Insulin signaling (Canis familiaris)
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1
Transcriptional Regulators & Immediate Early Genes
Metabolic Regulation
p90 Rsk Kinases
PDK/Akt Signaling
Ras-MAPK Signaling
Vesicular Trafficking
Tor Signaling
PI 3-Kinase
p70 S6 Kinases
Insulin Receptor Substrates
MEK/MAP Kinases
Translation Regulation
Glucose Transport
Modulators of Insulin Action
PFKL
GRB14
LOC477681
CBL
PRKAA2
IRS4
MAP3K10
MAP4K3
PRKCD
PIK3CB
SOS1
EIF4E
LIPE
GYS2
RPS6KA4
GSK3A
EGR1
MAPK7
SGK2
SH2B2
FLOT1
RPS6KA6
MAPK3
RPS6KA2
IRS1
INSR
SOCS1
SNAP23
RAPGEF1
RRAD
PTEN
CBLC
FLOT2
MAPK1
JUN
XBP1
SNX26
KIF3A
TRIB3
MAP4K1
MAP3K8
MAP3K2
PIK3C2A
MAP3K12
RPS6KA5
PIK3R3
CBLB
RPS6KB1
MAPK12
TBC1D4
RAC2
LOC476352
RHOXF2
PIK3CG
GSK3B
EHD2
FOXO3A
RAC1
STXBP2
PTPN1
IGF1R
MAP2K2
MAP3K5
MAP2K1
AKT2
MAPK8
RAB4A
MAP2K3
STX4
MAPK6
STXBP3
SOS2
GAB1
CAP1
PRKCZ
HRAS
MAPK14
SGK1
PRKCB
GYG1
MAP3K7
INPPL1
MAPK9
MAP4K5
MAPK13
GRB10
IRS2
MAPK11
PIK3R1
PRKAA1
SORBS1
FOS
MAP4K2
RPS6KB2
TSC1
MAP2K6
MAP2K4
SLC2A1
SGK3
TSC2
VAMP2
EHD1
AKT1
PRKCH
RPS6KA3
RHEB
STXBP1
EIF4EBP1
PIK3C3
SRF
MAP3K1
ARF1
MAP4K4
MAP3K4
MYO1C
RPS6KA1
MAP3K3
PIK3CD
MAPK10
MAP3K9
PTPN11
PPP1R3A
SHC2
MAP3K11
GYS1
SLC2A4
MAP2K5
GRB2
CYTH3
RHOQ
ELK1
INPP4A
MAP2K7
RHOJ
PDPK1
PFKM
FOXO1
SOCS3
PIK3R4
SHC1
MAP3K14
PRKCA
PRKCI
MINK1
PRKCQ
MAPK8
ARF6
RAF1
STXBP4
MAP3K13
MTOR
MAPK4
ENPP1
CRK
SNAP25
PIK3CA
KIF5B
MAP3K6
IKBKB
PTPRF
PIK3R2
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP481(r28132)
with a 90% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
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Bibliography
Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001
PubMed
Europe PMC
Scholia
Bevan P; ''Insulin signalling.''; J Cell Sci, 2001
PubMed
Europe PMC
Scholia
Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
129527
view
01:16, 9 May 2024
Eweitz
Modified title
125471
view
13:29, 16 February 2023
Mkutmon
fix complexes
125470
view
13:28, 16 February 2023
Mkutmon
fix complexes and unconnected lines
125469
view
13:08, 16 February 2023
Egonw
Removed the Last-Modified attribute
68506
view
21:50, 5 July 2013
MaintBot
Updated to 2013 gpml schema
48159
view
18:56, 9 May 2012
MaintBot
Updating from human to fix xrefs
40657
view
21:48, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33949
view
18:20, 9 December 2009
MaintBot
Automatic update of empty xrefs
32535
view
13:01, 17 August 2009
MaintBot
Fixed text labels
32222
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12:46, 15 August 2009
MaintBot
Fixed text labels
31718
view
11:54, 14 August 2009
MaintBot
Fixed group labels
31233
view
19:45, 13 August 2009
MaintBot
Fixed text labels
30654
view
22:34, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
AKT1
GeneProduct
490878 (Entrez Gene)
AKT2
GeneProduct
449021 (Entrez Gene)
ARF1
GeneProduct
474591 (Entrez Gene)
ARF6
GeneProduct
490679 (Entrez Gene)
CAP1
GeneProduct
475317 (Entrez Gene)
CBL
