Serotonin receptor 2 and ELK-SRF/GATA4 signaling (Homo sapiens)
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- Nebigil CG, Etienne N, Messaddeq N, Maroteaux L; ''Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.''; FASEB J, 2003 PubMed Europe PMC Scholia
- Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
- Nonner D, Barrett EF, Barrett JN; ''Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons.''; J Neurochem, 2000 PubMed Europe PMC Scholia
- Mochizuki N, Ohba Y, Kobayashi S, Otsuka N, Graybiel AM, Tanaka S, Matsuda M; ''Crk activation of JNK via C3G and R-Ras.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
- Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, Han J, Drugan JK, Broek D, Campbell SL, Der CJ; ''Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
- Suttles J, Milhorn DM, Miller RW, Poe JC, Wahl LM, Stout RD; ''CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
- Li QJ, Vaingankar S, Sladek FM, Martins-Green M; ''Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.''; Blood, 2000 PubMed Europe PMC Scholia
- Felix JA, Chaban VV, Woodruff ML, Dirksen ER; ''Mechanical stimulation initiates intercellular Ca2+ signaling in intact tracheal epithelium maintained under normal gravity and simulated microgravity.''; Am J Respir Cell Mol Biol, 1998 PubMed Europe PMC Scholia
- Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
- Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC Scholia
- Jacquet E, Vanoni M, Ferrari C, Alberghina L, Martegani E, Parmeggiani A; ''A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
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- LaVoie HA; ''The role of GATA in mammalian reproduction.''; Exp Biol Med (Maywood), 2003 PubMed Europe PMC Scholia
- Nitsch RM, Deng M, Growdon JH, Wurtman RJ; ''Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
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- Ravanti L, Heino J, Lأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½pez-Otأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½n C, Kأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½hأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
- Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH; ''Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC Scholia
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- Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR; ''Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
- Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D'Souza DN, Garcia F, Battaglia G, Muma NA; ''Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
- Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
- Buchsbaum R, Telliez JB, Goonesekera S, Feig LA; ''The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium.''; Mol Cell Biol, 1996 PubMed Europe PMC Scholia
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- Bأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC Scholia
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- Pikkarainen S, Tokola H, Kerkelأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H; ''Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
- Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC Scholia
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- Enarsson M, Erlandsson A, Larsson H, Forsberg-Nilsson K; ''Extracellular signal-regulated protein kinase signaling is uncoupled from initial differentiation of central nervous system stem cells to neurons.''; Mol Cancer Res, 2002 PubMed Europe PMC Scholia
- Deszo EL, Brake DK, Cengel KA, Kelley KW, Freund GG; ''CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
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- Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC Scholia
- Dougalis A, Lees G, Ganellin CR; ''The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro.''; Neuropharmacology, 2004 PubMed Europe PMC Scholia
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- Schoenbaum G, Chiba AA, Gallagher M; ''Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning.''; J Neurosci, 1999 PubMed Europe PMC Scholia
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
1,4,5-Insp3 | Metabolite | 85166-31-0 (CAS) | 1,4,5-Insp3 |
CALCIUM | Metabolite | 7440-70-2 (CAS) | |
ELK1 | GeneProduct | 2002 (Entrez Gene) | ELK1, member of ETS oncogene family |
ELK4 | GeneProduct | 2005 (Entrez Gene) | ETS domain-containing protein Elk-4 (SRF accessory protein 1) |
GATA4 | GeneProduct | 2626 (Entrez Gene) | GATA-binding protein 4/5/6 |
GNAQ | GeneProduct | 2776 (Entrez Gene) | guanine nucleotide binding protein, alpha q polypeptide |
HTR2A | GeneProduct | 3356 (Entrez Gene) | 5-hydroxytryptamine (serotonin) receptor 2A |
HTR2B | GeneProduct | 3357 (Entrez Gene) | 5-hydroxytryptamine (serotonin) receptor 2B |
HTR2C | GeneProduct | 3358 (Entrez Gene) | 5-hydroxytryptamine (serotonin) receptor 2C |
ITPR1 | GeneProduct | 3708 (Entrez Gene) | inositol 1,4,5-triphosphate receptor 1 |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | mitogen activated protein kinase kinase 1 |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | mitogen activated protein kinase kinase 2 |
MAPK1 | GeneProduct | 6871 (HUGO) | mitogen activated protein kinase 1 |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | mitogen activated protein kinase 3 |
MAPKAPK2 | GeneProduct | 9261 (Entrez Gene) | MAP kinase-activated protein kinase 2 |
PLC | Protein | phospholipase C group | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | v-raf-leukemia viral oncogene 1 |
RASGRF1 | GeneProduct | 5923 (Entrez Gene) | RAS protein-specific guanine nucleotide-releasing factor 1 |
RASGRP1 | GeneProduct | 10125 (Entrez Gene) | RAS guanyl releasing protein 1 |
Ras | Protein | RAS oncogene homolog group | |
SRF | GeneProduct | 6722 (Entrez Gene) | serum response factor |
serotonin | Metabolite | 50-67-9 (CAS) |
Annotated Interactions
No annotated interactions