Cell cycle (Homo sapiens)

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1S-phase proteins,Cyclin EOrigin recognitioncomplexG1DNA damage checkpointSR-point(start)CohesinGrowth factorSecurin+pGrowth factor withdrawalMG2SeparinCDC7CDK7PLK1CDKN2AMAD2L2PCNACDK2PGSK3BESPL1MCM2TP53PPPCDC25BPCC14BCCNA1CCNA2RB1HDAC1MAD1L1RBL1RBL2PPPPPCDC45ATMTGFB1CCNHPTTG1CHK2PPPCDK1PPPPKMYT1MAPK signaling pathwayCDC20SMAD4CCNE1CDC25CApoptosisABL1RB1CCNE2ATRSFNHDAC2PTTG2FZR1PSKP1YWHABCDK2PGADD45ACDK6CDC6PPPEP300CDKN1CPSKP2CCND2PBUB3YWHAERB1PYWHAHCCNB3YWHAQCC14AYWHAZDBF4AMCM3WEE1MCM4DNA biosynthesisMCM5CDK4MCM6PRKDCMCM7ANAPC10ORC1CDKN1AORC2CCNA2ORC3SMAD3ORC4SMC3ORC5MDM2ORC6Ubiquitin-mediated proteolysisSMAD2BUB1TGFB2CCND3TGFB3PCCNB2RBL1YWHAGE2F4CCNB1E2F5CDK1TFDP1CHK1PTFDP2PCDKN2AMYCCCNA1ZBTB17CDKN2BCDKN2CCDKN2DCCND1PCDKN1BPCUL1RBX1E2F1E2F2TFDP1E2F3TFDP2E2F4E2F5TFDP1TFDP2GADD45BGADD45GCDC25APTTKMD1L1PSMC1BSMC1ASTAG1STAG2RAD21WEE2ANAPC13ANAPC2ANAPC4ANAPC5ANAPC7ANAPC11ANAPC1CDC23CDC16CDC27CDC20ANAPC10ANAPC13ANAPC2ANAPC4ANAPC5ANAPC7ANAPC11ANAPC1CDC23CDC16CDC27SKP1SKP2CUL1RBX1ORC1ORC2ORC3ORC4ORC5ORC6MCM2MCM3MCM4MCM5MCM6MCM7Minichromosome maintenance complex


Description

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Sources: Wikipedia:Cell cycle, KEGG

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127277view15:52, 1 September 2023Khanspersfixed phospho site
127262view04:52, 30 August 2023Khanspersadded phospho sites
127255view18:16, 28 August 2023Khanspersadded lliterature reference and updated description
127172view06:20, 9 August 2023Fehrhartbox for pathway
127158view23:32, 7 August 2023Khanspersupdated ptms
122978view19:12, 8 June 2022Mkutmonfix unconnected pathway node
122977view19:09, 8 June 2022Mkutmonremoved empty groups
120742view23:40, 27 December 2021EweitzRefine graphics, text; use gene symbols
120027view22:50, 15 October 2021Khanspersupdate phosphosites
120026view20:26, 15 October 2021Khanspersupdate phosphosites
120025view20:12, 15 October 2021Khanspersupdate phosphosites
120024view19:57, 15 October 2021Khanspersupdated phosphosites
116693view15:31, 9 May 2021EweitzModified title
114261view13:57, 2 January 2021EgonwThree more pathways clickable
112039view17:58, 16 September 2020Khanspersupdated phospho site
106351view21:36, 21 August 2019KhanspersModified description
105448view04:58, 8 August 2019KhanspersModified description
105235view13:42, 23 July 2019EgonwNo gene-gene conversion.
103430view16:00, 28 February 2019DeSlRemoved last modified item
97174view17:12, 3 May 2018AlexanderPicochanged complex to paralog group
96994view21:13, 25 April 2018Khanspersadded phosphosites
96993view20:19, 25 April 2018Khanspersinteractions and phosphosites
96985view05:19, 25 April 2018Khanspersoverhaul: updated to Ensembl, added phoshposites, complexes etc
96984view01:20, 25 April 2018Khanspersoverhaul in progress
96983view23:29, 24 April 2018Khanspersoverhaul in progress
93002view18:31, 21 July 2017KhanspersReverted to version '10:59, 16 September 2016' by Khanspers
92878view08:44, 13 July 2017JosipMadunicCell Cycle
89516view10:59, 16 September 2016Mkutmonontology tag fix
89470view13:39, 15 September 2016Mkutmonremove space from ontology term id
70629view00:22, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
69900view19:28, 11 July 2013AlexanderPicoModified title
67101view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
63158view20:18, 8 May 2013MaintBotUpdating gpml version
59175view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45137view00:58, 7 October 2011AlexanderPico
45136view00:57, 7 October 2011AlexanderPicoModified description
45135view00:56, 7 October 2011AlexanderPicoModified description
45134view00:56, 7 October 2011AlexanderPicoModified description
45133view00:55, 7 October 2011AlexanderPicoModified description
45089view21:00, 6 October 2011AlexanderPico
45087view20:58, 6 October 2011AlexanderPicodb refs
45084view20:51, 6 October 2011AlexanderPicofixed pathway refs
45079view20:41, 6 October 2011AlexanderPicoadded groups
45075view20:31, 6 October 2011AlexanderPicoadded groups and db refs
45071view20:14, 6 October 2011AlexanderPicoadded db ref and group
41134view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
35361view09:11, 12 February 2010MartijnVanIerselModified description
34663view12:07, 8 January 2010ThomasReverted color change of gene boxes by BadrulYahaya (no meaning for the color provided)
32357view13:40, 15 August 2009MaintBotFixed text labels
31988view13:13, 14 August 2009MaintBotFixed group labels

