Eicosanoid synthesis (Homo sapiens)

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14Cell MembranePGD2Leukotriene D4TBXAS1ALOX5Prostaglandin H2Thromboxane B2Prostaglandin F2aProstaglandin I2Leukotriene A4ALOX5APGGT1PTGDSPTGISDPEP1Leukotriene E4GSH peroxidaseALOX5APPRXL2BLTA4HProstaglandin D212S-HETEThromboxane A2ALOX15BAKR1C3CBR1PTGESALOX12PTGS25S-HETELTC4SPTGS1Leukotriene B4Arachidonic acidPer-oxidaseLeukotriene C415S-HETE5S-HPETEALOX5ALOX5ALOX15PTGES2212S-HPETE315S-HPETEProstaglandin E215-Dehydro-prostaglandin I2dehydrogenase4Thromboxane A3Pla2g5Phospholipids containgingarachidonic acidPla2g6Pla2g4aPla2g4bPtgs1Ptgs2PGG211-HETEALOX5PGJ215-deoxy-PGJ215-deoxy-PGD2Ptgs1Ptgs2


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia.

This pathway has been updated with information from LIPID MAPS>Eicosanoids [1]. Metabolites and proteins from this pathway are orange coloured and have an rounded rectangle shape (where an rectangle shape indicates that the node only occures in the LIPIDM APS pathway). Reactions occurring in the LIPID MAPS pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LIPID MAPS pathway).

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia
  2. Schieber A, Frank RW, Ghisla S; ''Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.''; Eur J Biochem, 1992 PubMed Europe PMC Scholia
  3. Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, Watanabe K; ''cDNA cloning, expression and characterization of human prostaglandin F synthase.''; FEBS Lett, 1999 PubMed Europe PMC Scholia
  4. Korff JM, Jarabak J; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124883view08:31, 22 December 2022EgonwModified description
124767view10:04, 10 December 2022EgonwFixed two datasources
124766view11:05, 9 December 2022Conroy lipids
124765view10:32, 9 December 2022Conroy lipidsmore conversion to uniprot, and remove duplication of AA formation from membrane lipids
124764view10:00, 9 December 2022Conroy lipidsstatdardise protein/geneproduct to uniprot (round 1)
124763view09:32, 9 December 2022Conroy lipidsadd rhea change arrows and sort out identity of HETE/HpETE lipids
124761view14:11, 8 December 2022Conroy lipidsadd more rheas to arachidonateremove spurious PNPLA3
124760view13:50, 8 December 2022Conroy lipidsadded rheas to prostaglandin H2 reactions, and converted arrows to mim-conversion
124733view15:29, 7 December 2022Conroy lipidsconvert arrows to mim-conversion and add rhea IDs to the leukotriene arm
120547view17:50, 14 December 2021Conroy lipidsupdate most lipids to lipidmaps identifiers
117707view12:26, 22 May 2021EweitzModified title
106700view13:09, 17 September 2019MaintBotHMDB identifier normalization
106398view21:30, 28 August 2019KhanspersModified description
105578view06:32, 9 August 2019KhanspersModified description
102907view10:58, 28 January 2019DeSlModified description
102906view10:56, 28 January 2019DeSlChanged layout slightly, and annotated 2 missing metabolites.
98574view15:40, 17 September 2018DeSlModified description
98571view15:39, 17 September 2018DeSlChanged layout, coloured outside of node orange.
98564view13:36, 17 September 2018DeSlModified description
98563view13:32, 17 September 2018DeSlChanged layout, removed node colour.
98452view12:49, 7 September 2018DeSlRemoved "last modified" item
98451view12:49, 7 September 2018DeSlModified description
98450view12:48, 7 September 2018DeSlSLight layout change
98449view12:47, 7 September 2018DeSlOne more ID.
98448view12:45, 7 September 2018DeSlAnnotated more nodes.
98447view12:41, 7 September 2018DeSlAdded more IDs to new LipidMaps content
98431view15:39, 6 September 2018DeSlAdded remaining lipids from lipidmaps
98430view15:24, 6 September 2018DeSlModified description
98429view15:23, 6 September 2018DeSlReverted to version '15:22, 6 September 2018' by DeSl
98428view15:23, 6 September 2018DeSlModified description
98427view15:22, 6 September 2018DeSlModified description
98426view15:22, 6 September 2018DeSlModified description
98425view15:21, 6 September 2018DeSlModified description
98424view15:19, 6 September 2018DeSlModified description
98423view15:18, 6 September 2018DeSlModified description
98422view15:13, 6 September 2018DeSlModified description
98421view15:10, 6 September 2018DeSlAdded info from LipidMaps PW.
89514view10:45, 16 September 2016Mkutmonontology tag fix
89469view13:39, 15 September 2016Mkutmonremove space from ontology term id
82702view07:46, 23 October 2015EgonwReplaced to CAS numbers with the ChEBI identifiers: 70608-72-9 cannot be 5-HETE, 12-HETE, and 15-HETE at the same time.
79809view16:44, 16 April 2015Mkutmonfixed unconnected line
71381view18:40, 17 October 2013MaintBotAutomated update of data sources
67184view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63178view20:30, 8 May 2013MaintBotUpdating gpml version
45234view17:44, 7 October 2011AlexanderPicoOntology Term : 'epithelial cell' added !
45226view17:36, 7 October 2011AlexanderPicoOntology Term : 'inflammatory response pathway' added !
45138view01:00, 7 October 2011AlexanderPicofixed reaction
45103view22:21, 6 October 2011AlexanderPicofixed reactions
45099view21:51, 6 October 2011AlexanderPicoupdated reactions
45098view21:46, 6 October 2011AlexanderPicoupdated refs and reactions