GeneProduct
CBLB
GeneProduct
487965 (Entrez Gene)
CBLC
GeneProduct
612343 (Entrez Gene)
CRK
GeneProduct
CYTH3
GeneProduct
609100 (Entrez Gene)
EGR1
GeneProduct
481528 (Entrez Gene)
EHD1
GeneProduct
EHD2
GeneProduct
484417 (Entrez Gene)
EIF4E
GeneProduct
487870 (Entrez Gene)
EIF4EBP1
GeneProduct
475590 (Entrez Gene)
ELK1
GeneProduct
491860 (Entrez Gene)
ENPP1
GeneProduct
476153 (Entrez Gene)
FLOT1
GeneProduct
474831 (Entrez Gene)
FLOT2
GeneProduct
610963 (Entrez Gene)
FOS
GeneProduct
490792 (Entrez Gene)
FOXO1
GeneProduct
477295 (Entrez Gene)
FOXO3A
GeneProduct
GAB1
GeneProduct
483808 (Entrez Gene)
GRB10
GeneProduct
GRB14
GeneProduct
478770 (Entrez Gene)
GRB2
GeneProduct
483312 (Entrez Gene)
GSK3A
GeneProduct
484476 (Entrez Gene)
GSK3B
GeneProduct
478575 (Entrez Gene)
GYG1
GeneProduct
611614 (Entrez Gene)
GYS1
GeneProduct
GYS2
GeneProduct
403737 (Entrez Gene)
HRAS
GeneProduct
IGF1R
GeneProduct
442951 (Entrez Gene)
IKBKB
GeneProduct
482839 (Entrez Gene)
INPP4A
GeneProduct
474563 (Entrez Gene)
INPPL1
GeneProduct
485209 (Entrez Gene)
INSR
GeneProduct
484990 (Entrez Gene)
IRS1
GeneProduct
486148 (Entrez Gene)
IRS2
GeneProduct
485548 (Entrez Gene)
IRS4
GeneProduct
492059 (Entrez Gene)
JUN
GeneProduct
609429 (Entrez Gene)
KIF3A
GeneProduct
474675 (Entrez Gene)
KIF5B
GeneProduct
477968 (Entrez Gene)
LIPE
GeneProduct
403607 (Entrez Gene)
LOC476352
GeneProduct
476352 (Entrez Gene)
LOC477681
GeneProduct
477681 (Entrez Gene)
MAP2K1
GeneProduct
478347 (Entrez Gene)
MAP2K2
GeneProduct
611939 (Entrez Gene)
MAP2K3
GeneProduct
489547 (Entrez Gene)
MAP2K4
GeneProduct
489508 (Entrez Gene)
MAP2K5
GeneProduct
MAP2K6
GeneProduct
480454 (Entrez Gene)
MAP2K7
GeneProduct
485004 (Entrez Gene)
MAP3K10
GeneProduct
484504 (Entrez Gene)
MAP3K11
GeneProduct
483732 (Entrez Gene)
MAP3K12
GeneProduct
607170 (Entrez Gene)
MAP3K13
GeneProduct
MAP3K14
GeneProduct
490926 (Entrez Gene)
MAP3K1
GeneProduct
478061 (Entrez Gene)
MAP3K2
GeneProduct
612902 (Entrez Gene)
MAP3K3
GeneProduct
480481 (Entrez Gene)
MAP3K4
GeneProduct
476262 (Entrez Gene)
MAP3K5
GeneProduct
476215 (Entrez Gene)
MAP3K6
GeneProduct
487345 (Entrez Gene)
MAP3K7
GeneProduct
474996 (Entrez Gene)
MAP3K8
GeneProduct
487085 (Entrez Gene)
MAP3K9
GeneProduct
490765 (Entrez Gene)
MAP4K1
GeneProduct
484527 (Entrez Gene)
MAP4K2
GeneProduct
483759 (Entrez Gene)
MAP4K3
GeneProduct
475734 (Entrez Gene)
MAP4K4
GeneProduct
481331 (Entrez Gene)
MAP4K5
GeneProduct
490685 (Entrez Gene)
MAPK10
GeneProduct
478464 (Entrez Gene)
MAPK11
GeneProduct
607019 (Entrez Gene)
MAPK12
GeneProduct
607023 (Entrez Gene)
MAPK13
GeneProduct
612821 (Entrez Gene)
MAPK14
GeneProduct
403856 (Entrez Gene)
MAPK1
GeneProduct
477575 (Entrez Gene)
MAPK3
GeneProduct
486758 (Entrez Gene)
MAPK4
GeneProduct
491690 (Entrez Gene)
MAPK6
GeneProduct
478311 (Entrez Gene)
MAPK7
GeneProduct
489532 (Entrez Gene)
MAPK8
GeneProduct
477746 (Entrez Gene)
MAPK9
GeneProduct
474652 (Entrez Gene)
MINK1
GeneProduct
