Mitotic G1 phase and G1/S transition (Homo sapiens)

From WikiPathways

Revision as of 17:26, 8 July 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
1814, 16, 17242328, 2916, 18-2022101218913503026, 2724, 28, 2916, 1714, 155138-495132, 332134-37251124312, 3nucleoplasmcytosolCyclin E:phospho-Cdk2 (Thr 160):phospho-RbADPDNA polymerase epsilonADPCyclin E2:Cdk2 complexRPA:Cdc45:CDK:DDK:Mcm10:pre-replicative complexMyc/Max heterodimerCyclin E/A:Cdk2:p27/p21 complexRNA primer-DNA primer:origin duplex with DNA damageCyclin D:CDK4/6:p21/p27 complexATPATPDDKDP-1:E2F1 complexorigin of replicationp21/p27CDT1Cyclin E/A:Cdk2:multiubiquitinated phospho-p27/p21:SCF(Skp2):Cks1 complexCyclin E/A:Cdk2Cdk4/6:INK4A complexCyclin E1:phospho-Cdk2 complexPP2ACDK:DDK:Mcm10:pre-replicative complexMcm10Cyclin E:Cdk2:p21/p27 complexCyclin E:Cdk2 complexesADPATPRetinoblastoma Protein 1p27Cdk2ORC:originpre-replicative complexphospho-Retinoblastoma proteinDNA Replication Factor Ap21ORC:origin:cyclin B:cdk1 complexCAKADPDNA polymerase alpha:primaseRNA primer-DNA primer:origin duplexCyclin E:Phospho-Cdk2(Thr160):Rb complexCyclin E/A:Cdk2:phospho-p27/p21:SCF(Skp2):Cks1 complexCyclin E:Phosho-Cdk2 (Thr 160)p21ATPATPSCF(Skp2) complexCks1Cyclin DDNA polymerase alpha:primase:DNA polymerase alpha:origin complexATPCdc45Cyclin D:Cdk4/6:p21/p27ATPE2F1 targetsDNA polymerase epsilon:origin complexCyclin E:Cdk2 complexMcm2-7 complexMcm10:pre-replicative complexDP-1:E2F complexAborted replication complexCyclin E/A:Cdk2:phospho-p27/p21ADPRb1:RNA primer-DNA primer:origin duplex with DNA damageATPADPCDKH2OADPMcm10:active pre-replicative complexp21/p27ATPRb-E2F:DP-1 complexCyclin E2:phospho-Cdk2 complexCdk4/6OrthophosphateWee1Cyclin EADPADPCyclin D:phospho-CDK4/6:p21/p27Cdc25ACyclin B:Cdk1 complexCdk4/6ubiquitinCyclin E:phospho-Cdk2 ComplexADPCyclin E1:Cdk2 complexphosphorylated Mcm2-7 complexSCF(Skp2):Cks1 complexATPINK4AMyt1 kinaseCdc45:CDK:DDK:Mcm10:pre-replicative complex26S proteasomep27Kip17, 82, 35461


