PDGFR-beta pathway (Homo sapiens)
From WikiPathways
Description
Simplified PDGFR-beta pathway, based on figure 7B from Zhang et al: https://www.ncbi.nlm.nih.gov/pubmed/27372738
Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Source: Wikipedia
Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.Quality Tags
Ontology Terms
Saving...Bibliography
- Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IeM, Cope L, Pandey A, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD; ''Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.''; Cell, 2016 PubMed Europe PMC Scholia
- Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
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Annotated Interactions
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