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSG00000097007 (Ensembl) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
ANAPC10GeneProductENSG00000164162 (Ensembl)
ANAPC11GeneProductENSG00000141552 (Ensembl)
ANAPC13GeneProductENSG00000129055 (Ensembl)
ANAPC1GeneProductENSG00000153107 (Ensembl)
ANAPC2GeneProductENSG00000176248 (Ensembl)
ANAPC4GeneProductENSG00000053900 (Ensembl)
ANAPC5GeneProductENSG00000089053 (Ensembl)
ANAPC7GeneProductENSG00000196510 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProductENSG00000175054 (Ensembl) ATR; ataxia telangiectasia and Rad3 related
ApoptosisPathwayWP254 (WikiPathways)
BUB1GeneProductENSG00000169679 (Ensembl) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB3GeneProductENSG00000154473 (Ensembl) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
CC14AGeneProductENSG00000079335 (Ensembl) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CC14BGeneProductENSG00000081377 (Ensembl) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CCNA1GeneProductENSG00000133101 (Ensembl) CCNA1; cyclin A1
CCNA2GeneProductENSG00000145386 (Ensembl) CCNA2; cyclin A2
CCNB1GeneProductENSG00000134057 (Ensembl) CCNB1; cyclin B1
CCNB2GeneProductENSG00000157456 (Ensembl) CCNB2; cyclin B2
CCNB3GeneProductENSG00000147082 (Ensembl) CCNB3; cyclin B
CCND1GeneProductENSG00000110092 (Ensembl) CCND3; cyclin D3
CCND2GeneProductENSG00000118971 (Ensembl) CCND2; cyclin D2
CCND3GeneProductENSG00000112576 (Ensembl) CCND3; cyclin D3
CCNE1GeneProductENSG00000105173 (Ensembl) CCNE1; cyclin E
CCNE2GeneProductENSG00000175305 (Ensembl) CCNE2; cyclin E
CCNHGeneProductENSG00000134480 (Ensembl) CCNH; cyclin H
CDC16GeneProductENSG00000130177 (Ensembl)
CDC20GeneProduct991 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC23GeneProductENSG00000094880 (Ensembl)
CDC25AGeneProductENSG00000164045 (Ensembl) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
CDC25BGeneProductENSG00000101224 (Ensembl) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC25CGeneProductENSG00000158402 (Ensembl) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC27GeneProductENSG00000004897 (Ensembl)
CDC45GeneProductENSG00000093009 (Ensembl) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProductENSG00000094804 (Ensembl) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProductENSG00000097046 (Ensembl) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDK1GeneProductENSG00000170312 (Ensembl) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDK2GeneProductENSG00000123374 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProductENSG00000135446 (Ensembl) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProductENSG00000105810 (Ensembl) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDK7GeneProductENSG00000134058 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1CGeneProductENSG00000129757 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProductENSG00000147889 (Ensembl)
CDKN2BGeneProductENSG00000147883 (Ensembl)
CDKN2CGeneProductENSG00000123080 (Ensembl)
CDKN2DGeneProductENSG00000129355 (Ensembl)
CHK1GeneProduct1111 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHK2GeneProduct11200 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CUL1GeneProductENSG00000055130 (Ensembl)
DBF4AGeneProductENSG00000006634 (Ensembl) ASK; activator of S phase kinas
DNA biosynthesisPathway
E2F1GeneProductENSG00000101412 (Ensembl) E2F1; E2F transcription factor 1
E2F2GeneProductENSG00000007968 (Ensembl) E2F2; E2F transcription factor 2
E2F3GeneProductENSG00000112242 (Ensembl) E2F3; E2F transcription factor 3
E2F4GeneProductENSG00000205250 (Ensembl) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProductENSG00000133740 (Ensembl) E2F5; E2F transcription factor 5 p130-binding
EP300GeneProductENSG00000100393 (Ensembl) EP300; E1A binding protein p300
ESPL1GeneProductENSG00000135476 (Ensembl) ESPL1; extra spindle poles like 1 (S. cerevisiae
FZR1GeneProductENSG00000105325 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
HDAC1GeneProductENSG00000116478 (Ensembl) HDAC1; histone deacetylase 1
