Lactate shuttle in glial cells (Homo sapiens)

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HCO3-ATPNBC1pyruvateUDP-D-glucoseTCA cycleGlycolysisGLSH+SLC16A3CO2CAIVD-Glucose 1-phosphateglucoseNa+SLC16A7ADPlactateD-Glucose 6-phosphateSLC1A2Na+ K+ATPase OH-O2UDPGPPGlycogen synthesis and degradation CAIIGSSLC2A3glycogenK+PGM1NADPHHexokinaseglutaminePentose phosphate metabolismglutamateLDHANeuronammoniaSLC16A1lactatepyruvateLDHBglucoseADPGlycolysisATPADPCO2CAIIH+HCO3-H+CO2glucoseSLC2A1CAIVNa+SLC2A1AstrocyteCapillaryNeuronSynaptic cleftglutamateglutamateglutamineNa+HCO3-CAIIATPADPATPH+Na+K+K+ATPADPSLC2A1GLUR1GLUR2GLUR3GLUR4lactateH+


Description

Astrocyte-Neuron lactate shuttle (Homo sapiens) The pathway shows the relation between neuronal activity and lactate production in astrocytes.

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Bibliography

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  1. Ouyang, L., Tian, Y., Bao, Y., Xu, H., Cheng, J., Wang, B., Shen, Y., Chen, Z., & Lyu, J.; ''Carnosine decreased neuronal cell death through targeting glutamate system and astrocyte mitochondrial bioenergetics in cultured neuron/astrocyte exposed to OGD/recovery.''; https://doi.org/10.1016/j.brainresbull.2016.03.019, 2016 PubMed Europe PMC Scholia
  2. Siracusa, R., Fusco, R., & Cuzzocrea, S.; ''Astrocytes: Role and Functions in Brain Pathologies. Frontiers in Pharmacology,''; https://doi.org/10.3389/fphar.2019.01114, 2019 PubMed Europe PMC Scholia
  3. Brown, A. M., & Ransom, B. R.; ''Astrocyte glycogen and brain energy metabolism.''; https://doi.org/10.1002/glia.20557, 2007 PubMed Europe PMC Scholia
  4. Bröer, S. and Brookes, N.; ''Transfer of glutamine between astrocytes and neurons. ''; https://doi.org/10.1046/j.1471-4159.2001.00322.x, 2001 PubMed Europe PMC Scholia
  5. Valvona, C. J., Fillmore, H. L., Nunn, P. B., & Pilkington, G. J.; ''he Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.''; https://doi.org/10.1111/bpa.12299, 2015 PubMed Europe PMC Scholia
  6. Suzuki, A., Stern, Sarah A., Bozdagi, O., Huntley, George W., Walker, Ruth H., Magistretti, Pierre J., & Alberini, Cristina M.; ''Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation.''; https://doi.org/10.1016/j.cell.2011.02.018, 2011 PubMed Europe PMC Scholia
  7. Bélanger, M., Allaman, I., & Magistretti, Pierre J.; ''Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation.''; https://doi.org/10.1016/j.cmet.2011.08.016, 2011 PubMed Europe PMC Scholia
  8. Souza, A. de A., da Silva, G. S. S., Velez, B. S., Santoro, A. B. M., & Montero-Lomelí, M.; ''Glycogen synthesis in brain and astrocytes is inhibited by chronic lithium treatment.''; https://doi.org/10.1016/j.neulet.2010.07.016, 2010 PubMed Europe PMC Scholia
  9. Beard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C.; ''Astrocytes as Key regulators of brain energy metabolism: New therapeutic perspectives''; https://doi.org/10.3389/fphys.2021.825816, 2022 PubMed Europe PMC Scholia
  10. Stridh, M. H., Alt, M. D., Wittmann, S., Heidtmann, H., Aggarwal, M., Riederer, B., Seidler, U., Wennemuth, G., McKenna, R., Deitmer, J. W., & Becker, H. M.; ''Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II.''; https://doi.org/10.1113/jphysiol.2011.220152, 2012 PubMed Europe PMC Scholia
  11. Koch, H., & Weber, Y. G.; ''he glucose transporter type 1 (Glut1) syndromes. Epilepsy & Behavior''; https://doi.org/10.1016/j.yebeh.2018.06.010, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134484view03:11, 22 July 2024EweitzOntology Term : 'neuron' added !
134483view03:10, 22 July 2024EweitzOntology Term : 'astrocyte' added !
134382view15:51, 21 July 2024EweitzModified description
129352view09:28, 27 March 2024MkutmonOntology Term : 'classic metabolic pathway' added !
125793view11:20, 10 March 2023DeSlConverted synaptic cleft DataNode to textLabel
125792view11:17, 10 March 2023DeSlRemoving 'Unknown' DataNodes, replaces with labels in graphical drawings
125568view22:54, 27 February 2023AlexanderPicoSe
125549view21:20, 26 February 2023AndraOntology Term : 'glial cell' added !
125526view17:06, 25 February 2023EgonwMade five pathways clickable
125268view13:51, 31 January 2023Ellaverheggensources
125267view13:38, 31 January 2023Ellaverheggensources
125228view13:09, 30 January 2023Ellaverheggendescription change
125225view11:40, 30 January 2023Cleopheebruchouupdate reaction
125202view13:07, 29 January 2023Cleopheebruchoudescription
125201view13:06, 29 January 2023CleopheebruchouDescription
125199view12:30, 29 January 2023Cleopheebruchouadded external references
125188view12:30, 27 January 2023CleopheebruchouChanging arrows
125173view14:08, 26 January 2023Cleopheebruchouupdated transporter names
125171view14:05, 26 January 2023Cleopheebruchouupdated reaction arrows
125132view16:56, 24 January 2023Celestecurreriaddition of ATPase
125131view16:40, 24 January 2023Celestecurrerichange arrows and receptors/transporters name
125129view16:36, 24 January 2023Ellaverheggencheck arrows and glutamine/glutamate uptake
125107view11:08, 23 January 2023Cleopheebruchoutransporter name
125100view00:39, 23 January 2023EweitzModified title
125082view13:50, 20 January 2023Ellaverheggenadded glutamate and glutamine uptake cycle
125072view13:45, 19 January 2023Ellaverheggentrial
125068view14:45, 18 January 2023CelestecurreriAdding colors
125064view11:21, 18 January 2023CelestecurreriAdding glut3
125052view12:25, 17 January 2023CleopheebruchouComplete pathway
125040view10:16, 17 January 2023CelestecurreriNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
Astrocyte
CAIIProteinP00918 (Uniprot-TrEMBL)
CAIVProteinP22748 (Uniprot-TrEMBL)
CO2MetaboliteCHEBI:16526 (ChEBI)
Capillary
D-Glucose 1-phosphateMetaboliteCHEBI:16077 (ChEBI)
D-Glucose 6-phosphateMetaboliteCHEBI:4170 (ChEBI)
GLSProteino94925 (Uniprot-TrEMBL)
GLUR1Proteinp42261 (Uniprot-TrEMBL)
GLUR2Proteinp42262 (Uniprot-TrEMBL)
GLUR3Proteinp42263 (Uniprot-TrEMBL)
GLUR4Proteinp480458 (Uniprot-TrEMBL)
GSProteinp15104 (Uniprot-TrEMBL)
Glycogen synthesis

