2q13 copy number variation syndrome (Homo sapiens)

From WikiPathways

Revision as of 21:41, 22 July 2024 by Eweitz (Talk | contribs)
Jump to: navigation, search
Cell2020202020Extracelullar space1, 7301822, 25, 3883, 4515204752501520331944444, 27, 32, 43, 51163910, 14, 17, 37, 551520445423, 5315201515461541, 471244202339, 11, 28, 4024, 3634, 3513, 21, 26, 29, 483542EndosomePeroxisomeAGExtracellularExact function unknownExact function unknownIL36AARL14CSF2IL36RNIL23AZC3H8POLR1AIL36BIL2SLC20A1POLR1HPOLR2LCarboxyterminalpost-translationalmodifications of tubulinSTAT1SLC20A1IL36GMIR4435-2PLCG2ANAPC1Canonical NF-kB pathwayNa+extracellular matrixIL37IL1F10IL1RNPOLR1BFADIL1RAPMitochondrialprotein importTTLACOXLimmunomodulationdendritic cellMERTKRN7SL297PPiPeroxisomal lipid metabolismMIR4771-1HMGN2P23RAC1MAPK cascadeAnti-inflammatorycytokinesRPS14P4CHCHD5mitotic spindleassemblyCXCL13IL1ASOCS3IL6ZC3H6POLR2KmacrophageIL1RAPtranscription elongation factor complexPOLR1DPOLR2EApoptosisinnate immune responseMAPK1CKAP2LPOLR1FGRB2actin cytoskeleton reorganization GDPPOLR1GPOLR1BARF6SOCS1RNU6-1180PMIR4771-2RGPD8CSF1microtubuleodontoblastIL1RL2PSD4TULP1ACOXLRegulation of mitotic cell cycleIL1BLGALS3Epithelial inflammatory responseTMEM87BPOLR2FPOLR2HGATA3RNA pol I holoenzymePOLR1CNT5DC4snRNA transcription by RNA polymerase IIproteinsIL36RNPTK2APC/C complexMIR4435-1HGTeeth developmentIL1R1POLR1ERPL5P9immature T cellproliferation in thymusIL-1 signaling pathwayBCL2L11MIR4435-1RNA Polymerase I TranscriptionGAS6FBLN7PTK2MAPK1RAC133Na+Pi444444444444443156B cell proliferation49ARF6ARL14proteinschr2:111,490,150chr2:96,097,38371GTPGDPGDPGTPGTP13, 21, 26, 29, 48FILIPPI SYNDROME; FLPISLegendTranslocationStimulation of enzyme or gene leading to its activation or expressionMicroRNA or other RNA genePathwayInhibition of function or processCatalysis of compound by enzymeTranscription-translation of geneMetaboliteUnclear interaction mechanism orunclear intermediatesGene or gene productConversionBindingPseudogenePhosphorylated proteinComplexAssociated neuropathology


Description

The 2q13 copy number variation syndrome can result in the loss of up to 25 protein-coding genes. Patients with 2q13 deletions and duplications had abnormal head size and dysmorphic features (DOI: 10.1002/ajmg.a.37269). 2q13 duplications also caused developmental delay. The abnormal head size in 2q13 could be explained by the changes in FBLN7 gene (DOI: 10.1002/ajmg.a.37269). At the same time, neuropsychiatric impairment in 2q13 may be associated with BCL2L11, ANAPC1, SLC1A1 and MERTK alterations (DOI: 10.1002/ajmg.b.32236).

