Omega-6-fatty acids in senescence (Homo sapiens)

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158. Petrie JR, Shrestha P, Liu Q, Mansour MP, Wood CC, Zhou XR, Nichols PD, Green AG, Singh SP; ''Rapid expression of transgenes driven by seed-specific constructs in leaf tissue: DHA production.''; Plant Methods, 2010 PubMed Europe PMC Scholia
159. Peiqing Sun, Naoto Yoshizuka, Liguo New, Bettina A. Moser, Yilei Li, Rong Liao, Changchuan Xie, Jianming Chen, Qingdong Deng, Maria Yamout, Meng-Qiu Dong, Costas G. Frangou, John R. Yates III, Peter E. Wright, Jiahuai Han; ''PRAK Is Essential for ras-Induced Senescence and Tumor Suppression''; ScienceDirect, 2007 PubMed Europe PMC Scholia
160. Biringer RG; ''A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia
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History

External references

DataNodes

Name	Type	Database reference	Comment
11,15-dioxo-9α-hydroxy-, 2,3,4,5-tetranorprostan-1,20-dioic acid*	Metabolite
11-Deyhdro-Thromboxane B2	Metabolite	CHEBI:28667 (ChEBI)
11-OH-dehydrogenase		EC 1.2.1.3 (Enzyme Nomenclature)
11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-PGE2*	Metabolite
11-hydroxy-9,15-dioxo-prost-5-en-1,20-dioic acid*	Metabolite
12LOX
13,14-dihydro-15-keto-PGA2	Metabolite	CHEBI:89315 (ChEBI)	8: Prostanoid Metabolites as Biomarkers in Human Disease Helena Idborg; Sven-Christian Pawelzik. 2022. PubMed 36005592.
13,14-dihydro-15-keto-PGD2	Metabolite	CHEBI:72603 (ChEBI)	DK-PGD2
13,14-dihydro-15-keto-PGE2	Metabolite	CHEBI:15550 (ChEBI)	PGEM= Metabolites downstream of PGE2
13,14-dihydro-PGE2*	Metabolite
13,14-dihydro-PGF2a	Metabolite	88346 (ChEBI)
13s, 14s epoxide Maresins	Metabolite
14s HpDHA	Metabolite
15-PGDH	GeneProduct	EC 1.1.1.141 (Enzyme Nomenclature)	15-PGDH=15-hydroxy-prostaglandin dehydrogenase
15-deoxy-Δ12,14-PGD2	Metabolite	CHEBI:63999 (ChEBI)	=15d-PGJ2
15-deoxy-Δ12,14-PGJ2	Metabolite	34159 (ChEBI)	=15d-PGJ2
15-hydroxy PG dehydrogenase* prostaglandin Δreductase* β-oxidase*	GeneProduct
15-keto-13,14-dihydro-8-iso-PGF2a	Metabolite	191919-02-5 (CAS)
15-keto-13,14-dihydro-PGE1	Metabolite	134499 (ChEBI)
15-keto-13,14-dihydro-PGE1	Metabolite	CHEBI:134499 (ChEBI)
15-keto-13,14-dihydro-PGF2a	Metabolite	63976 (ChEBI)
15-keto-8-iso-PGF2a	Metabolite	191919-01-4 (CAS)
15-keto-PGD2	Metabolite	CHEBI:15557 (ChEBI)
15-keto-PGE1	Metabolite	22973-19-9 (CAS)
15-keto-PGE2	Metabolite	15547 (ChEBI)
15-keto-PGF2a	Metabolite	CHEBI:28442 (ChEBI)
15-keto-PGI2	Metabolite	CHEBI:15556 (ChEBI)	=15-dehydro-Prostaglandin I2
15-ketoprostaglandin reductase	GeneProduct	EC 1.3.1.48 (Enzyme Nomenclature)
15LOX
19-OH-6-keto-PGF1a	Metabolite	172589 (ChEBI)
19-OH-PGE1	Metabolite	55123-67-6 (CAS)
19-OH-PGE2	Metabolite	CHEBI:165313 (ChEBI)
