Cell cycle (Homo sapiens)

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1(Start)+p+pTranscription Factor E2FDNAp21proteolysis+p+pSpathwaye+p+u+pGrowth Factor+p+u+p-p+u+pp16,15,18,19+pORC (OriginRecognition complex)+pMAPKCondensinmediated+p+usignalingM+p+p+pHistone DeacetylasesG2ApoptosisS-phase proteinsp27,57HDAC+u-pMCM (Mini-ChromosomeMaintenance) complexDNA damage checkpointUbiquitinSeparinDNA biosynthesisGrowth Factor withdrawalDNAeG1+peeeSecurin+pR-pointHDAC5APC/CRBL1RBL1CDC25CORC6LUBE2FCCNB3E2F2MCM3CDC45LE2FGADD45AMAD2L1PRKDCPKMYT1CDC7MCM6TP53EP300WEE1ESPL1E2F4CDKN1BCHEK2HDAC8MCM5MCM7CDC2CDH1YWHAGE2F1ORC4LCDC14AHDAC7AORC3LCCNB2ORC2LARF1CDC14BCDC20CCND2RB1HDAC4ASKHDAC2BUB1HDAC1MDM2MCM4PLK1MCMABL1ATRTFDP1E2F5CCNA1ORCCDKN2ACCND3SMC1L1CDC2ORC1LMPEG1CDK2MCM2SKP2BUB1BTGFB1CDC6HDAC3ATMCHEK1RB1CCNA2CDK6SCFCDK2SCFGSK3BCDK2PTTG2CDC25BCCNHSMAD3MENGeneProductPCNACCNA1CDK4ORC5LCCNE1HDAC6YWHAGSKP2APC/CBUB3CDKN1APTTG3RB1CDC25ACCNE2E2F3CCNA2MAD2L2TBC1D8E2F6CCNB1PTTG1MAD1L1SMAD4YWHABYWHAEYWHAHYWHAQYWHAZ


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html

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Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127277view15:52, 1 September 2023Khanspersfixed phospho site
127262view04:52, 30 August 2023Khanspersadded phospho sites
127255view18:16, 28 August 2023Khanspersadded lliterature reference and updated description
127172view06:20, 9 August 2023Fehrhartbox for pathway
127158view23:32, 7 August 2023Khanspersupdated ptms
122978view19:12, 8 June 2022Mkutmonfix unconnected pathway node
122977view19:09, 8 June 2022Mkutmonremoved empty groups
120742view23:40, 27 December 2021EweitzRefine graphics, text; use gene symbols
120027view22:50, 15 October 2021Khanspersupdate phosphosites
120026view20:26, 15 October 2021Khanspersupdate phosphosites
120025view20:12, 15 October 2021Khanspersupdate phosphosites
120024view19:57, 15 October 2021Khanspersupdated phosphosites
116693view15:31, 9 May 2021EweitzModified title
114261view13:57, 2 January 2021EgonwThree more pathways clickable
112039view17:58, 16 September 2020Khanspersupdated phospho site
106351view21:36, 21 August 2019KhanspersModified description
105448view04:58, 8 August 2019KhanspersModified description
105235view13:42, 23 July 2019EgonwNo gene-gene conversion.
103430view16:00, 28 February 2019DeSlRemoved last modified item
97174view17:12, 3 May 2018AlexanderPicochanged complex to paralog group
96994view21:13, 25 April 2018Khanspersadded phosphosites
96993view20:19, 25 April 2018Khanspersinteractions and phosphosites
96985view05:19, 25 April 2018Khanspersoverhaul: updated to Ensembl, added phoshposites, complexes etc
96984view01:20, 25 April 2018Khanspersoverhaul in progress
96983view23:29, 24 April 2018Khanspersoverhaul in progress
93002view18:31, 21 July 2017KhanspersReverted to version '10:59, 16 September 2016' by Khanspers
92878view08:44, 13 July 2017JosipMadunicCell Cycle
89516view10:59, 16 September 2016Mkutmonontology tag fix
89470view13:39, 15 September 2016Mkutmonremove space from ontology term id
70629view00:22, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
69900view19:28, 11 July 2013AlexanderPicoModified title
67101view10:06, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
63158view20:18, 8 May 2013MaintBotUpdating gpml version
59175view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45137view00:58, 7 October 2011AlexanderPico
45136view00:57, 7 October 2011AlexanderPicoModified description
45135view00:56, 7 October 2011AlexanderPicoModified description
45134view00:56, 7 October 2011AlexanderPicoModified description
45133view00:55, 7 October 2011AlexanderPicoModified description
45089view21:00, 6 October 2011AlexanderPico
45087view20:58, 6 October 2011AlexanderPicodb refs
45084view20:51, 6 October 2011AlexanderPicofixed pathway refs
45079view20:41, 6 October 2011AlexanderPicoadded groups
45075view20:31, 6 October 2011AlexanderPicoadded groups and db refs
45071view20:14, 6 October 2011AlexanderPicoadded db ref and group
41134view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
35361view09:11, 12 February 2010MartijnVanIerselModified description
34663view12:07, 8 January 2010ThomasReverted color change of gene boxes by BadrulYahaya (no meaning for the color provided)
32357view13:40, 15 August 2009MaintBotFixed text labels
31988view13:13, 14 August 2009MaintBotFixed group labels