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Chang LF, Zhang Z, Yang J, McLaughlin SH, Barford D; ''Molecular architecture and mechanism of the anaphase-promoting complex.''; Nature, 2014 PubMed Europe PMC Scholia
  2. Chen J, Carey K, Godowski PJ; ''Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.''; Oncogene, 1997 PubMed Europe PMC Scholia
  3. Vanhove GF, Van Veldhoven PP, Fransen M, Denis S, Eyssen HJ, Wanders RJ, Mannaerts GP; ''The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acidsare oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  4. Spolski R, Li P, Leonard WJ; ''''; , PubMed Europe PMC Scholia
  5. Baumgart E, Vanhooren JC, Fransen M, Marynen P, Puype M, Vandekerckhove J, Leunissen JA, Fahimi HD, Mannaerts GP, van Veldhoven PP; ''Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC Scholia
  6. Lennard AC; ''lnterleukin-1 Receptor Antagonist.''; Crit Rev Immunol, 2017 PubMed Europe PMC Scholia
  7. Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H; ''Mitosis. Microtubule detyrosination guides chromosomes during mitosis.''; Science, 2015 PubMed Europe PMC Scholia
  8. Hannan RD, Hempel WM, Cavanaugh A, Arino T, Dimitrov SI, Moss T, Rothblum L; ''Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  9. Lemke G, Rothlin CV; ''Immunobiology of the TAM receptors.''; Nat Rev Immunol, 2008 PubMed Europe PMC Scholia
  10. Wen L, Liang DS, Wu LQ, Cai F, Pan Q, Long ZG, Dai HP, Xia K, Xia JH; ''Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.''; Biochem Biophys Res Commun, 2008 PubMed Europe PMC Scholia
  11. Zhou L, Todorovic V; ''Interleukin-36: Structure, Signaling and Function.''; Adv Exp Med Biol, 2021 PubMed Europe PMC Scholia
  12. Hussain MS, Battaglia A, Szczepanski S, Kaygusuz E, Toliat MR, Sakakibara S, Altmüller J, Thiele H, Nürnberg G, Moosa S, Yigit G, Beleggia F, Tinschert S, Clayton-Smith J, Vasudevan P, Urquhart JE, Donnai D, Fryer A, Percin F, Brancati F, Dobbie A, Smigiel R, Gillessen-Kaesbach G, Wollnik B, Noegel AA, Newman WG, Nürnberg P; ''Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome.''; Am J Hum Genet, 2014 PubMed Europe PMC Scholia
  13. Comai L; ''Mechanism of RNA polymerase I transcription.''; Adv Protein Chem, 2004 PubMed Europe PMC Scholia
  14. Ni Z, Xu C, Guo X, Hunter GO, Kuznetsova OV, Tempel W, Marcon E, Zhong G, Guo H, Kuo WW, Li J, Young P, Olsen JB, Wan C, Loppnau P, El Bakkouri M, Senisterra GA, He H, Huang H, Sidhu SS, Emili A, Murphy S, Mosley AL, Arrowsmith CH, Min J, Greenblatt JF; ''RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.''; Nat Struct Mol Biol, 2014 PubMed Europe PMC Scholia
  15. Jackson TR, Kearns BG, Theibert AB; ''Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.''; Trends Biochem Sci, 2000 PubMed Europe PMC Scholia
  16. Bøttger P, Pedersen L; ''Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.''; BMC Biochem, 2011 PubMed Europe PMC Scholia
  17. Yumoto T, Nakadate K, Nakamura Y, Sugitani Y, Sugitani-Yoshida R, Ueda S, Sakakibara S; ''Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors.''; PLoS One, 2013 PubMed Europe PMC Scholia
  18. Bøttger P, Hede SE, Grunnet M, Høyer B, Klaerke DA, Pedersen L; ''Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.''; Am J Physiol Cell Physiol, 2006 PubMed Europe PMC Scholia
  19. Hwang ES, Choi A, Ho IC; ''Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1.''; J Immunol, 2002 PubMed Europe PMC Scholia
  20. Esmaeilzadeh A, Bahmaie N, Nouri E, Hajkazemi MJ, Zareh Rafie M; ''Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
  21. Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R; ''Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.''; Cell, 2005 PubMed Europe PMC Scholia