and degradation

PathwayWP500 (WikiPathways)
GlycolysisPathwayWP4629 (WikiPathways)
H+MetaboliteCHEBI:15378 (ChEBI)
HCO3-MetaboliteCHEBI:17544 (ChEBI)
HexokinaseProteinP19367 (Uniprot-TrEMBL)
K+MetaboliteCHEBI:29103 (ChEBI)
LDHAGeneProductENSG00000134333 (Ensembl)
LDHBGeneProductP07195 (Uniprot-TrEMBL)
NADPHMetaboliteHMDB00221 (HMDB)
NBC1ProteinQ9Y6R1 (Uniprot-TrEMBL)
Na+ K+ ATPase Proteinp50993 (Uniprot-TrEMBL)
Na+MetaboliteCHEBI:29101 (ChEBI)
Neuron
O2MetaboliteCHEBI:15379 (ChEBI)
OH-MetaboliteCHEBI:16234 (ChEBI)
PGM1ProteinGene ID: 5236 (NCBI Protein)
Pentose phosphate metabolismPathwayWP134 (WikiPathways)
SLC16A1ProteinP53985 (Uniprot-TrEMBL)
SLC16A3ProteinO15427 (Uniprot-TrEMBL)
SLC16A7ProteinO60669 (Uniprot-TrEMBL)
SLC1A2ProteinP43004 (Uniprot-TrEMBL)
SLC2A1ProteinP11166 (Uniprot-TrEMBL)
SLC2A3ProteinP11169 (Uniprot-TrEMBL)
Synaptic cleft
TCA cyclePathwayWP78 (WikiPathways)
UDP-D-glucoseMetaboliteCHEBI:18066 (ChEBI)
UDPGPPProteinO95848 (Uniprot-TrEMBL)
ammonia MetaboliteCHEBI:16134 (ChEBI)
glucoseMetaboliteCHEBI:17234 (ChEBI)
glutamateMetaboliteCHEBI:14321 (ChEBI)
glutamineMetaboliteCHEBI:28300 (ChEBI)
glycogenMetaboliteCHEBI:28087 (ChEBI)
lactateMetaboliteCHEBI:24996 (ChEBI)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions
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