This pathway was constructed based on the Brown et al 2021 book chapter (Cholesterol Synthesis), combined with the Reactome Cholesterol Synthesis pathway (DOI:10.3180/R-HSA-191273.7) and the WikiPathways WP4718 (Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (Homo sapiens)). Additional information was incorporated based on the literature. All protein were curated for cell-specific (hepatocyte) isoforms.
Song BL, Javitt NB, DeBose-Boyd RA; ''Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.''; Cell Metab, 2005 PubMedEurope PMCScholia
Brown, Andrew J., W. Coates, Hudson, J. Sharpe, Laura; ''Chapter 10 - Cholesterol synthesis''; Biochemistry of Lipids, Lipoproteins and Membranes (Seventh Edition) , 2021
Rudney H, Sexton RC; ''Regulation of cholesterol biosynthesis.''; Annu Rev Nutr, 1986 PubMedEurope PMCScholia
Russell DW; ''Cholesterol biosynthesis and metabolism.''; Cardiovasc Drugs Ther, 1992 PubMedEurope PMCScholia
Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMedEurope PMCScholia
Herman GE; ''Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.''; Hum Mol Genet, 2003 PubMedEurope PMCScholia
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
IDI2 might catalize this reaction as well, however ther is no data supporting its occurrence in hepatocytes.
https://www.proteinatlas.org/ENSG00000148377-IDI2/tissue/liver
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.
The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex.
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
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