This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.
Source: KEGG (http://www.genome.jp/kegg/pathway/hsa/hsa05010.html)
Papagiannakopoulos T, Shapiro A, Kosik KS; ''MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.''; Cancer Res, 2008 PubMedEurope PMCScholia
Vargas LM, Cerpa W, Muñoz FJ, Zanlungo S, Alvarez AR; ''Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.''; Biochim Biophys Acta Mol Basis Dis, 2018 PubMedEurope PMCScholia
Wasser CR, Herz J; ''Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.''; J Biol Chem, 2017 PubMedEurope PMCScholia
Lane-Donovan C, Herz J; ''ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.''; Trends Endocrinol Metab, 2017 PubMedEurope PMCScholia
Mattson MP; ''Pathways towards and away from Alzheimer's disease.''; Nature, 2004 PubMedEurope PMCScholia
Wu H, Huang M, Lu M, Zhu W, Shu Y, Cao P, Liu P; ''Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel.''; Cancer Chemother Pharmacol, 2013 PubMedEurope PMCScholia
Shen Y, He P, Zhong Z, McAllister C, Lindholm K; ''Distinct destructive signal pathways of neuronal death in Alzheimer's disease.''; Trends Mol Med, 2006 PubMedEurope PMCScholia
Sushma, Mondal AC; ''Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.''; Mol Cell Neurosci, 2019 PubMedEurope PMCScholia
Bezprozvanny I, Mattson MP; ''Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.''; Trends Neurosci, 2008 PubMedEurope PMCScholia
Terao M, Fratelli M, Kurosaki M, Zanetti A, Guarnaccia V, Paroni G, Tsykin A, Lupi M, Gianni M, Goodall GJ, Garattini E; ''Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets.''; J Biol Chem, 2011 PubMedEurope PMCScholia
Hölscher C; ''Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.''; Neurobiol Dis, 1998 PubMedEurope PMCScholia
Vallée A, Lecarpentier Y; ''Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.''; Front Neurosci, 2016 PubMedEurope PMCScholia
Chan XH, Nama S, Gopal F, Rizk P, Ramasamy S, Sundaram G, Ow GS, Ivshina AV, Tanavde V, Haybaeck J, Kuznetsov V, Sampath P; ''Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas.''; Cell Rep, 2012 PubMedEurope PMCScholia
Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T, Shill H, Adler C, Sabbagh M, Villa S, Tembe W, Craig D, Van Keuren-Jensen K; ''Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology.''; PLoS One, 2014 PubMedEurope PMCScholia
Popugaeva E, Pchitskaya E, Bezprozvanny I; ''Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.''; Antioxid Redox Signal, 2018 PubMedEurope PMCScholia
Ivins KJ, Thornton PL, Rohn TT, Cotman CW; ''Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.''; Neurobiol Dis, 1999 PubMedEurope PMCScholia
Tian S, Huang S, Wu S, Guo W, Li J, He X; ''MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region.''; Biochem Biophys Res Commun, 2010 PubMedEurope PMCScholia
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A; ''Presenilin-mediated signal transduction.''; Physiol Behav, 2007 PubMedEurope PMCScholia
Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G; ''Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.''; Aging Cell, 2008 PubMedEurope PMCScholia
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE; ''Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.''; Exp Gerontol, 2006 PubMedEurope PMCScholia
Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, Wang B, Wang G, Jia Z, Pu P, Zhang W, Kang C; ''Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.''; Lab Invest, 2010 PubMedEurope PMCScholia
Yang Z, Bian C, Zhou H, Huang S, Wang S, Liao L, Zhao RC; ''MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1.''; Stem Cells Dev, 2011 PubMedEurope PMCScholia
Strickland MR, Holtzman DM; ''Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.''; J Clin Invest, 2019 PubMedEurope PMCScholia
Abdelmohsen K, Hutchison ER, Lee EK, Kuwano Y, Kim MM, Masuda K, Srikantan S, Subaran SS, Marasa BS, Mattson MP, Gorospe M; ''miR-375 inhibits differentiation of neurites by lowering HuD levels.''; Mol Cell Biol, 2010 PubMedEurope PMCScholia
Avila J; ''Tau phosphorylation and aggregation in Alzheimer's disease pathology.''; FEBS Lett, 2006 PubMedEurope PMCScholia
Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH; ''Neurotoxicity induces cleavage of p35 to p25 by calpain.''; Nature, 2000 PubMedEurope PMCScholia
Small DH, Mok SS, Bornstein JC; ''Alzheimer's disease and Abeta toxicity: from top to bottom.''; Nat Rev Neurosci, 2001 PubMedEurope PMCScholia
Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M; ''Induction of neuronal death by ER stress in Alzheimer's disease.''; J Chem Neuroanat, 2004 PubMedEurope PMCScholia
Dickson DW; ''Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?''; J Clin Invest, 2004 PubMedEurope PMCScholia
Palomer E, Buechler J, Salinas PC; ''Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.''; Front Cell Neurosci, 2019 PubMedEurope PMCScholia
Takuma K, Yan SS, Stern DM, Yamada K; ''Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.''; J Pharmacol Sci, 2005 PubMedEurope PMCScholia
Gandy S; ''The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.''; J Clin Invest, 2005 PubMedEurope PMCScholia
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