Cigarette smoke induced lung fibrosis (Homo sapiens)

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Cigarette smoke exposureCollagen biosynthesisand modifying enzymesRelease ofpro-inflammatory mediatorsIncrease of ROSOxidative stress and ROSGrowth factor releaseLung epithelial cellsRegenerationandnormal lung functionOverview ofinflammatory mediatorsNF-kB pathwayFibrosisCollagen accumulationIncreased activation ofnuclear factor kappa B (NF-kB)


Description

Chronic cigarette smoke exposure induced lung fibrosis

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Quality Tags

Ontology Terms

 

Bibliography

  1. Makena P, Kikalova T, Prasad GL, Baxter SA; ''Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
  2. Estornut C, Milara J, Bayarri MA, Belhadj N, Cortijo J; ''Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis.''; Front Pharmacol, 2021 PubMed Europe PMC Scholia
  3. Ding R, Ren X, Sun Q, Sun Z, Duan J; ''An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework.''; J Adv Res, 2023 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135749view13:52, 8 November 2024EweitzModified title
135744view13:00, 6 November 2024Marvin M2added literature references and visual cleanup
135743view12:33, 6 November 2024Marvin M2added KE IDs
135742view12:26, 6 November 2024Marvin M2Ontology Term : 'pulmonary fibrosis' added !
129277view13:10, 17 March 2024BurritacoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Cigarette smoke exposure
Collagen accumulation68 (Other)
Collagen biosynthesis

and

modifying enzymes		PathwayWP2725 (WikiPathways)
Fibrosis1276 (Other)
Growth factor release
Increase of ROS
Increased activation

of nuclear factor kappa B

(NF-kB)		Complex1172 (Other)
Lung epithelial cells
NF-kB pathwayPathwayWP4562 (WikiPathways)
Overview of

inflammatory

mediators		PathwayWP5095 (WikiPathways)
Oxidative stress

and

ROS		PathwayWP554 (WikiPathways)
Regeneration

and

normal lung function
Release of

pro-inflammatory

mediators		1469 (Other)

Annotated Interactions

No annotated interactions

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