19-OH-PGH2*	Metabolite
2,3 dinor-6-keto-PGF1a*	Metabolite	73944 (ChEBI)
2,3-Dinor-Thromboxane B2	Metabolite	CHEBI:89991 (ChEBI)
2,3-dinor 6-keto pentanor*	Metabolite
2,3-dinor-11β-PGF2*	Metabolite	CHEBI:165323 (ChEBI)
2,3-dinor-5,6-dihydro-8-IsoPGF2a	Metabolite
2,3-dinor-8-IsoPGF2a	Metabolite
20-OH-LTB4	Metabolite	CHEBI:15646 (ChEBI)
4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid*	Metabolite		4,13-diketo-7,9-dihydroxy-2,3-dinor prostanoic acid =dinor-6,15-diketo-9,11-dihydroxy prostanoic acid
5-HETE	Metabolite
5-HPETE	Metabolite	HMDB11135 (HMDB)
5-series leukotrienes	Pathway
5α,7α-dihydroxy-11-keto tetranor-prostane-1,16-dioic acid*	Metabolite
6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a*	Metabolite		6,15-Diketo-13,14-dihydro-2,3-dinor PGF1a = 15 kd dinor
6,15-Diketo-13,14-dihydro-PGF1a*	Metabolite	CHEBI:72595 (ChEBI)
6,15-diketo PGF1a	Metabolite
6-keto-PGE1	Metabolite	28269 (ChEBI)
6-keto-PGF1a	Metabolite	28158 (ChEBI)
6-trans-LTB4	Metabolite	CHEBI:63981 (ChEBI)
7α-hydroxy-5,11-diketo-tetranorprosta-1,16-dioc acid*	Metabolite
8-iso-13,14-dihydro-15-keto-PGE2*	Metabolite
8-iso-PGF2a	Metabolite	27415-26-5 (CAS)	8-Isoprostane=8-epi-Prostaglandin F2alpha
9,15-dideoxy-Δ9,12,14-PGD2*	Metabolite
9-deoxy-Δ12-PGD2*	Metabolite	175297 (ChEBI)
9-hydroxyprostaglandin dehydrogenase	GeneProduct
9a, 11a-dihydroxy-11-keto-2,3,4,5-tetranorprostane-1,16-dioic acid*	Metabolite
9alpha,11alpha-PGF2a	Metabolite	CHEBI:15553 (ChEBI)
9alpha,11beta-PGF2	Metabolite	15553 (ChEBI)
9α, 11β-dihydroxy-15-oxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid*	Metabolite
A2-IsoP	Metabolite		Iso-Prostaglandin A2
ABCC4	GeneProduct	ENSG00000125257 (Ensembl)
AKR1B1	GeneProduct	ENSG00000085662 (Ensembl)	=aldo-keto reductase family 1 member B
AKR1C3	GeneProduct	ENSG00000196139 (Ensembl)	=NADPH-dependent PGD2 11-ketoreductase =aldo-keto reductase family 1 member C3 =EC 1.1.1.188
ALOX12
ALOX15
ALOX5	GeneProduct	ENSG00000012779 (Ensembl)	=arachidonate 5-lipoxygenase
Adrenic acid (22:4,w6)	Metabolite	53487 (ChEBI)
Albumin-mediated degradation	Complex
Arachidonic Acid (20:4,w6)	Metabolite	15843 (ChEBI)
Beta-oxidation
CYP4F8	GeneProduct	ENSG00000186526 (Ensembl)	=cytochrome P450 family 4 subfamily F member 8
CYP8A1	GeneProduct	ENSG00000124212 (Ensembl)	=prostaglandin I2 synthase =PTGIS
Ca2+			calcium
Carbonyl reductase*	GeneProduct
Cell Cycle Arrest Senescence	Pathway
CysLT1R	Protein	Q9Y271 (Uniprot-TrEMBL)	=cysteinyl leukotriene type 1 receptor
Cytosolic phospholipase A2	Protein	P47712 (Uniprot-TrEMBL)
D-series resolvins	Pathway
D2-IsoK	Metabolite		D2-Isoketals
D2-IsoP	Metabolite		Iso-Prostaglandin D2
DH-15d-Δ12,14-PGD2	Metabolite	CHEBI:165317 (ChEBI)
DH-PGD2*	Metabolite