  22. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR; ''Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia
  23. Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi H, Takahashi T, Kage M, Kuwano M, Ono M; ''Tumor-derived interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages.''; PLoS One, 2014 PubMed Europe PMC Scholia
  24. Hannan RD, Cavanaugh A, Hempel WM, Moss T, Rothblum L; ''Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system.''; Nucleic Acids Res, 1999 PubMed Europe PMC Scholia
  25. Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J; ''Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.''; J Cell Biol, 2002 PubMed Europe PMC Scholia
  26. O'Reilly D, Kuznetsova OV, Laitem C, Zaborowska J, Dienstbier M, Murphy S; ''Human snRNA genes use polyadenylation factors to promote efficient transcription termination.''; Nucleic Acids Res, 2014 PubMed Europe PMC Scholia
  27. Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J; ''FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  28. Jin L, Williamson A, Banerjee S, Philipp I, Rape M; ''Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.''; Cell, 2008 PubMed Europe PMC Scholia
  29. Hirata T, Fujita M, Nakamura S, Gotoh K, Motooka D, Murakami Y, Maeda Y, Kinoshita T; ''''; , PubMed Europe PMC Scholia
  30. Beck L, Leroy C, Salaün C, Margall-Ducos G, Desdouets C, Friedlander G; ''Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  31. Mouhamad S, Besnault L, Auffredou MT, Leprince C, Bourgeade MF, Leca G, Vazquez A; ''B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.''; J Immunol, 2004 PubMed Europe PMC Scholia
  32. Caberoy NB, Zhou Y, Li W; ''Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.''; EMBO J, 2010 PubMed Europe PMC Scholia
  33. U M, Miyashita T, Shikama Y, Tadokoro K, Yamada M; ''Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family.''; FEBS Lett, 2001 PubMed Europe PMC Scholia
  34. Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P; ''Structure of the initiation-competent RNA polymerase I and its implication for transcription.''; Nat Commun, 2016 PubMed Europe PMC Scholia
  35. Jia H, Liu J, Han B; ''Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.''; Biomed Res Int, 2018 PubMed Europe PMC Scholia
  36. Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, Houlgatte R, Chavrier P; ''A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
  37. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H; ''An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.''; J Proteomics, 2014 PubMed Europe PMC Scholia
  38. Seither P, Grummt I; ''Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I.''; Genomics, 1996 PubMed Europe PMC Scholia
  39. Hofmann S, Rothbauer U, Mühlenbein N, Baiker K, Hell K, Bauer MF; ''Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space.''; J Mol Biol, 2005 PubMed Europe PMC Scholia
  40. O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC; ''Bim: a novel member of the Bcl-2 family that promotes apoptosis.''; EMBO J, 1998 PubMed Europe PMC Scholia
  41. Spolski R, Li P, Leonard WJ; ''Biology and regulation of IL-2: from molecular mechanisms to human therapy.''; Nat Rev Immunol, 2018 PubMed Europe PMC Scholia
  42. Tominaga K, Yoshimoto T, Torigoe K, Kurimoto M, Matsui K, Hada T, Okamura H, Nakanishi K; ''IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.''; Int Immunol, 2000 PubMed Europe PMC Scholia
  43. Riley KN, Catalano LM, Bernat JA, Adams SD, Martin DM, Lalani SR, Patel A, Burnside RD, Innis JW, Rudd MK; ''Recurrent deletions and duplications of chromosome 2q11.2 and 2q13 are associated with variable outcomes.''; Am J Med Genet A, 2015 PubMed Europe PMC Scholia