MTOR
GeneProduct
478232 (Entrez Gene)
MYO1C
GeneProduct
480646 (Entrez Gene)
PDPK1
GeneProduct
479875 (Entrez Gene)
PFKL
GeneProduct
487797 (Entrez Gene)
PFKM
GeneProduct
403849 (Entrez Gene)
PIK3C2A
GeneProduct
485399 (Entrez Gene)
PIK3C3
GeneProduct
490477 (Entrez Gene)
PIK3CA
GeneProduct
488084 (Entrez Gene)
PIK3CB
GeneProduct
477085 (Entrez Gene)
PIK3CD
GeneProduct
489644 (Entrez Gene)
PIK3CG
GeneProduct
483266 (Entrez Gene)
PIK3R1
GeneProduct
487235 (Entrez Gene)
PIK3R2
GeneProduct
609956 (Entrez Gene)
PIK3R3
GeneProduct
482512 (Entrez Gene)
PIK3R4
GeneProduct
477064 (Entrez Gene)
PPP1R3A
GeneProduct
482411 (Entrez Gene)
PRKAA1
GeneProduct
479351 (Entrez Gene)
PRKAA2
GeneProduct
489571 (Entrez Gene)
PRKCA
GeneProduct
490904 (Entrez Gene)
PRKCB
GeneProduct
489968 (Entrez Gene)
PRKCD
GeneProduct
494005 (Entrez Gene)
PRKCH
GeneProduct
490722 (Entrez Gene)
PRKCI
GeneProduct
478686 (Entrez Gene)
PRKCQ
GeneProduct
478013 (Entrez Gene)
PRKCZ
GeneProduct
479577 (Entrez Gene)
PTEN
GeneProduct
403832 (Entrez Gene)
PTPN11
GeneProduct
477488 (Entrez Gene)
PTPN1
GeneProduct
477263 (Entrez Gene)
PTPRF
GeneProduct
475389 (Entrez Gene)
RAB4A
GeneProduct
479210 (Entrez Gene)
RAC1
GeneProduct
403955 (Entrez Gene)
RAC2
GeneProduct
481271 (Entrez Gene)
RAF1
GeneProduct
484648 (Entrez Gene)
RAPGEF1
GeneProduct
491286 (Entrez Gene)
RHEB
GeneProduct
475545 (Entrez Gene)
RHOJ
GeneProduct
612985 (Entrez Gene)
RHOQ
GeneProduct
474579 (Entrez Gene)
RHOXF2
GeneProduct
611154 (Entrez Gene)
RPS6KA1
GeneProduct
487353 (Entrez Gene)
RPS6KA2
GeneProduct
612448 (Entrez Gene)
RPS6KA3
GeneProduct
491768 (Entrez Gene)
RPS6KA4
GeneProduct
612105 (Entrez Gene)
RPS6KA5
GeneProduct
490831 (Entrez Gene)
RPS6KA6
GeneProduct
491989 (Entrez Gene)
RPS6KB1
GeneProduct
480580 (Entrez Gene)
RPS6KB2
GeneProduct
610499 (Entrez Gene)
RRAD
GeneProduct
611304 (Entrez Gene)
SGK1
GeneProduct
403647 (Entrez Gene)
SGK2
GeneProduct
SGK3
GeneProduct
486981 (Entrez Gene)
SH2B2
GeneProduct
489820 (Entrez Gene)
SHC1
GeneProduct
490439 (Entrez Gene)
SHC2
GeneProduct
611955 (Entrez Gene)
SLC2A1
GeneProduct
482437 (Entrez Gene)
SLC2A4
GeneProduct
403673 (Entrez Gene)
SNAP23
GeneProduct
478268 (Entrez Gene)
SNAP25
GeneProduct
477158 (Entrez Gene)
SNX26
GeneProduct
484573 (Entrez Gene)
SOCS1
GeneProduct
490006 (Entrez Gene)
SOCS3
GeneProduct
442949 (Entrez Gene)
SORBS1
GeneProduct
SOS1
GeneProduct
483042 (Entrez Gene)
SOS2
GeneProduct
490682 (Entrez Gene)
SRF
GeneProduct
612861 (Entrez Gene)
STX4
GeneProduct
489919 (Entrez Gene)
STXBP1
GeneProduct
STXBP2
GeneProduct
403880 (Entrez Gene)
STXBP3
GeneProduct
490128 (Entrez Gene)
STXBP4
GeneProduct
491094 (Entrez Gene)
TBC1D4
GeneProduct
485494 (Entrez Gene)
TRIB3
GeneProduct
485819 (Entrez Gene)
TSC1
GeneProduct
480688 (Entrez Gene)
TSC2
GeneProduct
479883 (Entrez Gene)
VAMP2
GeneProduct
479491 (Entrez Gene)
XBP1
GeneProduct
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions