DNA replication (Mus musculus)

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1-3Mcm3Orc complexMcm7Mcm5Mcm4Degraded byproteasomein cytosolRNA primer-DNA primer:origin duplex:PCNACdt1Mcm75. Leading/lagging strand synthesisp58GemininOrc2Cdc6RFC140Orc complexOrc5Orc1Mcm33. DNA replication initiationp70PrimaseOrc2Cdc6p180DNA polymerase alpha:primase: origin complexMcm4Pre-replicative complexOrc complexRFC36RNA primer-DNA primerOrc2Processive complexMcm6Ubiquitinated Orc1RNA primer-DNA primer1. Assembly of the pre-replicative complexMcm6Phosphorylated Cdc6UbiquitinCdt1DNAPolymerase AOrc4Mcm5OriginRNA PrimerMcm 4,6,7 trimer forms andassociates with the replication forkMcm2Orc4Degraded by proteasome in cytosolPre-replicative complexOrc3Mcm2Phosphorylation ofMcm 2-7 complexMcm10Orc complexRFC Heteropentamer:RNA primer-DNA primerRFC40Orc3Cdc6Orc3DNA polymerase alpha:primase: origin complexOrc3RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerPhosphorylated Orc1UbiquitinCdt1Orc complex4. Switching of origins to post-replicative stateCdt1Ubiquitinated Cdc6Mcm10RFC37p49Cdt1RFC38Orc52. Activation of the pre-replicative complexCdc6Orc5Orc2Mcm6Pole2Orc3lCdc6RPA4Mcm7CTPPrim2Cdk2Rpa3dUTPDbf4ATPCdt1Orc6lRpa2Orc2lMcm2Prim1ATPGTPMcm3dCTPUbcPold2Rfc4Orc4lATPdGTPMcm4Uba52ADPRfc1ATPADPOrc5lPold1Cdc45lMcm10dATPPold4Rfc3PcnaMcm5Rpa1Cdc7GmnnPold3Pola1Rfc5Rfc2Pola2UTPPoleOrc1l


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117872view10:19, 23 May 2021EweitzModified title
107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATPMetaboliteHMDB01532 (HMDB)
CTPMetaboliteHMDB00998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB01440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetabolite17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB01532 (HMDB)
dCTPMetaboliteHMDB00998 (HMDB)
dGTPMetaboliteHMDB01440 (HMDB)
dUTPMetabolite17625 (ChEBI)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP150"
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