Description

No description

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, Wright PE, Han J.; ''PRAK is essential for ras-induced senescence and tumor suppression.''; PubMed Europe PMC Scholia
  2. Chen CR, Kang Y, Siegel PM, Massagué J.; ''E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.''; PubMed Europe PMC Scholia
  3. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y.; ''Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.''; PubMed Europe PMC Scholia
  4. Derry JJ, Richard S, Valderrama Carvajal H, Ye X, Vasioukhin V, Cochrane AW, Chen T, Tyner AL.; ''Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.''; PubMed Europe PMC Scholia
  5. Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J.; ''Molecular interpretation of ERK signal duration by immediate early gene products.''; PubMed Europe PMC Scholia
  6. Guan KL, Jenkins CW, Li Y, O'Keefe CL, Noh S, Wu X, Zariwala M, Matera AG, Xiong Y.; ''Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.''; PubMed Europe PMC Scholia
  7. Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J.; ''Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.''; PubMed Europe PMC Scholia
  8. Watanabe N, Broome M, Hunter T.; ''Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.''; PubMed Europe PMC Scholia
  9. New L, Jiang Y, Han J.; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; PubMed Europe PMC Scholia
  10. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D.; ''The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.''; PubMed Europe PMC Scholia
  11. Glover JN, Harrison SC.; ''Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.''; PubMed Europe PMC Scholia
  12. Borriello A, Caldarelli I, Bencivenga D, Cucciolla V, Oliva A, Usala E, Danise P, Ronzoni L, Perrotta S, Della Ragione F.; ''p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells.''; PubMed Europe PMC Scholia
  13. Baek KH, Ryeom S.; ''Detection of Oncogene-Induced Senescence In Vivo.''; PubMed Europe PMC Scholia
  14. Hao B, Zheng N, Schulman BA, Wu G, Miller JJ, Pagano M, Pavletich NP.; ''Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.''; PubMed Europe PMC Scholia
  15. Zacksenhaus E, Bremner R, Phillips RA, Gallie BL.; ''A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.''; PubMed Europe PMC Scholia
  16. Blain SW, Montalvo E, Massagué J.; ''Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.''; PubMed Europe PMC Scholia
  17. Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.; ''CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.''; PubMed Europe PMC Scholia
  18. Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D.; ''Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.''; PubMed Europe PMC Scholia
  19. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.; ''Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.''; PubMed Europe PMC Scholia
  20. Sherr CJ, Roberts JM.; ''CDK inhibitors: positive and negative regulators of G1-phase progression.''; PubMed Europe PMC Scholia
  21. Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J.; ''Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.''; PubMed Europe PMC Scholia
  22. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K.; ''The retinoblastoma protein binds to a family of E2F transcription factors.''; PubMed Europe PMC Scholia
  23. Zou L, Stillman B.; ''Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.''; PubMed Europe PMC Scholia
  24. Zhang Y, Xiong Y, Yarbrough WG.; ''ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.''; PubMed Europe PMC Scholia
  25. Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T.; ''STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.''; PubMed Europe PMC Scholia
  26. Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK.; ''E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).''; PubMed Europe PMC Scholia
  27. Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC, Dutta A.; ''Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.''; PubMed Europe PMC Scholia
  28. Dou QP, Zhao S, Levin AH, Wang J, Helin K, Pardee AB.; ''G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.''; PubMed Europe PMC Scholia
  29. Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.; ''Regulation of CDK4.''; PubMed Europe PMC Scholia
  30. Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M.; ''Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.''; PubMed Europe PMC Scholia
  31. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J.; ''Chemokine signaling via the CXCR2 receptor reinforces senescence.''; PubMed Europe PMC Scholia
  32. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW.; ''Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.''; PubMed Europe PMC Scholia
  33. Takahashi A, Imai Y, Yamakoshi K, Kuninaka S, Ohtani N, Yoshimoto S, Hori S, Tachibana M, Anderton E, Takeuchi T, Shinkai Y, Peters G, Saya H, Hara E.; ''DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.''; PubMed Europe PMC Scholia
  34. Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D.; ''The subcellular localization of E2F-4 is cell-cycle dependent.''; PubMed Europe PMC Scholia
  35. Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M.; ''Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth.''; PubMed Europe PMC Scholia
  36. Lukong KE, Huot ME, Richard S.; ''BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.''; PubMed Europe PMC Scholia
  37. Hansen K, Farkas T, Lukas J, Holm K, Rönnstrand L, Bartek J.; ''Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.''; PubMed Europe PMC Scholia
  38. Jimi E, Ikebe T, Takahashi N, Hirata M, Suda T, Koga T.; ''Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells.''; PubMed Europe PMC Scholia
  39. Shen CH, Chen HY, Lin MS, Li FY, Chang CC, Kuo ML, Settleman J, Chen RH.; ''Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.''; PubMed Europe PMC Scholia
  40. Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD.; ''E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex.''; PubMed Europe PMC Scholia
  41. Magenta A, Fasanaro P, Romani S, Di Stefano V, Capogrossi MC, Martelli F.; ''Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation.''; PubMed Europe PMC Scholia
  42. Bagchi S, Weinmann R, Raychaudhuri P.; ''The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.''; PubMed Europe PMC Scholia
  43. Chittenden T, Livingston DM, Kaelin WG.; ''The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.''; PubMed Europe PMC Scholia
  44. Coulonval K, Bockstaele L, Paternot S, Dumont JE, Roger PP.; ''The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFbeta, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis.''; PubMed Europe PMC Scholia
  45. Blain SW.; ''Switching cyclin D-Cdk4 kinase activity on and off.''; PubMed Europe PMC Scholia
  46. Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, Meyer T.; ''Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1.''; PubMed Europe PMC Scholia
  47. Ostrander JH, Daniel AR, Lofgren K, Kleer CG, Lange CA.; ''Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.''; PubMed Europe PMC Scholia
  48. Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, Stacey KJ, Hume DA, Maki RA, Ostrowski MC.; ''Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.''; PubMed Europe PMC Scholia
  49. Bagui TK, Mohapatra S, Haura E, Pledger WJ.; ''P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes.''; PubMed Europe PMC Scholia
  50. Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP.; ''A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression.''; PubMed Europe PMC Scholia
  51. Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A.; ''Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.''; PubMed Europe PMC Scholia
  52. Gambus A, van Deursen F, Polychronopoulos D, Foltman M, Jones RC, Edmondson RD, Calzada A, Labib K.; ''A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.''; PubMed Europe PMC Scholia
  53. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS.; ''Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.''; PubMed Europe PMC Scholia
  54. Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.; ''Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.''; PubMed Europe PMC Scholia
  55. Yoshida K, Inoue I.; ''Regulation of Geminin and Cdt1 expression by E2F transcription factors.''; PubMed Europe PMC Scholia
  56. Meng W, Swenson LL, Fitzgibbon MJ, Hayakawa K, Ter Haar E, Behrens AE, Fulghum JR, Lippke JA.; ''Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.''; PubMed Europe PMC Scholia
  57. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC.; ''Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.''; PubMed Europe PMC Scholia
  58. Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy SF.; ''Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo.''; PubMed Europe PMC Scholia
  59. Shin I, Rotty J, Wu FY, Arteaga CL.; ''Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry.''; PubMed Europe PMC Scholia
  60. Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M.; ''Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.''; PubMed Europe PMC Scholia
  61. Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ.; ''MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.''; PubMed Europe PMC Scholia
  62. Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K.; ''Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1.''; PubMed Europe PMC Scholia
  63. Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA.; ''Regulated association of protein kinase B/Akt with breast tumor kinase.''; PubMed Europe PMC Scholia
  64. Kamalati T, Jolin HE, Fry MJ, Crompton MR.; ''Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation.''; PubMed Europe PMC Scholia
  65. Blomberg I, Hoffmann I.; ''Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.''; PubMed Europe PMC Scholia
  66. Jiang W, McDonald D, Hope TJ, Hunter T.; ''Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.''; PubMed Europe PMC Scholia
  67. Woo MS, Sánchez I, Dynlacht BD.; ''p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity.''; PubMed Europe PMC Scholia
  68. Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S, Grandér D.; ''Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence.''; PubMed Europe PMC Scholia
  69. Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM.; ''HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.''; PubMed Europe PMC Scholia
  70. Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P.; ''Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.''; PubMed Europe PMC Scholia
  71. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E.; ''New functional activities for the p21 family of CDK inhibitors.''; PubMed Europe PMC Scholia
  72. Giangrande PH, Zhu W, Rempel RE, Laakso N, Nevins JR.; ''Combinatorial gene control involving E2F and E Box family members.''; PubMed Europe PMC Scholia
  73. Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM.; ''Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.''; PubMed Europe PMC Scholia
  74. Meyerson M, Harlow E.; ''Identification of G1 kinase activity for cdk6, a novel cyclin D partner.''; PubMed Europe PMC Scholia
  75. Kang SA, Lee ST.; ''PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation.''; PubMed Europe PMC Scholia
  76. Serrano M, Hannon GJ, Beach D.; ''A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.''; PubMed Europe PMC Scholia
  77. Sugimoto M, Martin N, Wilks DP, Tamai K, Huot TJ, Pantoja C, Okumura K, Serrano M, Hara E.; ''Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1).''; PubMed Europe PMC Scholia
  78. Wotton D, Lo RS, Lee S, Massagué J.; ''A Smad transcriptional corepressor.''; PubMed Europe PMC Scholia
  79. Asano M, Wharton RP.; ''E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.''; PubMed Europe PMC Scholia
  80. Parry D, Bates S, Mann DJ, Peters G.; ''Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.''; PubMed Europe PMC Scholia
  81. Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J.; ''Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.''; PubMed Europe PMC Scholia
  82. Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH.; ''PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.''; PubMed Europe PMC Scholia
  83. Ohtani K, Nevins JR.; ''Functional properties of a Drosophila homolog of the E2F1 gene.''; PubMed Europe PMC Scholia
  84. To KH, Pajovic S, Gallie BL, Thériault BL.; ''Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.''; PubMed Europe PMC Scholia
  85. Ray A, James MK, Larochelle S, Fisher RP, Blain SW.; ''p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.''; PubMed Europe PMC Scholia
  86. Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, Lai PL, Shieh SY.; ''Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis.''; PubMed Europe PMC Scholia
  87. Sadasivam S, DeCaprio JA.; ''The DREAM complex: master coordinator of cell cycle-dependent gene expression.''; PubMed Europe PMC Scholia
  88. White A, Pargellis CA, Studts JM, Werneburg BG, Farmer BT.; ''Molecular basis of MAPK-activated protein kinase 2:p38 assembly.''; PubMed Europe PMC Scholia
  89. Depoortere F, Van Keymeulen A, Lukas J, Costagliola S, Bartkova J, Dumont JE, Bartek J, Roger PP, Dremier S.; ''A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes.''; PubMed Europe PMC Scholia
  90. Litovchick L, Florens LA, Swanson SK, Washburn MP, DeCaprio JA.; ''DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.''; PubMed Europe PMC Scholia
  91. Kang SA, Lee ES, Yoon HY, Randazzo PA, Lee ST.; ''PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1.''; PubMed Europe PMC Scholia
  92. Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL.; ''TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.''; PubMed Europe PMC Scholia
  93. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H.; ''Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.''; PubMed Europe PMC Scholia
  94. Malumbres M, Pérez De Castro I, Hernández MI, Jiménez M, Corral T, Pellicer A.; ''Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).''; PubMed Europe PMC Scholia
  95. Li YY, Wang L, Lu CD.; ''An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene.''; PubMed Europe PMC Scholia
  96. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S.; ''Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.''; PubMed Europe PMC Scholia
  97. Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW.; ''Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.''; PubMed Europe PMC Scholia
  98. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K.; ''Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.''; PubMed Europe PMC Scholia
  99. Narasimha AM, Kaulich M, Shapiro GS, Choi YJ, Sicinski P, Dowdy SF.; ''Cyclin D activates the Rb tumor suppressor by mono-phosphorylation.''; PubMed Europe PMC Scholia
  100. Hubscher U, Maga G, Spadari S.; ''Eukaryotic DNA polymerases.''; PubMed Europe PMC Scholia
  101. Paternot S, Roger PP.; ''Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation.''; PubMed Europe PMC Scholia
  102. Duronio RJ, O'Farrell PH.; ''Developmental control of a G1-S transcriptional program in Drosophila.''; PubMed Europe PMC Scholia
  103. Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG.; ''Catalysis and function of the p38 alpha.MK2a signaling complex.''; PubMed Europe PMC Scholia
  104. Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ.; ''Use of chromatin immunoprecipitation to clone novel E2F target promoters.''; PubMed Europe PMC Scholia