DH-PGE2	Metabolite	CHEBI:185711 (ChEBI)
DH-PGF1a*	Metabolite
DH-PGF2a	Metabolite	CHEBI:183014 (ChEBI)
DH-PGG2*	Metabolite
DH-PGH2*	Metabolite
DH-PGI2	Metabolite	CHEBI:165328 (ChEBI)
DH-PGJ2	Metabolite	CHEBI:165318 (ChEBI)
DH-TxA2*	Metabolite
DH-TxB*	Metabolite
DP1	Complex		DP=D prostanoid receptors DP1, a member of the prostanoid family of G protein-coupled receptors, mediates the vasorelaxant and bronchodilator effects. DP2, a G protein-coupled receptor that regulates Th1 and Th2 switching in lymphocytes and is also expressed on eosinophils and basophils. binds and activates two distinct receptors: DP1 (via Gα(s) → AC) as well as DP2
DP2	Complex		DP=D prostanoid receptors DP1, a member of the prostanoid family of G protein-coupled receptors, mediates the vasorelaxant and bronchodilator effects. DP2, a G protein-coupled receptor that regulates Th1 and Th2 switching in lymphocytes and is also expressed on eosinophils and basophils
DPEP	GeneProduct
DPEP1	GeneProduct	ENSG00000015413 (Ensembl)	=Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11]
DPEP2	GeneProduct	ENSG00000167261 (Ensembl)
Dehydrase	GeneProduct
Dehydration
Dihomo-15d-PGJ2	Metabolite	16061095 (PubChem-compound)	=1a,1b-dihomo-15-deoxy-Δ12,14-prostaglandin J2
Dihomo-y-linolenic acid (DGLA) (20:3,w6)	Metabolite		= 8,11,14-Eicosatrienoic acid =DGLA
Dinor-4,13-diketo-7,9-dihydroxy-prostan-1,18-dioic acid*	Metabolite
Dinor-4,13-diketo-7,9-dihydroxy-prostanoic acid*	Metabolite
Dinor-4-keto-7,9,13-trihydroxy-prosta-11,12-enoic acid*	Metabolite
Docosahexaenoic acid (DHA) (22:6,w3)	Metabolite	CHEBI:36005 (ChEBI)
Docosapentaenoic acid (DPA) (22:5,w3)	Metabolite	CHEBI:53488 (ChEBI)
E series resolvins	Pathway
E2-IsoK	Metabolite		E2-Isoketals
E2-IsoP	Metabolite		Iso-Prostaglandin E2
EETs	Pathway
ELOVL2	GeneProduct	ENSG00000197977 (Ensembl)	fatty acid elongase 2
ELOVL5	GeneProduct	ENSG00000012660 (Ensembl)	fatty acid elongase 5
ELOVL5	GeneProduct	ENSG00000012660 (Ensembl Human)	fatty acid elongase 5
EP1	Complex		PGE2 interacts and exerts its effects through four distinct receptor subtypes on the cell membrane: EP1, EP2, EP3, and EP4. PGE2 can exert its multiple effects by interacting with one of four classes of receptors, EP1, EP2, EP3, or EP4. Interactions with these receptors elevate (EP2 and EP4) or depress (EP3) intracellular levels of cAMP or increase intracellular calcium (EP1). The EP2 and EP4 receptors are linked to stimulation of cyclic AMP (cAMP) and protein kinase A (PKA) signaling through sequential activation of Gαs and adenylate cyclase (AC). EP4 can also activate phosphoinositide-3-kinase (PI3K) through Gαi. The EP1 receptor leads to elevation of intracellular calcium through Gαq. EP3 act to inhibit cAMP generation via Gαi.