  44. Panov KI, Panova TB, Gadal O, Nishiyama K, Saito T, Russell J, Zomerdijk JC; ''RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor.''; Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  45. Chakraborty P, Dash SP, Sarangi PP; ''The role of adhesion protein Fibulin7 in development and diseases.''; Mol Med, 2020 PubMed Europe PMC Scholia
  46. Hu D, Smith ER, Garruss AS, Mohaghegh N, Varberg JM, Lin C, Jackson J, Gao X, Saraf A, Florens L, Washburn MP, Eissenberg JC, Shilatifard A; ''The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.''; Mol Cell, 2013 PubMed Europe PMC Scholia
  47. Geley S, Kramer E, Gieffers C, Gannon J, Peters JM, Hunt T; ''Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.''; J Cell Biol, 2001 PubMed Europe PMC Scholia
  48. Sims JE, Smith DE; ''The IL-1 family: regulators of immunity.''; Nat Rev Immunol, 2010 PubMed Europe PMC Scholia
  49. Chen JZ, Ji CN, Gu SH, Li JX, Zhao EP, Huang Y, Huang L, Ying K, Xie Y, Mao YM; ''Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis.''; Int J Biochem Cell Biol, 2004 PubMed Europe PMC Scholia
  50. Caberoy NB, Alvarado G, Bigcas JL, Li W; ''Galectin-3 is a new MerTK-specific eat-me signal.''; J Cell Physiol, 2012 PubMed Europe PMC Scholia
  51. Costain G, Lionel AC, Fu F, Stavropoulos DJ, Gazzellone MJ, Marshall CR, Scherer SW, Bassett AS; ''Adult neuropsychiatric expression and familial segregation of 2q13 duplications.''; Am J Med Genet B Neuropsychiatr Genet, 2014 PubMed Europe PMC Scholia
  52. Hafizi S, Dahlbäck B; ''Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.''; Cytokine Growth Factor Rev, 2006 PubMed Europe PMC Scholia
  53. Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R; ''Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.''; Arthritis Rheum, 2005 PubMed Europe PMC Scholia
  54. Fernandes I, Béliveau R, Friedlander G, Silve C; ''NaPO(4) cotransport type III (PiT1) expression in human embryonic kidney cells and regulation by PTH.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
  55. Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO; ''Structural basis of tubulin tyrosination by tubulin tyrosine ligase.''; J Cell Biol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134652view09:14, 24 July 2024EgonwAdded the missing OMIM data source for a given identifier
134549view21:47, 22 July 2024EweitzAdd missing database names
134548view21:41, 22 July 2024EweitzOntology Term : 'chromosomal duplication syndrome' added !
134547view21:40, 22 July 2024EweitzOntology Term : 'chromosomal deletion syndrome' added !
134546view21:39, 22 July 2024EweitzRefine legend
122737view12:50, 7 May 2022Shad4Added neuropathologies
122625view09:51, 22 April 2022Shad4Modified description
122601view18:22, 20 April 2022Shad4Converted labels into processes without id and database
122598view12:37, 20 April 2022FehrhartOntology Term : 'disease pathway' added !
122551view11:28, 15 April 2022Shad4New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACOXLProteinENSG00000153093 (Ensembl)
ANAPC1GeneProductENSG00000153107 (Ensembl)
APC/C complexComplexCPX-1860
ARF6ProteinENSG00000165527 (Ensembl)
ARL14ProteinENSG00000179674 (Ensembl)
Anti-inflammatory cytokines
ApoptosisPathwayWP254 (WikiPathways)
B cell proliferationQ14863410 (Wikidata)
BCL2L11GeneProductENSG00000153094 (Ensembl)
CHCHD5GeneProductENSG00000125611 (Ensembl)
CKAP2LGeneProductENSG00000169607 (Ensembl)
CSF1ProteinENSG00000184371 (Ensembl)
CSF2ProteinENSG00000164400 (Ensembl)
CXCL13ProteinENSG00000156234 (Ensembl)
Canonical NF-kB pathwayPathwayWP4562 (WikiPathways)
Carboxyterminal

post-translational

modifications of tubulin		PathwayWP4075 (WikiPathways)
GeneProduct