  105. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ.; ''The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.''; PubMed Europe PMC Scholia
  106. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS.; ''Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.''; PubMed Europe PMC Scholia
  107. Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AF, Hunton IC, Feramisco JR, Wang JY, Knudsen ES.; ''RB-dependent S-phase response to DNA damage.''; PubMed Europe PMC Scholia
  108. Wells JM, Illenye S, Magae J, Wu CL, Heintz NH.; ''Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition.''; PubMed Europe PMC Scholia
  109. Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR.; ''Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.''; PubMed Europe PMC Scholia
  110. Wang Z, Xie Y, Zhang L, Zhang H, An X, Wang T, Meng A.; ''Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.''; PubMed Europe PMC Scholia
  111. Brown VD, Phillips RA, Gallie BL.; ''Cumulative effect of phosphorylation of pRB on regulation of E2F activity.''; PubMed Europe PMC Scholia
  112. Kukimoto I, Igaki H, Kanda T.; ''Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.''; PubMed Europe PMC Scholia
  113. Haegebarth A, Heap D, Bie W, Derry JJ, Richard S, Tyner AL.; ''The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.''; PubMed Europe PMC Scholia
  114. Chakraborty G, Jain S, Kundu GC.; ''Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms.''; PubMed Europe PMC Scholia
  115. McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR.; ''Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.''; PubMed Europe PMC Scholia
  116. Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K.; ''Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".''; PubMed Europe PMC Scholia
  117. Bailly S, Fay M, Israël N, Gougerot-Pocidalo MA.; ''The transcription factor AP-1 binds to the human interleukin 1 alpha promoter.''; PubMed Europe PMC Scholia
  118. Fien K, Cho YS, Lee JK, Raychaudhuri S, Tappin I, Hurwitz J.; ''Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p.''; PubMed Europe PMC Scholia
  119. Furukawa Y, Terui Y, Sakoe K, Ohta M, Saito M.; ''The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells.''; PubMed Europe PMC Scholia
  120. Litovchick L, Sadasivam S, Florens L, Zhu X, Swanson SK, Velmurugan S, Chen R, Washburn MP, Liu XS, DeCaprio JA.; ''Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.''; PubMed Europe PMC Scholia
  121. Zhang Y, Baranovskiy AG, Tahirov TH, Pavlov YI.; ''The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex.''; PubMed Europe PMC Scholia
  122. Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG.; ''Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes.''; PubMed Europe PMC Scholia
  123. Jäkel H, Weinl C, Hengst L.; ''Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.''; PubMed Europe PMC Scholia
  124. Deacon K, Blank JL.; ''Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.''; PubMed Europe PMC Scholia
  125. Lukong KE, Richard S.; ''Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.''; PubMed Europe PMC Scholia
  126. Okazaki K, Sagata N.; ''The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.''; PubMed Europe PMC Scholia
  127. Sharpless NE, Sherr CJ.; ''Forging a signature of in vivo senescence.''; PubMed Europe PMC Scholia
  128. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J.; ''PRAK, a novel protein kinase regulated by the p38 MAP kinase.''; PubMed Europe PMC Scholia
  129. Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K, Roger PP.; ''Rb inactivation in cell cycle and cancer: the puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase.''; PubMed Europe PMC Scholia
  130. James MK, Ray A, Leznova D, Blain SW.; ''Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity.''; PubMed Europe PMC Scholia
  131. Zhu W, Giangrande PH, Nevins JR.; ''E2Fs link the control of G1/S and G2/M transcription.''; PubMed Europe PMC Scholia
  132. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S.; ''FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.''; PubMed Europe PMC Scholia
  133. Voges D, Zwickl P, Baumeister W.; ''The 26S proteasome: a molecular machine designed for controlled proteolysis.''; PubMed Europe PMC Scholia
  134. Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF.; ''RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity.''; PubMed Europe PMC Scholia
  135. Ainbinder E, Bergelson S, Pinkus R, Daniel V.; ''Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents.''; PubMed Europe PMC Scholia
  136. Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z.; ''Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.''; PubMed Europe PMC Scholia
  137. Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.; ''Brk is coamplified with ErbB2 to promote proliferation in breast cancer.''; PubMed Europe PMC Scholia
  138. Kamalati T, Jolin HE, Mitchell PJ, Barker KT, Jackson LE, Dean CJ, Page MJ, Gusterson BA, Crompton MR.; ''Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor.''; PubMed Europe PMC Scholia
  139. Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z.; ''Mdm2 association with p53 targets its ubiquitination.''; PubMed Europe PMC Scholia
  140. Quelle DE, Zindy F, Ashmun RA, Sherr CJ.; ''Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.''; PubMed Europe PMC Scholia
  141. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR.; ''Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.''; PubMed Europe PMC Scholia
  142. Mizukami Y, Yoshioka K, Morimoto S, Yoshida Ki.; ''A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.''; PubMed Europe PMC Scholia
  143. Foulds CE, Nelson ML, Blaszczak AG, Graves BJ.; ''Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.''; PubMed Europe PMC Scholia
  144. Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A.; ''The human homolog of Saccharomyces cerevisiae CDC45.''; PubMed Europe PMC Scholia
  145. Matsushime H, Ewen ME, Strom DK, Kato JY, Hanks SK, Roussel MF, Sherr CJ.; ''Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.''; PubMed Europe PMC Scholia
  146. Peng M, Ball-Kell SM, Tyner AL.; ''Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.''; PubMed Europe PMC Scholia
  147. Ohtani K, Tsujimoto A, Ikeda M, Nakamura M.; ''Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.''; PubMed Europe PMC Scholia
  148. Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC.; ''Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.''; PubMed Europe PMC Scholia
  149. Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain SW, Koff A.; ''Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.''; PubMed Europe PMC Scholia
  150. Zhang H.; ''Life without kinase: cyclin E promotes DNA replication licensing and beyond.''; PubMed Europe PMC Scholia
  151. Wu X, Bayle JH, Olson D, Levine AJ.; ''The p53-mdm-2 autoregulatory feedback loop.''; PubMed Europe PMC Scholia
  152. Liu N, Lucibello FC, Engeland K, Müller R.; ''A new model of cell cycle-regulated transcription: repression of the cyclin A promoter by CDF-1 and anti-repression by E2F.''; PubMed Europe PMC Scholia
  153. Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X.; ''B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.''; PubMed Europe PMC Scholia
  154. Kato JY, Matsuoka M, Strom DK, Sherr CJ.; ''Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.''; PubMed Europe PMC Scholia
  155. Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J.; ''A complex secretory program orchestrated by the inflammasome controls paracrine senescence.''; PubMed Europe PMC Scholia
  156. Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA.; ''Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.''; PubMed Europe PMC Scholia