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/CGeneProduct
ARF1GeneProductENSG00000143761 (Ensembl Human)
ASKGeneProduct10926 (Entrez Gene) ASK; activator of S phase kinas
ATMGeneProduct472 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProductA1AU HUMAN (SwissProt) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProduct699 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct701 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct9184 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct8900 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct890 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProduct891 (Entrez Gene) CCNB1; cyclin B1
CCNB2GeneProduct9133 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProduct85417 (Entrez Gene) CCNB3; cyclin B
CCND2GeneProduct894 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct896 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct898 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct9134 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct902 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct8556 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14BGeneProduct8555 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct991 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC25AGeneProduct993 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25BGeneProduct994 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25CGeneProduct995 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC2GeneProduct983 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC45LGeneProduct8318 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct990 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct8317 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct999 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct1019 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct1021 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct11200 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
E2FGeneProduct
E2F1GeneProduct1869 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProduct1870 (Entrez Gene) E2F2; E2F transcription factor 2
E2F3GeneProduct1871 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct1874 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProduct1875 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F6GeneProduct1876 (Entrez Gene) E2F6; E2F transcription factor 6
EP300GeneProduct2033 (Entrez Gene) EP300; E1A binding protein p300
ESPL1GeneProduct9700 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct1647 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProductGeneProduct
HDAC1GeneProduct3065 (Entrez Gene) HDAC1; histone deacetylase 1
HDAC2GeneProduct3066 (Entrez Gene) HDAC2; histone deacetylase 2
HDAC3GeneProduct8841 (Entrez Gene) HDAC3; histone deacetylase 3
HDAC4GeneProduct9759 (Entrez Gene) HDAC4; histone deacetylase 4
HDAC5GeneProduct10014 (Entrez Gene) HDAC5; histone deacetylase 5
HDAC6GeneProduct10013 (Entrez Gene) HDAC6; histone deacetylase 6
HDAC7AGeneProduct51564 (Entrez Gene) HDAC7A; histone deacetylase 7
HDAC8GeneProduct55869 (Entrez Gene) HDAC8; histone deacetylase
MAD1L1GeneProduct8379 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct4085 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct10459 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MCM2GeneProduct4171 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct4172 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct4173 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct4174 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct4175 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProduct4176 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct4193 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct
MPEG1GeneProduct219972 (Entrez Gene)
ORCGeneProduct
ORC1LGeneProduct4998 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct4999 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct23595 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct5000 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct5001 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct23594 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct5111 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProduct9088 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct5347 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct5591 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct9232 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProduct10744 (Entrez Gene) PTTG2; pituitary tumor-transforming
PTTG3GeneProduct26255 (Entrez Gene) PTTG3; pituitary tumor-transforming
RB1GeneProduct5925 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct5933 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SCFGeneProduct
SCFProteinP21583 (Uniprot/TrEMBL)
SKP2GeneProduct6502 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct4088 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct4089 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1L1GeneProduct8243 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct11138 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct7040 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
UBE2FGeneProduct23665 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct7465 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHABGeneProductENSG00000166913 (Ensembl Human)
YWHAEGeneProductENSG00000108953 (Ensembl Human)
YWHAGGeneProduct7532 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
YWHAGGeneProductENSG00000170027 (Ensembl Human)
YWHAHGeneProductENSG00000128245 (Ensembl Human)
YWHAQGeneProductENSG00000134308 (Ensembl Human)
YWHAZGeneProductENSG00000164924 (Ensembl Human)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP179"
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