Spinal cord injury (Homo sapiens)

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404LTB4CSPG4PDYNLTB4RTNFSF13BPLXNA2NGFRPTPRZ1LTBNOTNFSF13CD471914283Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimeImmediate Response Genes21Pro-InflammatoryFactorsZFP36FCGR2APRB1PTPRAIL1BZFP36NOS2TNFNR4A1IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5CXCL1Neutrophil ChemoattractantsIL86, 15NeurtrophilsMonocytesAQP4TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating22Activated Microglia/Macrophages(Transient)RepairIL1BNOS2TNFARG1TOXIC FERROUSIRONFocal Adensions9, 27EPHA4TTEPHNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)21CCNG121MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP941TTChondroitin Sulfate Proteoglycans31NCANSLIT1Axon RetractionSLIT231SLIT3NTN1RGMATTTTTTTTTTMMP9MMP941MMP94141TTTTTTCCR2IL1R1TT15ECM BreakdownECM BreakdownIL1ACXCL1Monocyte Chemoattractants6, 15CXCL2CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA138TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion FactorsICAM137SELPTTTTPlasticityKLK8TT7MicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAPTT41IntermediateFillament2CDK4TACR1E2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationCASP3TP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition2IgG, IgMTP5318TTTTTTGRIN1VIM14TT17T Cell StimulatingFK50622PPP3CA32TTFK506FK5063333GAP43TTFK50633Axonal RegenerationFKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB35MyelinInjury ResponseArachidonic acidPGH2PTGS225TT2020ROSNOX4MIR23BOlomoucine36CDK1GDNF11TTSEMA6A3TTAxonal GrowthInhibitionGJA128ATP-ReleaseTTBDNFTT


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
135135view21:23, 6 August 2024EweitzOntology Term : 'neutrophil' added !
135134view21:21, 6 August 2024EweitzOntology Term : 'oligodendrocyte' added !
135133view21:21, 6 August 2024EweitzOntology Term : 'macrophage' added !
130893view00:28, 31 May 2024EweitzOntology Term : 'spinal cord motor neuron' added !
130892view00:27, 31 May 2024EweitzOntology Term : 'motor neuron' added !
130891view00:25, 31 May 2024EweitzOntology Term : 'B cell' added !
130890view00:25, 31 May 2024EweitzOntology Term : 'T cell' added !
130889view00:25, 31 May 2024EweitzOntology Term : 'microglial cell' added !
130888view00:24, 31 May 2024EweitzOntology Term : 'monocyte' added !
120812view15:03, 11 January 2022SusanOntology Term : 'neurological disorder pathway' added !
117177view09:56, 18 May 2021EweitzModified title
106712view13:15, 17 September 2019MaintBotHMDB identifier normalization
105820view23:01, 15 August 2019KhanspersModified description
104858view14:59, 20 June 2019DeSlRemoved weird signs in lit. ref (part 1)
104853view14:52, 20 June 2019DeSlUpdated empty lit. ref
104850view14:46, 20 June 2019DeSlCOnnected unconnected lines.
104843view14:33, 20 June 2019DeSlChanged lines for motor neuron to graphical lines.
101932view12:38, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
87678view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84650view22:21, 10 March 2016Khanspersupdated mmp12 xref
80343view18:15, 9 June 2015Khanspersupdated color and type for MIR23B
79963view13:55, 28 April 2015Zaricorected annotation PTGS2 from chimpanzee to human, annotated Ros
79931view12:14, 27 April 2015EveloRenamed IL8 with the new official HGNC name CXCL8
78556view10:31, 7 January 2015MaintBotadded missing graphIds
76332view08:13, 2 July 2014MkutmonFixed annotation for C5
74098view22:56, 29 March 2014Ariuttaupdate arrowhead
69988view22:03, 11 July 2013MaintBotupdating to 2013 schema
59143view00:06, 22 February 2013DMicaelSpecify description
59080view21:55, 21 February 2013MaintBotUpdated Ensembl data source
58412view22:54, 12 February 2013NsalomonisSpecify description
58411view22:50, 12 February 2013DMicaelSpecify description
58410view22:46, 12 February 2013NsalomonisSpecify description
58380view21:35, 12 February 2013DMicaelPeriodical save, work in progress
58378view21:15, 12 February 2013DMicaelPeriodical save, work in progress
58373view20:23, 12 February 2013DMicaelSpecify description
58370view19:52, 12 February 2013DMicaelPeriodical save, work in progress
58349view16:11, 12 February 2013NsalomonisSpecify description
58322view04:15, 12 February 2013NsalomonisSpecify description
58321view04:14, 12 February 2013NsalomonisSpecify description
58317view23:46, 11 February 2013DMicaelPeriodical save, work in progress
