Monoamine transport (Homo sapiens)
From WikiPathways
Description
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
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- Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
- Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI; ''Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia
- Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
- Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD; ''Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
- Hahn MK, Robertson D, Blakely RD; ''A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.''; J Neurosci, 2003 PubMed Europe PMC Scholia
- Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR; ''Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex.''; J Neurosci, 2006 PubMed Europe PMC Scholia
- Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
- Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
- Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A; ''Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
- Iwamoto H, Blakely RD, De Felice LJ; ''Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.''; J Neurosci, 2006 PubMed Europe PMC Scholia
- Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
- Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD; ''A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.''; J Neurosci, 2003 PubMed Europe PMC Scholia
- Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
- Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
- Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S; ''Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
- Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD; ''Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
- Hahn MK, Blakely RD; ''Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia
- Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD; ''p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
- Miner LH, Schroeter S, Blakely RD, Sesack SR; ''Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals.''; J Comp Neurol, 2003 PubMed Europe PMC Scholia
- Dipace C, Sung U, Binda F, Blakely RD, Galli A; ''Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
- Savchenko V, Sung U, Blakely RD; ''Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody.''; Mol Cell Neurosci, 2003 PubMed Europe PMC Scholia
- Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
- Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
- Zhu CB, Blakely RD, Hewlett WA; ''The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.''; Neuropsychopharmacology, 2006 PubMed Europe PMC Scholia
- Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T; ''''; , PubMed Europe PMC Scholia
- Sung U, Blakely RD; ''Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A.''; Mol Cell Neurosci, 2007 PubMed Europe PMC Scholia
- Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD; ''Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
- Hahn MK, Blakely RD; ''The functional impact of SLC6 transporter genetic variation.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
- Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N; ''Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.''; Neuroscience, 2008 PubMed Europe PMC Scholia
- Steiner JA, Carneiro AM, Blakely RD; ''Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.''; Traffic, 2008 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
4-Aminobutanoic acid | Metabolite | 56-12-2 (CAS) | |
ACHE | GeneProduct | 43 (Entrez Gene) | acetylcholinesterase (Yt blood group) |
ADORA2A | GeneProduct | 135 (Entrez Gene) | adenosine A2a receptor |
AGT | GeneProduct | 183 (Entrez Gene) | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
AMPH | GeneProduct | 273 (Entrez Gene) | amphiphysin |
CDC25C | GeneProduct | 995 (Entrez Gene) | cell division cycle 25 homolog C (S. pombe) |
DBH | GeneProduct | 1621 (Entrez Gene) | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
FBXO32 | GeneProduct | 114907 (Entrez Gene) | F-box protein 32 |
HEPES | Metabolite | 7365-45-9 (CAS) | |
HRH3 | GeneProduct | 11255 (Entrez Gene) | histamine receptor H3 |
Hemicholinium-3 | Metabolite | 312-45-8 (CAS) | |
IL1B | GeneProduct | 3553 (Entrez Gene) | interleukin 1 beta |
IL1R1 | GeneProduct | 3554 (Entrez Gene) | interleukin 1 receptor, type I |
ITGB3 | GeneProduct | 3690 (Entrez Gene) | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
L-tryptophan | Metabolite | 73-22-3 (CAS) | |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | mitogen activated protein kinase 14 |
NOS1 | GeneProduct | 4842 (Entrez Gene) | nitric oxide synthase 1 (neuronal) |
PPP2CB | GeneProduct | 5516 (Entrez Gene) | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform |
PVRL2 | GeneProduct | 5819 (Entrez Gene) | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Phorbol ester | Metabolite | 16561-29-8 (CAS) | |
RBL2 | GeneProduct | 5934 (Entrez Gene) | retinoblastoma-like 2 (p130) |
SB 203580 | Metabolite | 152121-47-6 (CAS) | |
SCAMP2 | GeneProduct | 10066 (Entrez Gene) | secretory carrier membrane protein 2 |
SLC5A7 | GeneProduct | 60482 (Entrez Gene) | solute carrier family 5 (choline transporter), member 7 |
SLC6A1 | GeneProduct | 6529 (Entrez Gene) | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 |
SLC6A2 | GeneProduct | 6530 (Entrez Gene) | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 |
SLC6A3 | GeneProduct | 6531 (Entrez Gene) | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 |
SLC6A4 | GeneProduct | 6532 (Entrez Gene) | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
STX1A | GeneProduct | 6804 (Entrez Gene) | syntaxin 1A (brain) |
SYN1 | GeneProduct | 6853 (Entrez Gene) | synapsin I |
TDO2 | GeneProduct | 6999 (Entrez Gene) | tryptophan 2,3-dioxygenase |
TGFB1I1 | GeneProduct | 7041 (Entrez Gene) | transforming growth factor beta 1 induced transcript 1 |
TH | GeneProduct | 7054 (Entrez Gene) | tyrosine hydroxylase |
TNF | GeneProduct | 7124 (Entrez Gene) | tumor necrosis factor |
TNFRSF11B | GeneProduct | 4982 (Entrez Gene) | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) |
TPH2 | GeneProduct | 121278 (Entrez Gene) | tryptophan hydroxylase 2 |
TSC2 | GeneProduct | 7249 (Entrez Gene) | tuberous sclerosis 2 |
UNC13B | GeneProduct | 10497 (Entrez Gene) | unc-13 homolog B (C. elegans) |
anisomycin | Metabolite | CHEBI:338412 (ChEBI) | |
catecholamines | Metabolite | CHEBI:33567 (ChEBI) | |
citalopram | Metabolite | 59729-33-8 (CAS) | |
dopamine | Metabolite | 51-61-6 (CAS) | |
epinephrine | Metabolite | 51-43-4 (CAS) | |
noradrenaline | Metabolite | 51-41-2 (CAS) | |
reserpine | Metabolite | 50-55-5 (CAS) | |
serotonin | Metabolite | 50-67-9 (CAS) |
Annotated Interactions
No annotated interactions