Toll-like receptor signaling pathway (Bos taurus)

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ImidazoquinolinbiosynthesiseffectsCpG DNAcoagulation cascades+p+pIKKT cell stimulationPeptidoglycan(G+)(Neutrophil, immature DC,UnmethylatedFlagellar assembly+pApoptosiseffectsAntiviral effectsCytokine-Costimulatory molecules+pMAPK signaling pathway+pInflammatory cytokinesChemotacticssRNA+NK cell)Inflammatory cytokines+p+pDNADegradationLPS(G-)LipoproteinZymosan (Yeast)+pMyD88-independent pathwaydsRNA(anti-viral compounds)Complement andSpecific pathwayin pDCsEndosomeFlagellin+pcytokine receptor(Mycobacteria)MyD88-dependent pathway+p+p+effects+pAutocrine / Paracrine(T cell)+pProinflammatoryLipoarabinomannanUbiquitin mediated proteolysisJak-STAT signaling pathwayChemotacticLipopolysaccharideinteraction+p+pIFNAR2TOLLIPAKT1CD86NFKB2TIRAPIL6LBPCXCL9STAT1MYD88IL12BPIK3CDCHUKIKBKENFKBIAAKT2IRF7TRAF6IFNA7IFNA8TLR5TICAM2MAP2K4PIK3CAMAPK10IRF5RIPK1PIK3CGCD80TLR6SPP1TNFMAPK9MAP3K8FADDTLR8TLR1IRF3RELAMAP2K1MAPK11MAP3K7IP1IFNB1MAP3K7IP2RAC1IFNA5IFNB1MYD88TLR2CXCL11CD14IFNA1IFNA2IRAK1LOC100137872TLR4PIK3R2MYD88MAPK13MAPK14TLR3CCL5TRAF3PIK3CBFOSIL1BMAP2K2MAP2K3CXCL10IRAK4MAP2K7IFNAR1IFNB1PIK3R5IFNA17IL8MYD88IKBKBTBK1TLR7CD40IRAK4IFNA13TRAF6MAPK3IFNA21MAP3K7IKBKGLY96CCL3CHUKJUNNFKB1IRAK1MAPK8NFKB1IL12AMAP2K6TRAF6IFNA6MAPK12IFNA14IFNA16TIRAPTLR9PIK3R1IFNA4MAPK1TLR2TICAM1PIK3R3IFNA10CCL4CASP8


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 82% conversion rate.

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Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
122566view10:33, 16 April 2022EgonwMade a pathway clickable
115321view09:12, 13 February 2021EgonwMade four pathways clickable
80730view15:23, 30 June 2015Mkutmonhomology conversion
63387view00:03, 10 May 2013MaintBotUpdated to 2013 gpml schema
40560view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
33798view00:15, 9 December 2009MaintBotAutomatic update of empty xrefs
32525view12:57, 17 August 2009MaintBotFixed text labels
32211view12:43, 15 August 2009MaintBotFixed text labels
31699view11:49, 14 August 2009MaintBotFixed group labels
31223view19:42, 13 August 2009MaintBotFixed text labels
30636view22:28, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct280991 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct534923 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CASP8GeneProduct507481 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct282170 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct414347 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct327712 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct281048 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD40GeneProduct286849 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct407131 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct414345 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct281073 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CXCL10GeneProduct615107 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct516104 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct513990 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FADDGeneProduct493720 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FOSGeneProduct280795 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct281843 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProduct282256 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct281844 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct282257 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct282258 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct281845 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct281854 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct533216 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct281855 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct281856 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct281857 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct281251 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct280826 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct280828 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct533953 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct533692 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct516979 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct615340 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct100125591 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JUNGeneProduct280831 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct512242 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LOC100137872GeneProduct100137872 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
LY96GeneProduct613753 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct533199 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct510434 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct516039 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct526469 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct286883 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct787278 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct529146 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct519958 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProduct540203 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct535622 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct537631 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct618906 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct512943 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct327672 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK13GeneProduct535327 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct534492 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK3GeneProduct531391 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct539941 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct534125 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MYD88GeneProduct444881 (Entrez Gene) Original kegg element: gene;47;hsa:4615
NFKB1GeneProduct616115 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct526392 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct282291 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct282306 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct517948 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct504531 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct530001 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct282307 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct282308 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct286865 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct614838 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
RAC1GeneProduct281440 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RELAGeneProduct508233 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct504727 (Entrez Gene) Original kegg element: gene;17;hsa:8737
SPP1GeneProduct281499 (Entrez Gene) Original kegg element: gene;15;hsa:6696
STAT1GeneProduct510814 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TBK1GeneProduct533141 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct510427 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2GeneProduct539350 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TIRAPGeneProduct531079 (Entrez Gene) Original kegg element: gene;83;hsa:114609
TLR1GeneProduct574090 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct281534 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR3GeneProduct281535 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct281536 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR5GeneProduct444870 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct407237 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct493686 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct532262 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct282602 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct280943 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TOLLIPGeneProduct539480 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct506182 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct539124 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1067"
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