Mitotic G1 phase and G1/S transition (Homo sapiens)

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13512232, 3350182116, 18-2026, 2725183011934-3714, 16, 1724311028, 2923122, 32424, 28, 2914, 155116, 1738-49nucleoplasmcytosolMcm10ATPRNA primer-DNA primer:origin duplex with DNA damageCyclin DRb-E2F:DP-1 complexADPDNA polymerase alpha:primase:DNA polymerase alpha:origin complexCyclin E1:phospho-Cdk2 complexSCF(Skp2) complexDP-1:E2F1 complexATPATPCyclin E:Phospho-Cdk2(Thr160):Rb complexCdc45p21/p27Mcm2-7 complexORC:originRb1:RNA primer-DNA primer:origin duplex with DNA damageCyclin E/A:Cdk2:p27/p21 complexCDK:DDK:Mcm10:pre-replicative complexp21Cyclin E2:Cdk2 complexCyclin B:Cdk1 complexADPCDT1Cyclin E/A:Cdk2:phospho-p27/p21ATPCdc45:CDK:DDK:Mcm10:pre-replicative complexCdk4/6:INK4A complexATPp21/p27INK4AMcm10:active pre-replicative complexCyclin E:Cdk2 complexDNA polymerase alpha:primaseATPCyclin E1:Cdk2 complexCdk4/6ADPCyclin EADPorigin of replicationPP2AADPCyclin E/A:Cdk2Cyclin E:phospho-Cdk2 (Thr 160):phospho-RbMyc/Max heterodimerADPp27Kip1Cyclin E/A:Cdk2:phospho-p27/p21:SCF(Skp2):Cks1 complexubiquitinADPRNA primer-DNA primer:origin duplexMyt1 kinaseRPA:Cdc45:CDK:DDK:Mcm10:pre-replicative complexADPWee1Cyclin E:phospho-Cdk2 Complexp27DNA polymerase epsilonCyclin E:Cdk2:p21/p27 complexphosphorylated Mcm2-7 complexCdk4/6DDKCdk2ORC:origin:cyclin B:cdk1 complexCks1Aborted replication complexpre-replicative complexSCF(Skp2):Cks1 complexATPATPCyclin D:phospho-CDK4/6:p21/p27CDKCyclin D:Cdk4/6:p21/p27CAKphospho-Retinoblastoma proteinp21ADPCdc25ACyclin E:Cdk2 complexesOrthophosphateMcm10:pre-replicative complexATPCyclin E:Phosho-Cdk2 (Thr 160)Retinoblastoma Protein 1Cyclin D:CDK4/6:p21/p27 complex26S proteasomeH2OATPADPDNA Replication Factor ACyclin E/A:Cdk2:multiubiquitinated phospho-p27/p21:SCF(Skp2):Cks1 complexDP-1:E2F complexE2F1 targetsCyclin E2:phospho-Cdk2 complexDNA polymerase epsilon:origin complex167, 82, 354


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  251. Kardinal C, Dangers M, Kardinal A, Koch A, Brandt DT, Tamura T, Welte K.; ''Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.''; PubMed Europe PMC Scholia
  252. Cobrinik D.; ''Pocket proteins and cell cycle control.''; PubMed Europe PMC Scholia
  253. Fan G, Lin G, Lucito R, Tonks NK.; ''Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.''; PubMed Europe PMC Scholia
  254. Aprelikova O, Xiong Y, Liu ET.; ''Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.''; PubMed Europe PMC Scholia
  255. Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ.; ''ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114646view16:11, 25 January 2021ReactomeTeamReactome version 75
113094view11:15, 2 November 2020ReactomeTeamReactome version 74
112328view15:25, 9 October 2020ReactomeTeamReactome version 73
112225view14:39, 2 October 2020DeSlOntology Term : 'M/G1 transition pathway' added !
101227view11:12, 1 November 2018ReactomeTeamreactome version 66
100765view20:38, 31 October 2018ReactomeTeamreactome version 65
100309view19:15, 31 October 2018ReactomeTeamreactome version 64
99855view15:59, 31 October 2018ReactomeTeamreactome version 63
99413view14:35, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93757view13:34, 16 August 2017ReactomeTeamreactome version 61
93279view11:19, 9 August 2017ReactomeTeamreactome version 61
86357view09:16, 11 July 2016ReactomeTeamreactome version 56
83315view10:46, 18 November 2015ReactomeTeamVersion54
81454view12:59, 21 August 2015ReactomeTeamVersion53
76928view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76633view12:00, 16 July 2014ReactomeTeamFixed remaining interactions
76130view12:48, 11 June 2014Anwesha
76129view12:44, 11 June 2014ReactomeTeamAdding missing reactome URL
75666view10:57, 10 June 2014ReactomeTeamReactome 48 Update
75021view13:53, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74665view08:43, 30 April 2014ReactomeTeamReactome46
68884view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
44912view10:35, 6 October 2011MartijnVanIerselOntology Term : 'cell cycle pathway, mitotic' added !
42076view21:55, 4 March 2011MaintBotAutomatic update
39884view05:54, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S

proteasome

ComplexREACT_7467 (Reactome)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Aborted replication

complex

ComplexREACT_2817 (Reactome)
CAK ComplexREACT_5717 (Reactome)
CDK ComplexREACT_5476 (Reactome)
CDK:DDK:Mcm10:

pre-replicative complex

ComplexREACT_2458 (Reactome)
CDT1 ProteinQ9H211 (UniProt)
Cdc25A ProteinP30304 (UniProt)
Cdc45 ProteinO75419 (UniProt)
Cdc45:CDK:DDK:

Mcm10:pre- replicative complex

ComplexREACT_4546 (Reactome)
Cdk2 ProteinP24941 (UniProt)
Cdk4/6 UnknownREACT_4552 (Reactome)
Cdk4/6 ProteinREACT_8720 (Reactome)
Cdk4/6:INK4A complex ComplexREACT_8076 (Reactome)
Cks1 ProteinP61024 (UniProt)
Cyclin B:Cdk1

complex

ComplexREACT_4583 (Reactome)
Cyclin D ProteinREACT_8063 (Reactome)
Cyclin D:CDK4/6:

p21/p27 complex

ComplexREACT_2341 (Reactome)
Cyclin D:Cdk4/6:

p21/p27

ComplexREACT_2453 (Reactome)
Cyclin D:phospho-

CDK4/6:p21/p27

ComplexREACT_3625 (Reactome)
Cyclin E ProteinREACT_5284 (Reactome)
Cyclin E/A:

Cdk2:phospho- p27/p21

ComplexREACT_9321 (Reactome)
Cyclin E/A:Cdk2 ComplexREACT_9091 (Reactome)
Cyclin E/A:Cdk2:

multiubiquitinated phospho-p27/p21: SCF(Skp2):Cks1 complex

ComplexREACT_9266 (Reactome)
Cyclin E/A:Cdk2:

p27/p21 complex

ComplexREACT_9314 (Reactome)
Cyclin E/A:Cdk2:

phospho-p27/p21: SCF(Skp2):Cks1 complex

ComplexREACT_9193 (Reactome)
Cyclin E1:Cdk2

complex

ComplexREACT_4601 (Reactome)
Cyclin E1:phospho-

Cdk2 complex

ComplexREACT_2714 (Reactome)
Cyclin E2:Cdk2

complex

ComplexREACT_5296 (Reactome)
Cyclin E2:phospho-

Cdk2 complex

ComplexREACT_3967 (Reactome)
Cyclin E:Cdk2

complexes

ComplexREACT_5247 (Reactome)
Cyclin E:Cdk2 complex ComplexREACT_3296 (Reactome)
Cyclin E:Cdk2:

p21/p27 complex

ComplexREACT_3804 (Reactome)
Cyclin E:Phosho-

Cdk2 (Thr 160)

ComplexREACT_9167 (Reactome)
Cyclin E:Phospho-

Cdk2(Thr160):Rb complex

ComplexREACT_9136 (Reactome)
Cyclin E:phospho-

Cdk2 (Thr 160): phospho-Rb

ComplexREACT_9190 (Reactome)
Cyclin E:phospho-

Cdk2 Complex

ComplexREACT_4112 (Reactome)
DDK ComplexREACT_4813 (Reactome)
DNA Replication Factor

A

ComplexREACT_5149 (Reactome)
DNA polymerase

alpha:primase

ComplexREACT_3725 (Reactome)
DNA polymerase

alpha:primase:DNA polymerase alpha: origin complex

ComplexREACT_3167 (Reactome)
DNA polymerase

epsilon

ComplexREACT_4621 (Reactome)
DNA polymerase

epsilon:origin complex

ComplexREACT_3283 (Reactome)
DP-1:E2F

complex

ComplexREACT_2896 (Reactome)
DP-1:E2F1 complex ComplexREACT_5400 (Reactome)
E2F1 targets ProteinREACT_22550 (Reactome)
H2O Metabolite15377 (ChEBI)
INK4A UnknownREACT_8915 (Reactome)
Mcm10 ProteinQ7L590 (UniProt)
Mcm10:active

pre-replicative complex

ComplexREACT_2683 (Reactome)
Mcm10:pre-

replicative complex

ComplexREACT_5685 (Reactome)
Mcm2-7

complex

ComplexREACT_4763 (Reactome)
Myc/Max

heterodimer

ComplexREACT_9233 (Reactome)
Myt1 kinase ProteinQ99640 (UniProt)
ORC:origin ComplexREACT_3844 (Reactome)
ORC:origin:cyclin B:

cdk1 complex

ComplexREACT_4235 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PP2A UnknownREACT_5265 (Reactome)
RNA primer-DNA

primer:origin duplex

ComplexREACT_5497 (Reactome)
RNA primer-DNA

primer:origin duplex with DNA damage

ComplexREACT_2843 (Reactome)
RPA:Cdc45:CDK:DDK:

Mcm10:pre- replicative complex

ComplexREACT_2568 (Reactome)
Rb-E2F:DP-1

complex

ComplexREACT_4483 (Reactome)
Rb1:RNA primer-DNA

primer:origin duplex with DNA damage

ComplexREACT_3869 (Reactome)
Retinoblastoma

Protein 1

ProteinP06400 (UniProt)
SCF(Skp2) complex ComplexREACT_9339 (Reactome)
SCF(Skp2):Cks1

complex

ComplexREACT_9182 (Reactome)
Wee1 ProteinP30291 (UniProt)
origin of

replication

UnknownREACT_3087 (Reactome)
p21 ProteinP38936 (UniProt)
p21/p27 ProteinREACT_8233 (Reactome)
p21/p27 ProteinREACT_8306 (Reactome)
p27 ProteinP46527 (UniProt)
p27Kip1 ProteinP46527 (UniProt)
phospho-

Retinoblastoma protein

ProteinP06400 (UniProt)
phosphorylated

Mcm2-7 complex

ComplexREACT_4259 (Reactome)
pre-replicative

complex

ComplexREACT_4388 (Reactome)
ubiquitin ProteinREACT_3995 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1858"
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