G1 to S cell cycle control (Homo sapiens)

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1pG1 CyclinDependant CyclasespCell cycle DNA replication genesbDNA replicationucakG1/S Cell CycleCyclin Esinactivedp1TTTCC/GCGCebCyclin DspG1/S transition CyclinDependent KinasesE2fpueDNA polymerasesG1/S transition Phasephosphorylation of proteinsinvolved in G1/S transitionppDegradationG2 Phase-M phaseuRborigin recognition complexG1 PhaseCheckpointCCNE1CDC2ACCNG2MCM7CdkCREB1MCM3CCNB1ORC3LE2fCDK7CCNE1ORC6LORC1LMYT1CDKN2CCDKN1CORC5LCDK4POLECDC45LTP53CCNA1POLA2POLE2MCM2E2fCDKN2APCNACDC2AE2F2MCM5CREB3L3ORC2LTFDP2TFDP1CDKN2DCREBL1MCM6TP53RPA3E2F3E2F1CDKN2BMCM4CDK4CDK6CDKN1BCDC25APRIM1CREB3ORC4LCDK2CCNE1CCND3E2F5CCNHWEE1CDKRB1CDKN1ACDK6CyclinDCyclinDCREB3L1MDM2E2F6E2F4CDK7RB1CCNE2RB1PRIM2ACDKRBL1CCND1CCND2TFDP1MNAT1ATMRPA2GADD45AMYCRPA1CdkCREB3L4


Description

No description

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134854view19:51, 27 July 2024EweitzEconomize layout
134853view19:50, 27 July 2024EweitzEconomize layout
128014view15:59, 21 January 2024EweitzFix typo (dependant cyclase -> dependent kinase), standardize case
127353view18:38, 20 September 2023Khanspersupdated phospho sites
127256view18:17, 28 August 2023Khanspersadded literature reference and updated description
123406view06:47, 23 July 2022EgonwMade a pathway clickable
106424view22:02, 28 August 2019KhanspersModified description
105450view05:01, 8 August 2019KhanspersModified description
105449view04:59, 8 August 2019KhanspersModified description
105242view22:50, 23 July 2019Khansperswork in progress
105241view22:45, 23 July 2019Khansperswork in progress
105240view22:40, 23 July 2019Khansperswork in progress
105239view20:54, 23 July 2019KhanspersUpdated layout
102300view20:48, 17 December 2018Khanspersremoved GenMAPP comment
97000view22:11, 25 April 2018Khanspersadded phosphosites, general cleanup
95145view03:02, 17 November 2017AlexanderPicoconnected interactions
95124view15:09, 16 November 2017DeSlFixed nested groups
94764view16:01, 5 October 2017Ryanmillerconnected lines
80001view08:36, 30 April 2015Zarichanged Box for CyclinD an CdK , annotated CDC2A gene
80000view08:21, 30 April 2015ZariChanged box for CyclinD and CdK
71377view18:39, 17 October 2013MaintBotAutomated update of data sources
67270view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63189view20:50, 8 May 2013MaintBotUpdating gpml version
45301view19:58, 7 October 2011AlexanderPicoOntology Term : 'cell cycle checkpoint pathway' added !
41128view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38746view22:18, 23 September 2010Mark.scottccna1 link
38745view22:17, 23 September 2010Mark.scottconnect cdk1
35815view19:02, 17 February 2010KhanspersModified description
35814view18:36, 17 February 2010KhanspersAdded lit ref
32435view17:14, 15 August 2009MaintBotFixed text labels
32104view13:46, 14 August 2009MaintBotFixed group labels
20771view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP45]]: Moved to stable identifier
15393view22:27, 27 May 2008Khanspersconnectors
14438view22:42, 22 May 2008KhanspersAdded connectors, groups
14433view22:33, 22 May 2008KhanspersPeriodical save, work in progress
14427view22:30, 22 May 2008KhanspersAdded connectors
14423view22:23, 22 May 2008KhanspersPeriodical save, work in progress
14421view22:12, 22 May 2008KhanspersAdded connectors
14407view20:10, 22 May 2008KhanspersAdded connectors
12942view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
7944view13:46, 7 January 2008MaintBot[[Pathway:Human:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]]: Renaming species
7597view16:03, 18 December 2007MaintBotfixed category names
7205view12:33, 4 November 2007MaintBotAdded categories to GPML
6300view22:17, 22 May 2007A.C.Zambongpml file for [[Human:Cell_Cycle-G1_to_S_control_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATMGeneProduct472 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CCNG2GeneProduct901 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC2AGeneProduct
CDC45LGeneProduct8318 (Entrez Gene)
CDKGeneProduct
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN1CGeneProduct1028 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CREB3GeneProduct10488 (Entrez Gene)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L3GeneProduct84699 (Entrez Gene)
CREB3L4GeneProduct148327 (Entrez Gene)
CREBL1GeneProduct1388 (Entrez Gene)
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
E2F4GeneProduct1874 (Entrez Gene)
E2F5GeneProduct1875 (Entrez Gene)
E2F6GeneProduct1876 (Entrez Gene)
E2fGeneProduct
GADD45AGeneProduct1647 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYT1GeneProduct4661 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProduct5558 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBL1GeneProduct5933 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)

Annotated Interactions

No annotated interactions
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