EP2	Complex		PGE2 interacts and exerts its effects through four distinct receptor subtypes on the cell membrane: EP1, EP2, EP3, and EP4. PGE2 can exert its multiple effects by interacting with one of four classes of receptors, EP1, EP2, EP3, or EP4. Interactions with these receptors elevate (EP2 and EP4) or depress (EP3) intracellular levels of cAMP or increase intracellular calcium (EP1). The EP2 and EP4 receptors are linked to stimulation of cyclic AMP (cAMP) and protein kinase A (PKA) signaling through sequential activation of Gαs and adenylate cyclase (AC). EP4 can also activate phosphoinositide-3-kinase (PI3K) through Gαi. The EP1 receptor leads to elevation of intracellular calcium through Gαq. EP3 act to inhibit cAMP generation via Gαi.
EP3	Complex		PGE2 interacts and exerts its effects through four distinct receptor subtypes on the cell membrane: EP1, EP2, EP3, and EP4. PGE2 can exert its multiple effects by interacting with one of four classes of receptors, EP1, EP2, EP3, or EP4. Interactions with these receptors elevate (EP2 and EP4) or depress (EP3) intracellular levels of cAMP or increase intracellular calcium (EP1). The EP2 and EP4 receptors are linked to stimulation of cyclic AMP (cAMP) and protein kinase A (PKA) signaling through sequential activation of Gαs and adenylate cyclase (AC). EP4 can also activate phosphoinositide-3-kinase (PI3K) through Gαi. The EP1 receptor leads to elevation of intracellular calcium through Gαq. EP3 act to inhibit cAMP generation via Gαi.
EP4	Complex		gene=Ptger4
Eicosadienoic acid (20:2,w6)	Metabolite
Eicosapentaenoic acid (EPA) (20:5,w3)	Metabolite
Eicosatetraenoic acid (ETA) (20:4,w3)	Metabolite	CHEBI:166893 (ChEBI)
Eicosatrienoic acid (20:3,w3)	Metabolite	5312529 (PubChem-compound)
Elongase	GeneProduct
Enzymatic β and w oxidation*
Excretion	Pathway
Excretion via urine	Pathway
FADS1	GeneProduct	ENSG00000149485 (Ensembl)	Δ5-Desaturase
FADS2	GeneProduct	ENSG00000134824 (Ensembl)	gene=FADS2 Δ6-Desaturase
FLAP	GeneProduct	ENSG00000132965 (Ensembl)	gene = ALOX5AP FLAP= 5-lipoxygenase activating protein
FP	Complex		Prostaglandin F receptor : FP Activation of FP by PGF2α results in the IP3 and DAG formation as well as in the mobilization of Ca2+.
Free radical-catalyzed peroxidation
G2-IsoP	Metabolite		Iso-Prostaglandin G2
GGT	GeneProduct
GGT1	GeneProduct	ENSG00000100031 (Ensembl)
GGT5	GeneProduct	ENSG00000099998 (Ensembl)	=gamma-glutamyltransferase 5
GSTM4s/LTC4s	GeneProduct
Gi	Complex
Gq	Complex
Gs	Complex		PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores
H-PGDS	GeneProduct	ENSG00000163106 (Ensembl)
H2-IsoP	Metabolite		Iso-Prostaglandin H2
HETEs	Pathway
HPGD	GeneProduct	ENSG00000164120 (Ensembl)	15-PGDH=15-hydroxy-prostaglandin dehydrogenase
IP	Complex		PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores
IP3	Complex
Irradiation-induced Senescence	Pathway