  157. Ohtani K, DeGregori J, Nevins JR.; ''Regulation of the cyclin E gene by transcription factor E2F1.''; PubMed Europe PMC Scholia
  158. Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ.; ''A Code of Mono-phosphorylation Modulates the Function of RB.''; PubMed Europe PMC Scholia
  159. Bell SP, Dutta A.; ''DNA replication in eukaryotic cells.''; PubMed Europe PMC Scholia
  160. Seidel JJ, Graves BJ.; ''An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.''; PubMed Europe PMC Scholia
  161. Hannon GJ, Beach D.; ''p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.''; PubMed Europe PMC Scholia
  162. Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R, Livingston DM.; ''Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.''; PubMed Europe PMC Scholia
  163. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T, Akira S.; ''Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.''; PubMed Europe PMC Scholia
  164. Arata Y, Fujita M, Ohtani K, Kijima S, Kato JY.; ''Cdk2-dependent and -independent pathways in E2F-mediated S phase induction.''; PubMed Europe PMC Scholia
  165. Dhar SK, Delmolino L, Dutta A.; ''Architecture of the human origin recognition complex.''; PubMed Europe PMC Scholia
  166. Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H.; ''A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.''; PubMed Europe PMC Scholia
  167. Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K.; ''Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.''; PubMed Europe PMC Scholia
  168. Tsvetkov LM, Yeh KH, Lee SJ, Sun H, Zhang H.; ''p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27.''; PubMed Europe PMC Scholia
  169. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM.; ''Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.''; PubMed Europe PMC Scholia
  170. Fan G, Aleem S, Yang M, Miller WT, Tonks NK.; ''Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.''; PubMed Europe PMC Scholia
  171. Vashee S, Simancek P, Challberg MD, Kelly TJ.; ''Assembly of the human origin recognition complex.''; PubMed Europe PMC Scholia
  172. Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ.; ''Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.''; PubMed Europe PMC Scholia
  173. Desai D, Wessling HC, Fisher RP, Morgan DO.; ''Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.''; PubMed Europe PMC Scholia
  174. Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H.; ''Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.''; PubMed Europe PMC Scholia
  175. Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y.; ''Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.''; PubMed Europe PMC Scholia
  176. Connell-Crowley L, Harper JW, Goodrich DW.; ''Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.''; PubMed Europe PMC Scholia
  177. Li Y, Asahara H, Patel VS, Zhou S, Linn S.; ''Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon.''; PubMed Europe PMC Scholia
  178. Wang W, Nacusi L, Sheaff RJ, Liu X.; ''Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.''; PubMed Europe PMC Scholia
  179. Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC.; ''Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.''; PubMed Europe PMC Scholia
  180. Liu S, Bolger JK, Kirkland LO, Premnath PN, McInnes C.; ''Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.''; PubMed Europe PMC Scholia
  181. Parisi T, Pollice A, Di Cristofano A, Calabrò V, La Mantia G.; ''Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.''; PubMed Europe PMC Scholia
  182. Hartupee J, Li X, Hamilton T.; ''Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1.''; PubMed Europe PMC Scholia
  183. Atwood AA, Sealy LJ.; ''C/EBPβ's role in determining Ras-induced senescence or transformation.''; PubMed Europe PMC Scholia
  184. Patel P, Asbach B, Shteyn E, Gomez C, Coltoff A, Bhuyan S, Tyner AL, Wagner R, Blain SW.; ''Brk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4.''; PubMed Europe PMC Scholia
  185. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J.; ''Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.''; PubMed Europe PMC Scholia
  186. Ishida N, Kitagawa M, Hatakeyama S, Nakayama K.; ''Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.''; PubMed Europe PMC Scholia
  187. Kato JY, Matsuoka M, Polyak K, Massagué J, Sherr CJ.; ''Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.''; PubMed Europe PMC Scholia
  188. Carrano AC, Eytan E, Hershko A, Pagano M.; ''SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.''; PubMed Europe PMC Scholia
  189. Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L.; ''Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.''; PubMed Europe PMC Scholia
  190. Beijersbergen RL, Carlée L, Kerkhoven RM, Bernards R.; ''Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.''; PubMed Europe PMC Scholia
  191. Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F.; ''The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.''; PubMed Europe PMC Scholia
  192. Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, Kubben N, Holzer B, Ludwig S, Rapp UR.; ''MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.''; PubMed Europe PMC Scholia
  193. Sithanandam G, Latif F, Duh FM, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S.; ''3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.''; PubMed Europe PMC Scholia
  194. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K.; ''The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.''; PubMed Europe PMC Scholia
  195. Young AR, Narita M.; ''SASP reflects senescence.''; PubMed Europe PMC Scholia
  196. Bockstaele L, Bisteau X, Paternot S, Roger PP.; ''Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.''; PubMed Europe PMC Scholia
  197. Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G.; ''Mitochondrial dysfunction contributes to oncogene-induced senescence.''; PubMed Europe PMC Scholia
  198. Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G.; ''ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression.''; PubMed Europe PMC Scholia
  199. Chattopadhyay S, Bielinsky AK.; ''Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.''; PubMed Europe PMC Scholia
  200. Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D.; ''PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.''; PubMed Europe PMC Scholia
  201. Ou L, Ferreira AM, Otieno S, Xiao L, Bashford D, Kriwacki RW.; ''Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.''; PubMed Europe PMC Scholia
  202. Tanizaki J, Okamoto I, Sakai K, Nakagawa K.; ''Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification.''; PubMed Europe PMC Scholia
  203. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR.; ''The E2F transcription factor is a cellular target for the RB protein.''; PubMed Europe PMC Scholia
  204. Kelly BL, Wolfe KG, Roberts JM.; ''Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.''; PubMed Europe PMC Scholia
  205. Niehof M, Streetz K, Rakemann T, Bischoff SC, Manns MP, Horn F, Trautwein C.; ''Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.''; PubMed Europe PMC Scholia
  206. Lukong KE, Larocque D, Tyner AL, Richard S.; ''Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.''; PubMed Europe PMC Scholia
  207. Cheng M, Sexl V, Sherr CJ, Roussel MF.; ''Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).''; PubMed Europe PMC Scholia
  208. Atwood AA, Sealy L.; ''Regulation of C/EBPbeta1 by Ras in mammary epithelial cells and the role of C/EBPbeta1 in oncogene-induced senescence.''; PubMed Europe PMC Scholia
  209. Jiang W, Wells NJ, Hunter T.; ''Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.''; PubMed Europe PMC Scholia
