Transforming growth factor (TGF) beta receptor signaling (Canis familiaris)

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Proteins in a complex interactionEndosomeCYCYNU -> CYDephosphorylationNUGOCYNUCYNUCYAcetylationNUCytoplasmNUPMNUReceptorMTGolgi apparatusNUNUNUAutophosphorylationNUUbiquitinationCYCYLigandDesumoylationNUCYPalmitoylationNucleusPhosphorylationDControlNUCYCYCYCYNUDeacetylationRecruitmentNUCYNUNUNUReaction through unknown mechanisms/moleculesNU -> CYCYMitochondriaCYEnzyme complexCYNUNUMolecule in the pathwayPlasma membraneDemethylationAccession Number: NetPath 7; cellmap:7NUNUSumoylationGlycosylationMolecular associationDeubiquitinationExtracellularECCYEndoplasmic reticulumCYCYGlycosylationENNUCYNUNUERNUCYNU(Protein-protein interaction)ActivationInhibitionTranslocationProteolytic cleavageCYCYCYCYCYMethylationNUCYSTK11SMAD3NFYBACVRL1FOSTGFB3STAMBPL1RBX1EIF3IE2F4TRAP1SMAD4TGFB2SMAD7JUNDTGFB3PIAS1TGFBR3TGFBR2MEF2AKPNB1NFYAATF3TGFB1CDC2STRAPDAB2AP2B1E2F4ANAPC5LEF1SMAD7PRKCGANAPC10CUL1CAMK2ATGFBR1CAV1PIK3R1TGFBR2PRKCBPRKCDGIPC1ANAPC7CREBBPTGFBR2ATF2SMURF2CDK4TGFB1SDC2MAPK8TFDP1TGFBR1TGFBR2SMAD3RBL1SMAD3DCP1ASKIMYCTGFBR3PRKAR1BRB1SMAD2SMURF2SMAD4HSPA8ANAPC4KAT2BCDC25ACD44SNX4ETS1XPO1VDRCUL1STRAPFNTAMAPK8CDC27BTRCSMAD2PPP2R2ASP1FOXG1TGIFTGFBR3MAPK14RB1HNF4ACTNNB1SUMO1ZEB2UBE2D1UBE2D3KPNB1SMAD3EP300HOXA9TGFB3ESR1CITED1YAP1PRKAR2ARBX1ANAPC1TFDP2ENGE2F4SMURF1RBL1CTCFTGFBR3LOC487309ESR1MAP2K3TFDP2TP73MAP3K7ZEB1CDC16FOSBCCND1SPARCSNX1NUP153SMAD3E2F4FOXO4DCP1ARB1PIAS2FOXO3ADAXXROCK1SNX6Gene SymbolSMURF1TGFBR2UBE2D2ANAPC10TGFBR1SKP1NFYCANAPC4ANAPC7CDC23RBL2MAP3K7IP1E2F5CDK2PARD3SMAD3TGFBR2HGSSMAD4TGFBR1SMAD4SMAD4ARRB2E2F5CDC27TP53BTRCSMAD3SNW1CDKN1ASKILCAMK2GFKBP1ATFDP2FOXO1TFDP1TGFB1RUNX2TGFB1SMAD2CUL1SMAD3PIK3R2CDC16TGFBR3JUNBLOC612523FOXH1E2F5CDC27E2F5E2F5RBL1CDK6NCOA1SMAD3FZR1TGFBR3SMAD7NUP214SMAD4RBL1TGFBR2ANAPC5ZFYVE9RBL1RBX1TFDP1RBL2CAMK2BSMAD6E2F5AXIN2TGFB2JUNCCNB2SNX6TGFBR2E2F4SNX2TGFB3MAPK14DVL1COPS5TGFB2MEF2CSTK11IPSKP1ANAPC1CCNE1ERBB2IPSMAD2AXIN1ANAPC2ARROCK1SNIP1MAP2K6TGFBR2ANAPC2CAMK2DE2F4CDC23TGFBR2