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-HETEMetaboliteLMFA03060085 (LIPID MAPS)
12S-HETEMetaboliteLMFA03060007 (LIPID MAPS)
12S-HPETEMetaboliteLMFA03060013 (LIPID MAPS)
15-Dehydro-prostaglandin I2MetaboliteLMFA03010205 (LIPID MAPS) Changed 15-oxo-prostaglandin I2 to 15-Dehydro-prostaglandin I2, since the enzyme listed mentions dehydrogenase, and pubchem mentions 15-Dehydro-prostaglandin I2 is created from Prostaglandin I2.
15-deoxy-PGD2MetaboliteLMFA03010051 (LIPID MAPS)
15-deoxy-PGJ2MetaboliteLMFA03010021 (LIPID MAPS)
15S-HETEMetaboliteLMFA03060001 (LIPID MAPS)
15S-HPETEMetaboliteLMFA03060014 (LIPID MAPS)
5S-HETEMetaboliteLMFA03060002 (LIPID MAPS)
5S-HPETEMetaboliteLMFA03060012 (LIPID MAPS)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL) EC:1.1.1.188
ALOX12GeneProductP18054 (Uniprot-TrEMBL)
ALOX15BGeneProductO15296 (Uniprot-TrEMBL)
ALOX15GeneProductP16050 (Uniprot-TrEMBL)
ALOX5APGeneProductP20292 (Uniprot-TrEMBL)
ALOX5GeneProductP09917 (Uniprot-TrEMBL)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
CBR1GeneProductP16152 (Uniprot-TrEMBL) 1.1.1.189
DPEP1GeneProductP16444 (Uniprot-TrEMBL)
GGT1GeneProductP19440 (Uniprot-TrEMBL)
GSH peroxidaseGeneProduct1.11.1.9 (Enzyme Nomenclature)
LTA4HGeneProductP09960 (Uniprot-TrEMBL)
LTC4SGeneProductQ16873 (Uniprot-TrEMBL)
Leukotriene A4MetaboliteLMFA03020023 (LIPID MAPS)
Leukotriene B4MetaboliteLMFA03020001 (LIPID MAPS)
Leukotriene C4MetaboliteLMFA03020003 (LIPID MAPS)
Leukotriene D4MetaboliteLMFA03020006 (LIPID MAPS)
Leukotriene E4MetaboliteLMFA03020002 (LIPID MAPS)
PGD2MetaboliteLMFA03010004 (LIPID MAPS)
PGG2MetaboliteLMFA03010009 (LIPID MAPS)
PGJ2MetaboliteLMFA03010019 (LIPID MAPS)
PRXL2BGeneProductQ8TBF2 (Uniprot-TrEMBL)
PTGDSGeneProductP41222 (Uniprot-TrEMBL)
PTGES2GeneProductQ9H7Z7 (Uniprot-TrEMBL)
PTGESGeneProductO14684 (Uniprot-TrEMBL)
PTGISGeneProductQ16647 (Uniprot-TrEMBL)
PTGS1GeneProductP23219 (Uniprot-TrEMBL)
PTGS2GeneProductP35354 (Uniprot-TrEMBL)
Per- oxidaseGeneProduct1.11.1.7 (Enzyme Nomenclature)
Phospholipids containging arachidonic acidMetaboliteCHEBI:37739 (ChEBI) AKA glycerophospholipids