  210. Leng X, Noble M, Adams PD, Qin J, Harper JW.; ''Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.''; PubMed Europe PMC Scholia
  211. Zheng Y, Asara JM, Tyner AL.; ''Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate.''; PubMed Europe PMC Scholia
  212. Orend G, Hunter T, Ruoslahti E.; ''Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.''; PubMed Europe PMC Scholia
  213. Bagui TK, Jackson RJ, Agrawal D, Pledger WJ.; ''Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).''; PubMed Europe PMC Scholia
  214. Tedesco D, Lukas J, Reed SI.; ''The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2).''; PubMed Europe PMC Scholia
  215. Yu B, Lane ME, Pestell RG, Albanese C, Wadler S.; ''Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein.''; PubMed Europe PMC Scholia
  216. Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K.; ''The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.''; PubMed Europe PMC Scholia
  217. Ono H, Basson MD, Ito H.; ''PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.''; PubMed Europe PMC Scholia
  218. Reynisdóttir I, Massagué J.; ''The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.''; PubMed Europe PMC Scholia
  219. Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH.; ''Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.''; PubMed Europe PMC Scholia
  220. Castro NE, Lange CA.; ''Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.''; PubMed Europe PMC Scholia
  221. Lundberg AS, Weinberg RA.; ''Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes.''; PubMed Europe PMC Scholia
  222. Bertoli C, Klier S, McGowan C, Wittenberg C, de Bruin RA.; ''Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription.''; PubMed Europe PMC Scholia
  223. Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K.; ''EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.''; PubMed Europe PMC Scholia
  224. Galaktionov K, Chen X, Beach D.; ''Cdc25 cell-cycle phosphatase as a target of c-myc.''; PubMed Europe PMC Scholia
  225. DeGregori J, Kowalik T, Nevins JR.; ''Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.''; PubMed Europe PMC Scholia
  226. Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR.; ''Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor.''; PubMed Europe PMC Scholia
  227. Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K.; ''CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase.''; PubMed Europe PMC Scholia
  228. Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J.; ''p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.''; PubMed Europe PMC Scholia
  229. Hiebert SW.; ''Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.''; PubMed Europe PMC Scholia
  230. Goel RK, Lukong KE.; ''Tracing the footprints of the breast cancer oncogene BRK - Past till present.''; PubMed Europe PMC Scholia
  231. Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E.; ''Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.''; PubMed Europe PMC Scholia
  232. Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.; ''Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.''; PubMed Europe PMC Scholia
  233. Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.''; PubMed Europe PMC Scholia
  234. Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.; ''Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.''; PubMed Europe PMC Scholia
  235. Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL.; ''Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.''; PubMed Europe PMC Scholia
  236. Chen HY, Shen CH, Tsai YT, Lin FC, Huang YP, Chen RH.; ''Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin.''; PubMed Europe PMC Scholia
  237. Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A.; ''The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.''; PubMed Europe PMC Scholia
  238. Vidal A, Koff A.; ''Cell-cycle inhibitors: three families united by a common cause.''; PubMed Europe PMC Scholia
  239. Walter J, Newport J.; ''Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha.''; PubMed Europe PMC Scholia
  240. Li Y, Pursell ZF, Linn S.; ''Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.''; PubMed Europe PMC Scholia
  241. Clifton AD, Young PR, Cohen P.; ''A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.''; PubMed Europe PMC Scholia
  242. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P.; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; PubMed Europe PMC Scholia
  243. Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M.; ''Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.''; PubMed Europe PMC Scholia
  244. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G.; ''The E2F1-3 transcription factors are essential for cellular proliferation.''; PubMed Europe PMC Scholia
  245. Vijayachandra K, Lee J, Glick AB.; ''Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.''; PubMed Europe PMC Scholia
  246. Gao Y, Cimica V, Reich NC.; ''Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.''; PubMed Europe PMC Scholia
  247. Takekawa M, Tatebayashi K, Saito H.; ''Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.''; PubMed Europe PMC Scholia
  248. Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G.; ''DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.''; PubMed Europe PMC Scholia
  249. Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y.; ''pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.''; PubMed Europe PMC Scholia
  250. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M.; ''p16(INK4a) translation suppressed by miR-24.''; PubMed Europe PMC Scholia
  251. Kardinal C, Dangers M, Kardinal A, Koch A, Brandt DT, Tamura T, Welte K.; ''Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.''; PubMed Europe PMC Scholia
  252. Cobrinik D.; ''Pocket proteins and cell cycle control.''; PubMed Europe PMC Scholia
  253. Fan G, Lin G, Lucito R, Tonks NK.; ''Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.''; PubMed Europe PMC Scholia
  254. Aprelikova O, Xiong Y, Liu ET.; ''Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.''; PubMed Europe PMC Scholia
  255. Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ.; ''ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
114646view16:11, 25 January 2021ReactomeTeamReactome version 75
113094view11:15, 2 November 2020ReactomeTeamReactome version 74
112328view15:25, 9 October 2020ReactomeTeamReactome version 73
112225view14:39, 2 October 2020DeSlOntology Term : 'M/G1 transition pathway' added !
101227view11:12, 1 November 2018ReactomeTeamreactome version 66
100765view20:38, 31 October 2018ReactomeTeamreactome version 65
100309view19:15, 31 October 2018ReactomeTeamreactome version 64
99855view15:59, 31 October 2018ReactomeTeamreactome version 63
99413view14:35, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93757view13:34, 16 August 2017ReactomeTeamreactome version 61
93279view11:19, 9 August 2017ReactomeTeamreactome version 61
86357view09:16, 11 July 2016ReactomeTeamreactome version 56
83315view10:46, 18 November 2015ReactomeTeamVersion54
81454view12:59, 21 August 2015ReactomeTeamVersion53
76928view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76633view12:00, 16 July 2014ReactomeTeamFixed remaining interactions
76130view12:48, 11 June 2014Anwesha
76129view12:44, 11 June 2014ReactomeTeamAdding missing reactome URL
75666view10:57, 10 June 2014ReactomeTeamReactome 48 Update
75021view13:53, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74665view08:43, 30 April 2014ReactomeTeamReactome46
68884view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
44912view10:35, 6 October 2011MartijnVanIerselOntology Term : 'cell cycle pathway, mitotic' added !
42076view21:55, 4 March 2011MaintBotAutomatic update
39884view05:54, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
26S

