Endothelin pathways (Homo sapiens)
From WikiPathways
Description
Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation.
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Ontology Terms
Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AC | GeneProduct | ENSG00000143199 (Ensembl Human) | adenylate cyclase |
ATP | Metabolite | HMDB01532 (HMDB) | |
Arachidonic acid | Metabolite | HMDB01043 (HMDB) | |
Big ET1 | Protein | ||
CAD | GeneProduct | ENSG00000084774 (Ensembl Human) |
|
CGRP | GeneProduct | ENSG00000110680 (Ensembl Human) | |
COX2 | GeneProduct | 4513 (Entrez Gene) | |
CRLR | GeneProduct | ENSG00000064989 (Ensembl Human) | |
Ca2+ channel | Protein | ||
Ca2+ channel | GeneProduct | ||
Ca2+ | Metabolite | HMDB00464 (HMDB) | |
CaM | GeneProduct | ENSG00000198668 (Ensembl Human) | |
Cap | GeneProduct | ENSG00000130176 (Ensembl Human) |
|
Citrulline | Metabolite | HMDB00904 (HMDB) | |
DAG | Metabolite | HMDB07008 (HMDB) | |
ECE | GeneProduct | ENSG00000117298 (Ensembl Human) | |
EDHF | Protein | ||
EDNRA | GeneProduct | ENSG00000151617 (Ensembl Human) | |
EDNRB | GeneProduct | ENSG00000136160 (Ensembl Human) | |
ERK1/2 | GeneProduct | ENSG00000100030 (Ensembl Human) | |
Endothelin 1 | GeneProduct | ENSG00000078401 (Ensembl Human) | |
Furin-like protease | Protein | ||
GTP | Metabolite | HMDB01440 (HMDB) | |
GaI | GeneProduct | ENSG00000127955 (Ensembl Human) | |
GaQ | GeneProduct | ENSG00000060558 (Ensembl Human) | |
GaS | GeneProduct | ENSG00000087460 (Ensembl Human) | |
GbI | GeneProduct | ENSG00000069966 (Ensembl Human) | |
GbQ | GeneProduct | ENSG00000069966 (Ensembl Human) | |
GbS | GeneProduct | ENSG00000069966 (Ensembl Human) | |
GgI | GeneProduct | ENSG00000127588 (Ensembl Human) | |
GgQ | GeneProduct | ENSG00000127588 (Ensembl Human) | |
GgS | GeneProduct | ENSG00000127588 (Ensembl Human) | |
IP1 | GeneProduct | ENSG00000160013 (Ensembl Human) | Prostaglandin I2 Receptor |
IP3 | Metabolite | HMDB01059 (HMDB) | |
IP3R | Protein | ||
K+ channel | Protein | ||
K+ | Metabolite | HMDB00586 (HMDB) | |
L-Arginine | Metabolite | HMDB00517 (HMDB) | |
MEK | GeneProduct | ENSG00000169032 (Ensembl Human) | |
MLC | GeneProduct | ENSG00000168530 (Ensembl Human) | myosine light chain |
MLCK | GeneProduct | ENSG00000065534 (Ensembl Human) | |
NO | Metabolite | HMDB03378 (HMDB) | |
NPY | GeneProduct | ENSG00000122585 (Ensembl Human) | |
PGI2 | Metabolite | ||
PIP2 | Metabolite | HMDB10032 (HMDB) | |
PKA | GeneProduct | ENSG00000178796 (Ensembl Human) | |
PKC | GeneProduct | ENSG00000154229 (Ensembl Human) | |
PLCb | GeneProduct | ENSG00000182621 (Ensembl Human) | |
PMCA | Protein | ||
Pre-pro ET1 | Protein | ||
RAF | GeneProduct | ENSG00000132155 (Ensembl Human) | |
RAMP1 | GeneProduct | ENSG00000132329 (Ensembl Human) | |
SERCA | GeneProduct | ENSG00000174437 (Ensembl Human) | |
Y1 | GeneProduct | ENSG00000164128 (Ensembl Human) | |
a adrenergic receptor | GeneProduct | ENSG00000120907 (Ensembl Human) | |
b adrenergic receptor | GeneProduct | ENSG00000043591 (Ensembl Human) | |
cAMP | Metabolite | HMDB00058 | |
cGMP | Metabolite | HMDB01314 | |
eNOS | GeneProduct | ENSG00000164867 (Ensembl Human) | |
sGC | GeneProduct | ENSG00000123201 (Ensembl Human) |
Annotated Interactions
No annotated interactions