Pla2g4aGeneProductP47712 (Uniprot-TrEMBL)
Pla2g4bGeneProductP0C869 (Uniprot-TrEMBL)
Pla2g5GeneProductP39877 (Uniprot-TrEMBL)
Pla2g6GeneProductO60733 (Uniprot-TrEMBL)
Prostaglandin D2MetaboliteLMFA03010004 (LIPID MAPS)
Prostaglandin E2MetaboliteLMFA03010003 (LIPID MAPS)
Prostaglandin F2aMetaboliteLMFA03010002 (LIPID MAPS)
Prostaglandin H2MetaboliteLMFA03010010 (LIPID MAPS)
Prostaglandin I2MetaboliteLMFA03010087 (LIPID MAPS)
Ptgs1GeneProductP23219 (Uniprot-TrEMBL)
Ptgs2GeneProductP35354 (Uniprot-TrEMBL)
TBXAS1GeneProductP24557 (Uniprot-TrEMBL)
Thromboxane A2MetaboliteLMFA03030001 (LIPID MAPS)
Thromboxane A3MetaboliteLMFA03030005 (LIPID MAPS)
Thromboxane B2MetaboliteLMFA03030002 (LIPID MAPS)
dehydrogenaseGeneProduct1.1.1.231 (Enzyme Nomenclature)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
12S-HPETE12S-HETEmim-conversion50709 (Rhea)
15S-HPETE15S-HETEmim-conversion48857 (Rhea)
5S-HPETE5S-HETEmim-conversion48621 (Rhea)
5S-HPETELeukotriene A4mim-conversion17962 (Rhea)
Arachidonic acid12S-HPETEmim-conversion10429 (Rhea)
Arachidonic acid15S-HPETEmim-conversion16870 (Rhea)
Arachidonic acid5S-HPETEmim-conversion17486 (Rhea)
Arachidonic acidPGG2mim-conversion42597 (Rhea)
Arachidonic acidProstaglandin H2mim-conversion23729 (Rhea)
Leukotriene A4Leukotriene B4mim-conversion22325 (Rhea)
Leukotriene A4Leukotriene C4mim-conversion17619 (Rhea)
Leukotriene C4Leukotriene D4mim-conversion31564 (Rhea)
Leukotriene D4Leukotriene E4mim-conversion48617 (Rhea)
PGG2Prostaglandin H2mim-conversion42601 (Rhea)
Prostaglandin D2Prostaglandin F2amim-conversion10142 (Rhea)
Prostaglandin E2Prostaglandin F2amim-conversion24510 (Rhea)
Prostaglandin H2Prostaglandin D2mim-conversion10601 (Rhea)
Prostaglandin H2Prostaglandin E2mim-conversion12894 (Rhea)
Prostaglandin H2Prostaglandin F2amim-conversion28215 (Rhea)
Prostaglandin H2Prostaglandin I2mim-conversion23581 (Rhea)
Prostaglandin H2Thromboxane A2mim-conversion17138 (Rhea)
Prostaglandin I215-Dehydro-prostaglandin I2mim-conversion21421 (Rhea)
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