Hepatocyte growth factor receptor signaling (Pan troglodytes)
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RHO
pathway
P
RAC1
pathway
Changes in Cytoskeleton
and Cell mobility
Anoikis
P
Transcription
of Cox2
Cytoplasm
Extracellular
AKT Pathway
Right Click for Comments
AP-1
Trancription
Transcription
CDC42
pathway
P
Actin
MAP2K1
ELK1
DOCK1
PTK2B
PTK2B
STAT3
SOS1
RAP1A
RASA1
SRC
MAP2K2
MAPK1
RAPGEF1
HGF
CRK
ITGB1
PAK1
MAP4K1
HRAS
MAPK3
PTPN11
PXN
GAB1
PIK3CA
MAPK8
PTK2
Met
SRC
RAP1B
GRB2
PTEN
FOS
JUN
RAF1
PXN
ITGA1
CRKL
PTK2
Description
No description
Comments
GenMAPP remarks
Converted to human by GenMAPP.org
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP313(r21339)
with a 86% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
118823
view
08:55, 2 June 2021
DeSl
Ontology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118821
view
08:06, 2 June 2021
DeSl
Ontology Term : 'hepatocyte' added !
118820
view
08:05, 2 June 2021
DeSl
Converted "P" to States
118819
view
08:04, 2 June 2021
DeSl
Converted ReceptorSquare to MIM binding with lit ref
118818
view
08:02, 2 June 2021
DeSl
Converted unconnected lines to Graphical lines
118817
view
08:02, 2 June 2021
DeSl
Deleted textLabel
118816
view
08:01, 2 June 2021
DeSl
Added description from WP313
118037
view
11:49, 23 May 2021
Eweitz
Modified title
87670
view
08:55, 25 July 2016
Lindarieswijk
Ontology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
69306
view
18:42, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41616
view
02:02, 2 March 2011
MaintBot
Removed redundant pathway information and comments
34344
view
22:19, 9 December 2009
MaintBot
Automatic update of empty xrefs
33580
view
09:49, 1 December 2009
MaintBot
Removed group label
31604
view
22:10, 13 August 2009
MaintBot
Fixed text labels
30496
view
21:40, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CRK
GeneProduct
747142 (Entrez Gene)
CRKL
GeneProduct
470146 (Entrez Gene)
DOCK1
GeneProduct
Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1
GeneProduct
FOS
GeneProduct
453047 (Entrez Gene)
GAB1
GeneProduct
461516 (Entrez Gene)
GRB2
GeneProduct
737245 (Entrez Gene)
HGF
GeneProduct
463503 (Entrez Gene)
HRAS
GeneProduct
466302 (Entrez Gene)
ITGA1
GeneProduct
461880 (Entrez Gene)
ITGB1
GeneProduct
450396 (Entrez Gene)
JUN
GeneProduct
456893 (Entrez Gene)
MAP2K1
GeneProduct
450188 (Entrez Gene)
MAP2K2
GeneProduct
456390 (Entrez Gene)
MAP4K1
GeneProduct
MAPK1
GeneProduct
458680 (Entrez Gene)
MAPK3
GeneProduct
454037 (Entrez Gene)
MAPK8
GeneProduct
450445 (Entrez Gene)
Met
GeneProduct
PAK1
GeneProduct
451439 (Entrez Gene)
PIK3CA
GeneProduct
460858 (Entrez Gene)
PTEN
GeneProduct
466142 (Entrez Gene)
PTK2
GeneProduct
464422 (Entrez Gene)
PTK2B
GeneProduct
464073 (Entrez Gene)
PTPN11
GeneProduct
PXN
GeneProduct
452303 (Entrez Gene)
RAF1
GeneProduct
460182 (Entrez Gene)
RAP1A
GeneProduct
469408 (Entrez Gene)
RAP1B
GeneProduct
452065 (Entrez Gene)
RAPGEF1
GeneProduct
464812 (Entrez Gene)
RASA1
GeneProduct
461762 (Entrez Gene)
SOS1
GeneProduct
459171 (Entrez Gene)
Son of sevenless homolog 1 (Drosophila) (predicted)
SRC
GeneProduct
458229 (Entrez Gene)
STAT3
GeneProduct
454682 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Discussion
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DataNodes
Annotated Interactions
No annotated interactions