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 92% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
129684view00:46, 22 May 2024EweitzModified title
118020view11:36, 23 May 2021EweitzModified title
87756view09:56, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87754view09:56, 25 July 2016MirellaKalafatiModified title
87753view09:55, 25 July 2016MirellaKalafatiModified title
68533view22:17, 5 July 2013MaintBotUpdated to 2013 gpml schema
40689view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
33975view18:29, 9 December 2009MaintBotAutomatic update of empty xrefs
31279view20:01, 13 August 2009MaintBotFixed text labels
30730view22:59, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACVRL1GeneProduct477603 (Entrez Gene)
ANAPC10GeneProduct475453 (Entrez Gene)
ANAPC1GeneProduct475750 (Entrez Gene)
ANAPC2GeneProduct491236 (Entrez Gene)
ANAPC4GeneProduct479123 (Entrez Gene)
ANAPC5GeneProduct477471 (Entrez Gene)
ANAPC7GeneProduct486264 (Entrez Gene)
AP2B1GeneProduct480605 (Entrez Gene)
ARGeneProduct403588 (Entrez Gene)
ARRB2GeneProduct607262 (Entrez Gene)
ATF2GeneProduct478806 (Entrez Gene)
ATF3GeneProduct612911 (Entrez Gene)
AXIN1GeneProduct490099 (Entrez Gene)
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BTRCGeneProduct486851 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct610764 (Entrez Gene)
CAMK2GGeneProduct489050 (Entrez Gene)
CAV1GeneProduct403980 (Entrez Gene)
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CDC16GeneProduct607100 (Entrez Gene)
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CDC25AGeneProduct484780 (Entrez Gene)
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CDKN1AGeneProduct474890 (Entrez Gene)
CITED1GeneProduct607904 (Entrez Gene)
COPS5GeneProduct477901 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
CTCFGeneProduct479684 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
DAB2GeneProduct479353 (Entrez Gene)
DAXXGeneProduct474873 (Entrez Gene)
DCP1AGeneProduct607346 (Entrez Gene)
DVL1GeneProduct489593 (Entrez Gene)
E2F4GeneProduct611243 (Entrez Gene)
E2F5GeneProduct611103 (Entrez Gene)
EIF3IGeneProduct478152 (Entrez Gene)
ENGGeneProduct609166 (Entrez Gene)
EP300GeneProduct
ERBB2IPGeneProduct478082 (Entrez Gene)
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ETS1GeneProduct489287 (Entrez Gene)
FKBP1AGeneProduct608169 (Entrez Gene)
FNTAGeneProduct475566 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
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FOXO3AGeneProduct
FOXO4GeneProduct491946 (Entrez Gene)
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Gene SymbolGeneProduct
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HOXA9GeneProduct482372 (Entrez Gene)
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JUNBGeneProduct484927 (Entrez Gene)
JUNDGeneProduct609409 (Entrez Gene)
KAT2BGeneProduct477052 (Entrez Gene)
KPNB1GeneProduct491042 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
LOC612523GeneProduct612523 (Entrez Gene)
MAP2K3GeneProduct489547 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
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NFYCGeneProduct475312 (Entrez Gene)
NUP153GeneProduct478732 (Entrez Gene)
NUP214GeneProduct608534 (Entrez Gene)
PARD3GeneProduct477953 (Entrez Gene)
PIAS1GeneProduct478350 (Entrez Gene)
PIAS2GeneProduct480147 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PPP2R2AGeneProduct477374 (Entrez Gene)
PRKAR1BGeneProduct480805 (Entrez Gene)
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PRKCBGeneProduct489968 (Entrez Gene)
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PRKCGGeneProduct484316 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RBL2GeneProduct478127 (Entrez Gene)
RBX1GeneProduct474494 (Entrez Gene)
ROCK1GeneProduct480181 (Entrez Gene)
RUNX2GeneProduct449531 (Entrez Gene)
SDC2GeneProduct477945 (Entrez Gene)
SKIGeneProduct489610 (Entrez Gene)
SKILGeneProduct488159 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
SMAD2GeneProduct480144 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SMAD6GeneProduct487612 (Entrez Gene)
SMAD7GeneProduct490570 (Entrez Gene)
SMURF1GeneProduct608821 (Entrez Gene)
SMURF2GeneProduct480470 (Entrez Gene)
SNIP1GeneProduct475330 (Entrez Gene)
SNW1GeneProduct480405 (Entrez Gene)
SNX1GeneProduct478336 (Entrez Gene)
SNX2GeneProduct474657 (Entrez Gene)
SNX4GeneProduct478595 (Entrez Gene)
SNX6GeneProduct490648 (Entrez Gene)
SP1GeneProduct486507 (Entrez Gene)
SPARCGeneProduct612159 (Entrez Gene)
STAMBPL1GeneProduct477586 (Entrez Gene)
STK11GeneProduct485088 (Entrez Gene)
STK11IPGeneProduct488541 (Entrez Gene)
STRAPGeneProduct486663 (Entrez Gene)
SUMO1GeneProduct478874 (Entrez Gene)
TFDP1GeneProduct607720 (Entrez Gene)
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TGFB1GeneProduct403998 (Entrez Gene)
TGFB2GeneProduct488596 (Entrez Gene)
TGFB3GeneProduct490796 (Entrez Gene)
TGFBR1GeneProduct481628 (Entrez Gene)
TGFBR2GeneProduct477039 (Entrez Gene)
TGFBR3GeneProduct490163 (Entrez Gene)
TGIFGeneProduct
TP53GeneProduct403869 (Entrez Gene)
TP73GeneProduct489620 (Entrez Gene)
TRAP1GeneProduct490032 (Entrez Gene)
UBE2D1GeneProduct608578 (Entrez Gene)
UBE2D2GeneProduct612742 (Entrez Gene)
UBE2D3GeneProduct
VDRGeneProduct486588 (Entrez Gene)
XPO1GeneProduct474609 (Entrez Gene)
YAP1GeneProduct479465 (Entrez Gene)
ZEB1GeneProduct477966 (Entrez Gene)
ZEB2GeneProduct483909 (Entrez Gene)
ZFYVE9GeneProduct475352 (Entrez Gene)

Annotated Interactions

No annotated interactions
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