Irradiation-induced Senescence Oncogene-induced senescence (RAS)	Pathway
Isofuranes	Pathway
Isoprostanes	Pathway
J2-IsoP	Metabolite		Iso-Prostaglandin J2
L-PGDS	GeneProduct	ENSG00000107317 (Ensembl)
LGD2	Metabolite	CHEBI:34820 (ChEBI)	Levuglandin D2
LGE2	Metabolite	CHEBI:34821 (ChEBI)	Levuglandin E2
LGR6 receptor	Metabolite
LTA4	Metabolite	CHEBI:15651 (ChEBI)
LTA4H	GeneProduct	ENSG00000111144 (Ensembl)
LTB4	Metabolite	CHEBI:15647 (ChEBI)
LTC4	Metabolite	CHEBI:16978 (ChEBI)
LTC4S	GeneProduct	ENSG00000213316 (Ensembl)
LTD4	Metabolite	CHEBI:28666 (ChEBI)
LTE4	Metabolite	CHEBI:15650 (ChEBI)
Linoleic acid (LA) (18:2,w6)	Metabolite	17351 (ChEBI)	LA (18:2 w6)
Lipoxins Eoxins	Pathway
MAPK cascade	Metabolite
MCTR1	Metabolite
MCTR2	Metabolite
MCTR3	Metabolite
Maresin 1	Metabolite
Maresin 2	Metabolite
Membrane phospholipids	Metabolite	CHEBI:16247 (ChEBI)
Non-enzymatic
Non-enzymatic degradation
Non-enzymatic dehydration
Non-enzymatic,albumin-mediated degradation
Oncogene-induced senescence DNA damage-induced senescence Oxidative stress-induced senescence Replicative senescence Irradiation-induced senescence	Pathway
Osbond acid (22:5,w6)	Metabolite	CHEBI:65136 (ChEBI)	=docosapentaenoic acid (DPAω6, 22:5)
PAI-1	Protein	7 (Uniprot-TrEMBL)
PG-9KR	GeneProduct	ENSG00000159228 (Ensembl)	PG-9KR= Prostaglandin-9-ketoreductase
PGA Isomerase	GeneProduct
PGA1	Metabolite	14152-28-4 (CAS)
PGA2	Metabolite	27820 (ChEBI)	PGA2=Prostaglandin A2
PGB1	Metabolite	CHEBI:27624 (ChEBI)
PGB2	Metabolite	28099 (ChEBI)	PGB2=Prostaglandin B2
PGC Isomerase	GeneProduct
PGC1	Metabolite	CHEBI:15546 (ChEBI)
PGC2	Metabolite	27555 (ChEBI)	PGC2=Prostaglandin C2
PGD1	Metabolite	27696 (ChEBI)
PGD2	Metabolite	15555 (ChEBI)
PGD3	Metabolite	CHEBI:34939 (ChEBI)
PGDS	GeneProduct	EC 5.3.99.2 (Enzyme Nomenclature)
PGE 19-hydroxylase	GeneProduct
PGE1	Metabolite	15544 (ChEBI)
PGE2	Metabolite	15551 (ChEBI)
PGE3	Metabolite	CHEBI:28031 (ChEBI)
PGEM (11a-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid)	Metabolite	CHEBI:73965 (ChEBI)
PGES	GeneProduct	EC 5.3.99.3 (Enzyme Nomenclature)
PGF1a	Metabolite	28852 (ChEBI)
PGF3a	Metabolite	CHEBI:36075 (ChEBI)
PGFS	GeneProduct	EC 1.1.1.188 (Enzyme Nomenclature)	=Prostaglandin F synthase
PGG1	Metabolite	133739 (ChEBI)
PGG2	Metabolite	27647 (ChEBI)	Prostaglandin G2 is abbreviated as PGG2
PGG3	Metabolite	CHEBI:134406 (ChEBI)
PGH1	Metabolite	91133 (ChEBI)
PGH2	Metabolite	15554 (ChEBI)	PGH2 is the abbreviation of PGG2
PGH3	Metabolite	CHEBI:134407 (ChEBI)
PGI1*	Metabolite
PGI2	Metabolite	CHEBI:15552 (ChEBI)	Synonym for PGI2 is "Prostacyclin"
PGI3	Metabolite
PGIS	GeneProduct	EC 5.3.99.4 (Enzyme Nomenclature)
PGJ2	Metabolite	27485 (ChEBI)
PPARγ	Complex
PRAK/MAPKAPK5	Metabolite
PTGS1	GeneProduct	ENSG00000095303 (Ensembl)	=Prostaglandin-endoperoxide synthase 1 =cyclooxygenase (COX)
PTGS2	GeneProduct	ENSG00000073756 (Ensembl)	=prostaglandin-endoperoxide synthase 2 =cyclooxygenase (COX)