proteasome

ComplexREACT_7467 (Reactome)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Aborted replication

complex

ComplexREACT_2817 (Reactome)
CAK ComplexREACT_5717 (Reactome)
CDK ComplexREACT_5476 (Reactome)
CDK:DDK:Mcm10:

pre-replicative complex

ComplexREACT_2458 (Reactome)
CDT1 ProteinQ9H211 (UniProt)
Cdc25A ProteinP30304 (UniProt)
Cdc45 ProteinO75419 (UniProt)
Cdc45:CDK:DDK:

Mcm10:pre- replicative complex

ComplexREACT_4546 (Reactome)
Cdk2 ProteinP24941 (UniProt)
Cdk4/6 UnknownREACT_4552 (Reactome)
Cdk4/6 ProteinREACT_8720 (Reactome)
Cdk4/6:INK4A complex ComplexREACT_8076 (Reactome)
Cks1 ProteinP61024 (UniProt)
Cyclin B:Cdk1

complex

ComplexREACT_4583 (Reactome)
Cyclin D ProteinREACT_8063 (Reactome)
Cyclin D:CDK4/6:

p21/p27 complex

ComplexREACT_2341 (Reactome)
Cyclin D:Cdk4/6:

p21/p27

ComplexREACT_2453 (Reactome)
Cyclin D:phospho-

CDK4/6:p21/p27

ComplexREACT_3625 (Reactome)
Cyclin E ProteinREACT_5284 (Reactome)
Cyclin E/A:

