PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer (Homo sapiens)

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1mTORC2AKT inhibitorsATP site mTOR inhibitorsPI3K inhibitorsAllosteric mTOR inhibitorsPDK1S6K1AKTPIP3GSK3BeNOSRICTORFOXO3PTENMLST8TSC2ATG13p27PIP2FIP200RAPTORFOXO4TFEB4EBP1MTORMLST8BADRHEBMTORReceptor TyrosineKinasesULK1GRB10FOXO1PIK3CAPIK3CBPIK3R1PIK3R2PIK3R3PIK3CGG Protein-coupled ReceptorsHRASNRASKRASMAPKAP1mTORC1


Description

This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Merritt P Edlind, Andrew C Hsieh; ''PI3K-AKT-mTOR singaling in prostate cancer progression and androgen deprivation therapy resistance''; NIH, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129541view15:51, 10 May 2024EweitzModified title
129324view13:58, 26 March 2024MkutmonOntology Term : 'prostate cancer' added !
129323view13:58, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129322view13:58, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
127077view00:25, 28 July 2023Khanspersupdated mTORC1 and mTORC2 complexes
107714view08:20, 31 October 2019DeSlReverted to version '13:23, 17 September 2019' by DeSl
107700view11:37, 29 October 2019LilingModified description
106751view13:23, 17 September 2019MaintBotHMDB identifier normalization
106550view00:12, 6 September 2019KhanspersModified description
105495view05:49, 8 August 2019KhanspersModified description
89952view14:17, 6 October 2016MkutmonModified description
89754view18:10, 30 September 2016Khanspersupdated some interactions
89740view23:39, 29 September 2016KhanspersModified title
88432view20:17, 6 August 2016AlexanderPicoOntology Term : 'signaling pathway' added !
88431view20:14, 6 August 2016AlexanderPicoUpdated complex, metabolites and interactions
88430view19:34, 6 August 2016AlexanderPicoUpdated PMID
88369view21:15, 1 August 2016AAR&CoModified description
88367view21:13, 1 August 2016AAR&CoBolded Labels
88325view15:44, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
88323view15:43, 1 August 2016FehrhartOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
88213view17:36, 31 July 2016AAR&CoModify Datanode
88206view13:59, 31 July 2016AAR&CoPeriodical save, work in progress
88205view13:46, 31 July 2016AAR&CoModify Datanode
88200view12:55, 31 July 2016AAR&CoModify Datanode
88195view12:34, 31 July 2016AAR&CoClose excess space
87101view17:17, 18 July 2016AAR&CoFixed Unconnected Lines
86821view23:23, 11 July 2016AAR&CoModified description
86820view23:22, 11 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4EBP1 GeneProductENSG00000187840 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
FOXO4GeneProductENSG00000184481 (Ensembl)
G Protein-coupled ReceptorsGeneProduct
GRB10GeneProductENSG00000106070 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CGGeneProductENSG00000105851 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP2MetaboliteHMDB0010035 (HMDB)
PIP3MetaboliteHMDB0010147 (HMDB)
PTENGeneProductENSG00000171862 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
Receptor Tyrosine KinasesGeneProduct
S6K1GeneProductENSG00000082701 (Ensembl)
TFEBGeneProductENSG00000112561 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
eNOSGeneProductENSG00000164867 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

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