Phospholipase (cPLA2α)	GeneProduct
Prostaglandin F synthase
Prostaglandin [c]	Metabolite
Prostaglandin [e]	Metabolite
Protectins	Pathway
RAS	GeneProduct
RAS	GeneProduct	EC 3.6.5.2 (Enzyme Nomenclature)
RORalpha	Metabolite
ROS	Metabolite	26523 (ChEBI)
Radiation-induced senescence	Pathway
Rb	GeneProduct	ENSG00000139687 (Ensembl)
Rb	GeneProduct	j (Ensembl Human)
Replicative senescence Radiation-induced senescence	Pathway
SASP	Pathway
SASP	Pathway	WP3391 (WikiPathways)
SEH
SIRT1	GeneProduct	ENSG00000096717 (Ensembl)
SLCO2A1	GeneProduct	ENSG00000174640 (Ensembl)
Senescence phenotype	Pathway
Senescence	Pathway	WP615 (WikiPathways)
Spontaneous hydrolysis
Stearidonic acid (SDA) (18:4,w3)	Metabolite	CHEBI:32389 (ChEBI)
TBXAS1	GeneProduct	ENSG00000059377 (Ensembl)	=CYP5A1
TP	Complex		Beyond its primary agonist TXA2, the TP receptor is also available for its metabolic precursors prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2). Binding of both to TP showed similar platelet responses compared to TXA2
TXAS	GeneProduct	EC 5.3.99.5 (Enzyme Nomenclature)
TxA1*	Metabolite
TxA3	Metabolite
TxA	Metabolite	CHEBI:15627 (ChEBI)
TxB1	Metabolite	71668258 (PubChem-compound)
TxB	Metabolite	CHEBI:28728 (ChEBI)
Unknown
a-Linolenic acid (ALA) (18:3,w3)	Metabolite	CHEBI:27432 (ChEBI)	IUPAC Name: (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
alpha-tetranor-15-keto-13,14-dihydro-8-iso-PGF2a*	Metabolite
cAMP	Complex		PGI2 binding to the associated IP receptor (coupled to Gs) leads to an activation of the AC and thus to an increase of intracellular cAMP. Its elevation downregulates store-mediated calcium entry, calcium mobilization and secretion, as well as platelet adhesion to subendothelial collagen via integrin α2β1. The cAMP increase further results in an activation of protein kinase-A (PKA) and in principle, in an inhibition of platelet activation. Analogous to cAMP, PKA activity has been associated with a reduced Ca2+ release from intra-platelet stores
cPGES	GeneProduct	ENSG00000110958 (Ensembl)	=prostaglandin E synthase 3 (PGTES3)
elongation delta6 desaturation beta-oxidation
epoxide hydrolysis
mPGES-1	GeneProduct	ENSG00000148344 (Ensembl)	=microsomal prostaglandin E synthase 1 (PTGES1)
mPGES-2	GeneProduct	ENSG00000148334 (Ensembl)	=microsomal prostaglandin E synthase 2 (PTGES2)
p21	Protein	A0A024RCX5 (Uniprot-TrEMBL)
p38 MAPK	GeneProduct	ENSG00000185386 (Ensembl)
p53	GeneProduct
p53	Metabolite	CHEBI:77731 (ChEBI)
p53S37	Metabolite
w-hydroxylase*
y-linolenic acid (GLA) (18:3,w6)	Metabolite	28661 (ChEBI)	GLA(18:3 w6)
Δ12-PGD2	Metabolite
Δ12-PGJ2	Metabolite	CHEBI:28130 (ChEBI)	Synonym: 9-Deoxy-delta(9,12)-13,14-dihydro PGD2
Δ13-reductase	GeneProduct	EC 1.3.1.48 (Enzyme Nomenclature)	=15-oxoprostaglandin-Δ13-reductase
Δ6-trans-12-epi-leukotriene B4	Metabolite	CHEBI:63982 (ChEBI)
Δ9-Elongase*
β and ω oxidation*
β-oxidase*	GeneProduct
β-oxidation	Complex
β-oxidation*