Cdk2:phospho- p27/p21

ComplexREACT_9321 (Reactome)
Cyclin E/A:Cdk2 ComplexREACT_9091 (Reactome)
Cyclin E/A:Cdk2:

multiubiquitinated phospho-p27/p21: SCF(Skp2):Cks1 complex

ComplexREACT_9266 (Reactome)
Cyclin E/A:Cdk2:

p27/p21 complex

ComplexREACT_9314 (Reactome)
Cyclin E/A:Cdk2:

phospho-p27/p21: SCF(Skp2):Cks1 complex

ComplexREACT_9193 (Reactome)
Cyclin E1:Cdk2

complex

ComplexREACT_4601 (Reactome)
Cyclin E1:phospho-

Cdk2 complex

ComplexREACT_2714 (Reactome)
Cyclin E2:Cdk2

complex

ComplexREACT_5296 (Reactome)
Cyclin E2:phospho-

Cdk2 complex

ComplexREACT_3967 (Reactome)
Cyclin E:Cdk2

complexes

ComplexREACT_5247 (Reactome)
Cyclin E:Cdk2 complex ComplexREACT_3296 (Reactome)
Cyclin E:Cdk2:

p21/p27 complex

ComplexREACT_3804 (Reactome)
Cyclin E:Phosho-

Cdk2 (Thr 160)

ComplexREACT_9167 (Reactome)
Cyclin E:Phospho-

Cdk2(Thr160):Rb complex

ComplexREACT_9136 (Reactome)
Cyclin E:phospho-

Cdk2 (Thr 160): phospho-Rb

ComplexREACT_9190 (Reactome)
Cyclin E:phospho-

Cdk2 Complex

ComplexREACT_4112 (Reactome)
DDK ComplexREACT_4813 (Reactome)
DNA Replication Factor

A

ComplexREACT_5149 (Reactome)
DNA polymerase

alpha:primase

ComplexREACT_3725 (Reactome)
DNA polymerase

alpha:primase:DNA polymerase alpha: origin complex

ComplexREACT_3167 (Reactome)
DNA polymerase

epsilon

ComplexREACT_4621 (Reactome)
DNA polymerase

epsilon:origin complex

ComplexREACT_3283 (Reactome)
DP-1:E2F

complex

ComplexREACT_2896 (Reactome)
DP-1:E2F1 complex ComplexREACT_5400 (Reactome)
E2F1 targets ProteinREACT_22550 (Reactome)
H2O Metabolite15377 (ChEBI)
INK4A UnknownREACT_8915 (Reactome)
Mcm10 ProteinQ7L590 (UniProt)
Mcm10:active

pre-replicative complex

ComplexREACT_2683 (Reactome)
Mcm10:pre-

replicative complex

ComplexREACT_5685 (Reactome)
Mcm2-7

complex

ComplexREACT_4763 (Reactome)
Myc/Max

heterodimer

ComplexREACT_9233 (Reactome)
Myt1 kinase ProteinQ99640 (UniProt)
ORC:origin ComplexREACT_3844 (Reactome)
ORC:origin:cyclin B:

cdk1 complex

ComplexREACT_4235 (Reactome)
Orthophosphate Metabolite18367 (ChEBI)
PP2A UnknownREACT_5265 (Reactome)
RNA primer-DNA

primer:origin duplex

ComplexREACT_5497 (Reactome)
RNA primer-DNA

primer:origin duplex with DNA damage

ComplexREACT_2843 (Reactome)
RPA:Cdc45:CDK:DDK:

Mcm10:pre- replicative complex

ComplexREACT_2568 (Reactome)
Rb-E2F:DP-1

complex

ComplexREACT_4483 (Reactome)
Rb1:RNA primer-DNA

primer:origin duplex with DNA damage

ComplexREACT_3869 (Reactome)
Retinoblastoma

Protein 1

ProteinP06400 (UniProt)
SCF(Skp2) complex ComplexREACT_9339 (Reactome)
SCF(Skp2):Cks1

complex

ComplexREACT_9182 (Reactome)
Wee1 ProteinP30291 (UniProt)
origin of

replication

UnknownREACT_3087 (Reactome)
p21 ProteinP38936 (UniProt)
p21/p27 ProteinREACT_8233 (Reactome)
p21/p27 ProteinREACT_8306 (Reactome)
p27 ProteinP46527 (UniProt)
p27Kip1 ProteinP46527 (UniProt)
phospho-

Retinoblastoma protein

ProteinP06400 (UniProt)
phosphorylated

Mcm2-7 complex

ComplexREACT_4259 (Reactome)
pre-replicative

complex

ComplexREACT_4388 (Reactome)
ubiquitin ProteinREACT_3995 (Reactome)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1858"
Personal tools