term : 'pancreatic stellate cell' added !
128267view00:26, 30 January 2024EweitzOntology Term : 'fibroblast' added !
128266view00:26, 30 January 2024EweitzOntology Term : 'myeloid suppressor cell' added !
128265view00:25, 30 January 2024EweitzOntology Term : 'T-helper 2 cell' added !
128264view00:25, 30 January 2024EweitzOntology Term : 'T-helper 1 cell' added !
128263view00:25, 30 January 2024EweitzOntology Term : 'T-helper 17 cell' added !
128262view00:24, 30 January 2024EweitzOntology Term : 'neutrophil' added !
128261view00:24, 30 January 2024EweitzOntology Term : 'regulatory T cell' added !
128260view00:24, 30 January 2024EweitzOntology Term : 'macrophage' added !
125922view11:07, 20 March 2023IsabelWassinkOntology Term : 'disease pathway' added !
125921view09:24, 20 March 2023IsabelWassinkminor changes in layout
125902view13:07, 17 March 2023IsabelWassinkminor layout changes
125081view12:47, 20 January 2023IsabelWassinkOntology Term : 'immune response pathway' added !
124818view08:36, 12 December 2022IsabelWassinkremoved vasculature data node
124598view13:54, 14 November 2022IsabelWassinkModified description
124557view14:28, 8 November 2022DdiglesCXCL5 identifier reload (is causing test failures)
124469view09:10, 30 October 2022DdiglesRemoved "(Ensembl)" in identifier of CCL5
124457view14:51, 28 October 2022IsabelWassinkUpdated pathway
124383view13:07, 21 October 2022IsabelWassinkREG4 data node added
124344view11:38, 18 October 2022IsabelWassinkPathway extended
124341view14:10, 17 October 2022IsabelWassinkModified description
124320view12:19, 13 October 2022IsabelWassinkPathway extended with new data node with reference
124300view13:48, 11 October 2022IsabelWassinkUpdated the layout
124298view11:55, 11 October 2022IsabelWassinkInteraction between macrophages and MDSC added
124282view09:40, 7 October 2022IsabelWassinkNew interaction with reference between Th1 and CD8+ T cell
124281view08:19, 7 October 2022IsabelWassinkMMP9 data node and reference added
124262view10:05, 6 October 2022IsabelWassinkNames changed to official gene names and arrows to show secretion changed
124240view14:41, 4 October 2022IsabelWassinkUpdated the TNFA identifier
124215view12:20, 30 September 2022IsabelWassinkData nodes added
124211view14:35, 29 September 2022IsabelWassinkShape of metabolite data nodes changed to rounded rectangles
124210view13:39, 29 September 2022IsabelWassinkUpdated secreted factors to groups instead of individual nodes and linked the groups to cells in the pathway
124201view14:49, 27 September 2022IsabelWassinkModified description
124199view11:57, 27 September 2022IsabelWassinkPDAC cell color changed for clarity
124198view11:15, 27 September 2022IsabelWassinkModified description
124197view11:05, 27 September 2022IsabelWassinkData node annotations updated
124194view13:30, 26 September 2022Mkutmonmaking groups instead of individual nodes
124064view10:44, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
124063view10:44, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer' added !
124062view10:43, 15 September 2022IsabelWassinkModified description
124061view10:42, 15 September 2022IsabelWassinkNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
COMetaboliteCHEBI:17245 (ChEBI)
CSF2GeneProductENSG00000164400 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL17CGeneProductENSG00000124391 (Ensembl)
IL17DGeneProductENSG00000172458 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
VEGFBGeneProductENSG00000173511 (Ensembl)
VEGFCGeneProductENSG00000150630 (Ensembl)
VEGFDGeneProductENSG00000165197 (Ensembl)

Annotated Interactions

No annotated interactions

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