Epithelial inflammatory response
FADMetaboliteCHEBI:57692 (ChEBI)
FBLN7GeneProductENSG00000144152 (Ensembl)
FILIPPI SYNDROME; FLPIS272440
GAS6ProteinENSG00000183087 (Ensembl)
GATA3ProteinENSG00000107485 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinENSG00000177885 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
HMGN2P23GeneProductENSG00000236124 (Ensembl)
IL-1 signaling pathwayPathwayWP195 (WikiPathways)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1F10GeneProductENSG00000136697 (Ensembl)
IL1R1ProteinENSG00000115594 (Ensembl)
IL1RAPProteinENSG00000196083 (Ensembl)
IL1RL2ProteinENSG00000115598 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IL23AProteinENSG00000110944 (Ensembl)
IL2ProteinENSG00000109471 (Ensembl)
IL36AGeneProductENSG00000136694 (Ensembl)
IL36BGeneProductENSG00000136696 (Ensembl)
IL36GGeneProductENSG00000136688 (Ensembl)
IL36RNGeneProductENSG00000136695 (Ensembl)
IL37GeneProductENSG00000125571 (Ensembl)
IL6ProteinENSG00000136244 (Ensembl)
LGALS3ProteinENSG00000131981 (Ensembl)
MAPK cascadePathwayWP422 (WikiPathways)
MAPK1ProteinENSG00000100030 (Ensembl)
MERTKGeneProductENSG00000153208 (Ensembl)
MIR4435-1GeneProductENSG00000266139 (Ensembl)
MIR4435-1HGGeneProductENSG00000172965 (Ensembl)
MIR4435-2GeneProductENSG00000266139 (Ensembl)
MIR4771-1GeneProductENSG00000266063 (Ensembl)
MIR4771-2GeneProductENSG00000266063 (Ensembl)
Mitochondrial protein importPathwayWP2717 (WikiPathways)
NT5DC4GeneProductENSG00000144130 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PLCG2GeneProductENSG00000197943 (Ensembl)
POLR1AGeneProductENSG00000068654 (Ensembl)
POLR1BGeneProductENSG00000125630 (Ensembl)
POLR1CGeneProductENSG00000171453 (Ensembl)
POLR1DGeneProductENSG00000186184 (Ensembl)
POLR1EGeneProductENSG00000137054 (Ensembl)
POLR1FGeneProductENSG00000105849 (Ensembl)
POLR1GGeneProductENSG00000117877 (Ensembl)
POLR1HGeneProductENSG00000066379 (Ensembl)
POLR2EGeneProductENSG00000099817 (Ensembl)
POLR2FGeneProductENSG00000100142 (Ensembl)
POLR2HGeneProductENSG00000163882 (Ensembl)
POLR2KGeneProductENSG00000147669 (Ensembl)
POLR2LGeneProductENSG00000177700 (Ensembl)
PSD4GeneProductENSG00000125637 (Ensembl)
PTK2ProteinENSG00000169398 (Ensembl)
Peroxisomal lipid metabolismPathwayWP1878 (WikiPathways)
PiMetaboliteCHEBI:43474 (ChEBI)
RAC1ProteinENSG00000136238 (Ensembl)
RGPD8GeneProductENSG00000169629 (Ensembl)
RN7SL297PGeneProductENSG00000240183 (Ensembl)
RNA Polymerase I TranscriptionPathwayWP4074 (WikiPathways)
RNA pol I holoenzymeComplex
RNU6-1180PGeneProductENSG00000201805 (Ensembl)
RPL5P9GeneProductENSG00000236330 (Ensembl)
RPS14P4GeneProductENSG00000226928 (Ensembl)
Regulation of mitotic cell cyclePathwayWP4109 (WikiPathways)
SLC20A1GeneProductENSG00000144136 (Ensembl)
SOCS1ProteinENSG00000185338 (Ensembl)
SOCS3ProteinENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
TMEM87BGeneProductENSG00000153214 (Ensembl)
TTLGeneProductENSG00000114999 (Ensembl)
TULP1ProteinENSG00000112041 (Ensembl)
Teeth development
ZC3H6GeneProductENSG00000188177 (Ensembl)
ZC3H8GeneProductENSG00000144161 (Ensembl)
actin cytoskeleton reorganization Q14908027 (Wikidata)
dendritic cellQ506253 (Wikidata)
extracellular matrixQ193825 (Wikidata)
immature T cell proliferation in thymusQ15321801 (Wikidata)
immunomodulationQ27788458 (Wikidata)
innate immune responseQ428253 (Wikidata)
macrophageQ184204 (Wikidata)
microtubuleQ189933 (Wikidata)
mitotic spindle assemblyQ14912279 (Wikidata)
odontoblastQ853338 (Wikidata)
proteinsMetaboliteCHEBI:36080 (ChEBI)
snRNA transcription by RNA polymerase IIQ21114367 (Wikidata)
transcription elongation factor complexComplexQ15314914 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5222"
Personal tools