HDAC2GeneProductENSG00000196591 (Ensembl) HDAC2; histone deacetylase 2
MAD1L1GeneProductENSG00000002822 (Ensembl) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L2GeneProductENSG00000116670 (Ensembl) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MAPK signaling pathwayPathwayWP382 (WikiPathways)
MCM2GeneProductENSG00000073111 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM3GeneProductENSG00000112118 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM4GeneProductENSG00000104738 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM5GeneProductENSG00000100297 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM6GeneProductENSG00000076003 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MCM7GeneProductENSG00000166508 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
MD1L1GeneProductENSG00000002822 (Ensembl) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MDM2GeneProductENSG00000135679 (Ensembl) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MYCGeneProductENSG00000136997 (Ensembl)
ORC1GeneProductENSG00000085840 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC2GeneProductENSG00000115942 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC3GeneProductENSG00000135336 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC4GeneProductENSG00000115947 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC5GeneProductENSG00000164815 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
ORC6GeneProductENSG00000091651 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
PCNAGeneProductENSG00000132646 (Ensembl) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProductENSG00000127564 (Ensembl) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProductENSG00000166851 (Ensembl) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProductENSG00000253729 (Ensembl) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProductENSG00000164611 (Ensembl) PTTG1; pituitary tumor-transforming
PTTG2GeneProductENSG00000250254 (Ensembl) PTTG2; pituitary tumor-transforming
RAD21GeneProductENSG00000164754 (Ensembl) ESPL1; extra spindle poles like 1 (S. cerevisiae
RB1GeneProductENSG00000139687 (Ensembl)
RBL1GeneProductENSG00000080839 (Ensembl)
RBL2GeneProductENSG00000103479 (Ensembl) RB1; retinoblastoma 1 (including osteosarcoma)
RBX1GeneProductENSG00000100387 (Ensembl)
SFNGeneProductENSG00000175793 (Ensembl) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
SKP1GeneProductENSG00000113558 (Ensembl)
SKP2GeneProductENSG00000105810 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
SKP2GeneProductENSG00000145604 (Ensembl) SKP2; S-phase kinase-associated protein 2 (p45
SMAD2GeneProductENSG00000175387 (Ensembl) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD3GeneProductENSG00000166949 (Ensembl) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProductENSG00000141646 (Ensembl) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProductENSG00000072501 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
SMC1BGeneProductENSG00000077935 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
SMC3GeneProductENSG00000108055 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG1GeneProductENSG00000118007 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG2GeneProductENSG00000101972 (Ensembl) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TFDP1GeneProductENSG00000198176 (Ensembl) TFDP1; transcription factor Dp-1
TFDP2GeneProductENSG00000114126 (Ensembl) TFDP1; transcription factor Dp-1
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TTKGeneProductENSG00000112742 (Ensembl) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
WEE1GeneProductENSG00000166483 (Ensembl) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
WEE2GeneProductENSG00000214102 (Ensembl) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHABGeneProduct7529 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
YWHAGGeneProduct7532 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)
ZBTB17GeneProductENSG00000116809 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP179"
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