Methylation (Mus musculus)

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1, 2N-methylationO-methylationSAM synthesis (co-substrate)S-methylationNnmtS-AdenosylmethionineMat2aMat2bS-AdenosylhomocysteineS-AdenosylhomocysteinePhosphateN-methylated substrateATPHnmtL-MethionineS-AdenosylmethionineO-methylated substrateS-AdenosylmethionineS-AdenosylhomocysteineMat1aInmtSubstratePnmtComt1PhosphateTpmtS-methylated substrate


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP704(r30265) with a 100% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
  2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106838view13:31, 17 September 2019MaintBotHMDB identifier normalization
69203view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67461view11:04, 26 June 2013DdiglesOntology Term : 'protein modification pathway' added !
59072view21:23, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58512view19:12, 14 February 2013MaintBotModified title
41393view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
31852view12:32, 14 August 2009MaintBotFixed group labels
30833view00:02, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB00538 (HMDB)
Comt1GeneProductENSMUSG00000000326 (Ensembl Mouse)
HnmtGeneProductENSMUSG00000026986 (Ensembl Mouse)
InmtGeneProductENSMUSG00000003477 (Ensembl Mouse)
L-MethionineMetaboliteHMDB00696 (HMDB)
Mat1aGeneProductENSMUSG00000037798 (Ensembl Mouse)
Mat2aGeneProductENSMUSG00000053907 (Ensembl Mouse)
Mat2bGeneProductENSMUSG00000042032 (Ensembl Mouse)
N-methylated substrateMetabolite
NnmtGeneProductENSMUSG00000032271 (Ensembl Mouse)
O-methylated substrateMetabolite
PhosphateMetaboliteHMDB01429 (HMDB)
PnmtGeneProductENSMUSG00000038216 (Ensembl Mouse)
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TpmtGeneProductENSMUSG00000021376 (Ensembl Mouse)

Annotated Interactions

No annotated interactions
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