Irinotecan pathway (Mus musculus)

From WikiPathways

Revision as of 13:09, 12 February 2010 by Thomas (Talk | contribs)
Jump to: navigation, search
1, 2IntestineLiver CellNeutropeniaModel human liver cell showing blood, bile and intestinal compartments, indicating tissueinvolvment of genes in the irinotecan pathway.DiarrheaAbcg2NPCGm5744CYP3A5Ugt1a9Abcc1M4CYP3A4IrinotecanAbcc2Abcc1SN-38ApcCYP3A4Ces3SN-38Ugt1a6SN-38Ugt1a1CYP3A4CYP3A5Abcc1SN-38GBcheUgt1a6SN-38Abcc2Gm5744Ugt1a10Ces3IrinotecanUgt1a1IrinotecanCes3Gm5744Gm5744Abcc2Ces3


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP229(r26589) with a 51% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Desai AA, Innocenti F, Ratain MJ; ''UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.''; Pharmacogenetics, 2003 PubMed Europe PMC Scholia
  2. Mathijssen RH, Marsh S, Karlsson MO, Xie R, Baker SD, Verweij J, Sparreboom A, McLeod HL; ''Irinotecan pathway genotype analysis to predict pharmacokinetics.''; Clin Cancer Res, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116618view10:13, 9 May 2021EweitzOntology Term : 'cancer' added !
116617view10:13, 9 May 2021EweitzOntology Term : 'neutropenia' added !
116616view10:12, 9 May 2021EweitzOntology Term : 'diarrhea' added !
116609view09:42, 9 May 2021EweitzModified title
93210view18:51, 3 August 2017AlexanderPicoAdded ChEBI ID for APC metabolite
93198view15:52, 2 August 2017DeSlChanged several gene nodes to metabolite nodes, added IDs for them.
69144view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67411view10:58, 26 June 2013DdiglesOntology Term : 'irinotecan drug pathway' added !
48258view21:54, 17 May 2012KhanspersUpdating PubChem xrefs
41333view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35498view13:09, 12 February 2010ThomasModified description
35495view13:09, 12 February 2010Thomasadded literature, removed genmapp comment
32970view23:35, 28 September 2009MaintBotadded xrefs
32443view17:18, 15 August 2009MaintBotFixed text labels
32116view13:50, 14 August 2009MaintBotFixed group labels
31460view21:15, 13 August 2009MaintBotFixed text labels
30911view00:27, 30 July 2009MaintBotConverted from Homo sapiens
21680view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Irinotecan pathway PharmGKB]] moved to [[Pathway:WP475]]: Moved to stable identifier
8226view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Irinotecan pathway PharmGKB]] moved to [[Pathway:Mus musculus:Irinotecan pathway PharmGKB]]: Renaming species
7733view16:14, 18 December 2007MaintBotfixed category names
7480view12:42, 4 November 2007MaintBotAdded categories to GPML
6470view22:19, 22 May 2007169.230.77.174gpml file for [[Mouse:Irinotecan_pathway_PharmGKB]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abcc1GeneProduct17250 (Entrez Gene)
Abcc2GeneProduct12780 (Entrez Gene)
Abcg2GeneProduct26357 (Entrez Gene)
ApcGeneProduct11789 (Entrez Gene)
BcheGeneProduct12038 (Entrez Gene)
CYP3A4GeneProduct
CYP3A5GeneProduct
Ces3GeneProduct104158 (Entrez Gene)
Gm5744GeneProduct436059 (Entrez Gene)
IrinotecanMetabolite3750 (PubChem)
M4GeneProduct
NPCGeneProduct
SN-38GeneProduct
SN-38GGeneProduct
Ugt1a10GeneProduct394430 (Entrez Gene)
Ugt1a1GeneProduct394436 (Entrez Gene)
Ugt1a6GeneProduct94284 (Entrez Gene)
Ugt1a9GeneProduct394434 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP475"
Personal tools