Irinotecan pathway (Canis familiaris)

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1, 2Model human liver cell showing blood, bile and intestinal compartments, indicating tissueinvolvment of genes in the irinotecan pathway.IntestineDiarrheaLiver CellNeutropeniaIrinotecanM4CES1CES1ABCC1SN-38GCES2ABCC2UGT1A9SN-38CES1APCCYP3A5UGT1A1SN-38ABCC2ABCG2SN-38UGT1A1CYP3A4CES2ABCC1ABCC1IrinotecanIrinotecanBCHECYP3A4CYP3A4SN-38CES2CYP3A5UGT1A10CES2ABCC2UGT1A6UGT1A6NPCCES1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP229(r26589) with a 51% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Desai AA, Innocenti F, Ratain MJ; ''UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.''; Pharmacogenetics, 2003 PubMed Europe PMC Scholia
  2. Mathijssen RH, Marsh S, Karlsson MO, Xie R, Baker SD, Verweij J, Sparreboom A, McLeod HL; ''Irinotecan pathway genotype analysis to predict pharmacokinetics.''; Clin Cancer Res, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116615view09:59, 9 May 2021EweitzModified description
116610view09:42, 9 May 2021EweitzModified title
93222view17:39, 4 August 2017AlexanderPicoAdded ChEBI ID for APC metabolite
93197view15:47, 2 August 2017DeSlChanged several gene nodes to metabolite nodes, added IDs for them.
68768view16:03, 7 July 2013EgonwChanged the PubChem compound ID of irinotecan, following the discussion of WP961 -> http://wikipathways.org/index.php/Thread:PubChem_ID_for_irinotecan_should_be_verified_%281%29
68608view23:33, 5 July 2013MaintBotUpdated to 2013 gpml schema
67408view10:57, 26 June 2013DdiglesOntology Term : 'irinotecan drug pathway' added !
40768view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35505view13:15, 12 February 2010ThomasModified description
35504view13:14, 12 February 2010Thomasadded literature, removed genmapp comments
34037view18:50, 9 December 2009MaintBotAutomatic update of empty xrefs
32273view13:05, 15 August 2009MaintBotFixed text labels
31807view12:20, 14 August 2009MaintBotFixed group labels
31301view20:11, 13 August 2009MaintBotFixed text labels
30766view23:14, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC1GeneProduct403453 (Entrez Gene)
ABCC2GeneProduct403632 (Entrez Gene)
ABCG2GeneProduct478472 (Entrez Gene)
APCGeneProduct479139 (Entrez Gene)
BCHEGeneProduct488143 (Entrez Gene)
CES1GeneProduct403643 (Entrez Gene)
CES2GeneProduct489769 (Entrez Gene)
CYP3A4GeneProduct
CYP3A5GeneProduct
IrinotecanMetabolite3750 (PubChem)
M4GeneProduct
NPCGeneProduct
SN-38GeneProduct
SN-38GGeneProduct
UGT1A1GeneProduct
UGT1A10GeneProduct
UGT1A6GeneProduct403629 (Entrez Gene)
UGT1A9GeneProduct

Annotated Interactions

No annotated interactions
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