58315view23:15, 11 February 2013DMicaelPeriodical save, work in progress
58313view23:05, 11 February 2013DMicaelPeriodical save, work in progress
58309view22:33, 11 February 2013DMicaelPeriodical save, work in progress
58305view22:02, 11 February 2013DMicaelPeriodical save, work in progress
58304view21:42, 11 February 2013DMicaelSpecify description
58303view21:40, 11 February 2013DMicaelSpecify description
58302view21:39, 11 February 2013DMicaelSpecify description
58301view21:32, 11 February 2013DMicaelPeriodical save, work in progress
58297view21:02, 11 February 2013DMicaelPeriodical save, work in progress
58296view20:42, 11 February 2013DMicaelPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACANGeneProductENSG00000157766 (Ensembl Human)
ANXA1GeneProductENSG00000135046 (Ensembl Human)
AQP4GeneProductENSG00000171885 (Ensembl Human)
ARG1GeneProductENSG00000118520 (Ensembl Human)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
BCANGeneProductENSG00000132692 (Ensembl Human)
BDNFGeneProductENSG00000176697 (Ensembl Human)
BTG2GeneProductENSG00000159388 (Ensembl Human)
C5GeneProductENSG00000106804 (CTD Gene)
CASP3GeneProductENSG00000164305 (Ensembl Human)
CCL2GeneProductENSG00000108691 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CCNG1GeneProductENSG00000113328 (Ensembl Human)
CCR2GeneProductENSG00000121807 (Ensembl Human)
CD47GeneProductENSG00000196776 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK2GeneProductENSG00000123374 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CHST11GeneProductENSG00000171310 (Ensembl Human)
COL2A1GeneProductENSG00000139219 (Ensembl Human)
COL4A1GeneProductENSG00000187498 (Ensembl Human)
CSPG4GeneProductENSG00000173546 (Ensembl Human)
CXCL10GeneProductENSG00000169245 (Ensembl Human)
CXCL1GeneProductENSG00000163739 (Ensembl Human)
CXCL2GeneProductENSG00000081041 (Ensembl Human)
E2F1GeneProductENSG00000101412 (Ensembl Human)
E2F5GeneProductENSG00000133740 (Ensembl Human)
EGR1GeneProductENSG00000120738 (Ensembl Human)
EPHA4GeneProductENSG00000116106 (Ensembl Human)
EPHNB2GeneProductENSG00000125266 (Ensembl Human)
FBRGeneProduct
FCGR2AGeneProductENSG00000143226 (Ensembl Human)
FK506Metabolite104987-11-3 (CAS)
FKBP1AGeneProductENSG00000088832 (Ensembl Human)
FOSGeneProductENSG00000170345 (Ensembl Human)
GADD45AGeneProductENSG00000116717 (Ensembl Human)
GAP43GeneProductENSG00000172020 (Ensembl Human)
GDNFGeneProductENSG00000168621 (Ensembl Human)
GFAPGeneProductENSG00000131095 (Ensembl Human)
GJA1GeneProductENSG00000152661 (Ensembl Human)
GRIN1GeneProductENSG00000176884 (Ensembl Human)
ICAM1GeneProductENSG00000090339 (Ensembl Human)
IFNGGeneProductENSG00000111537 (Ensembl Human)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProductENSG00000125538 (Ensembl Human)
IL1R1GeneProductENSG00000115594 (Ensembl Human)
IL2GeneProductENSG00000109471 (Ensembl Human)
IL4GeneProductENSG00000113520 (Ensembl Human)
IL6GeneProductENSG00000136244 (Ensembl Human)
IL8GeneProductENSG00000169429 (Ensembl Human)
KLK8GeneProductENSG00000129455 (Ensembl Human)
LILRB3GeneProductENSG00000204577 (Ensembl Human)
LTB4Metabolite169 (PubChem)
LTB4RGeneProductENSG00000213903 (Ensembl Human)
LTBGeneProductENSG00000227507 (Ensembl Human)
MAGGeneProductENSG00000105695 (Ensembl Human)
MAPK1GeneProductENSG00000100030 (Ensembl Human)
MAPK3GeneProduct
MBPGeneProductENSG00000197971 (Ensembl Human)
MIR23BGeneProductENSG00000207563 (Ensembl Human)
MMP12GeneProductENSG00000110347 (Ensembl Human)
MMP9GeneProductENSG00000100985 (Ensembl Human)
MYCGeneProductENSG00000136997 (Ensembl Human)
NCANGeneProductENSG00000130287 (Ensembl Human)
NGFRGeneProductENSG00000064300 (Ensembl Human)
NOMetabolite145068 (PubChem)
NOS1GeneProductENSG00000089250 (Ensembl Human)
NOS2GeneProductENSG00000007171 (Ensembl Human)
NOX4GeneProductENSG00000086991 (Ensembl Human)
NR4A1GeneProductENSG00000123358 (Ensembl Human)
NTN1GeneProductENSG00000065320 (Ensembl Human)
OMGGeneProductENSG00000126861 (Ensembl Human)
OlomoucineMetaboliteHMDB35233 (HMDB)
PDYNGeneProductENSG00000101327 (Ensembl Human)
PGH2MetaboliteHMDB01381 (HMDB)
PLA2G2AGeneProductENSG00000188257 (Ensembl Human)
PLA2G5GeneProductENSG00000127472 (Ensembl Human)
PLA2G6GeneProductENSG00000184381 (Ensembl Human)
PLXNA2GeneProductENSG00000076356 (Ensembl Human)
PPP3CAGeneProductENSG00000138814 (Ensembl Human)
PRB1GeneProductENSG00000251655 (Ensembl Human)
PRKCAGeneProductENSG00000154229 (Ensembl Human)
PTGS2GeneProduct469616 (Entrez Gene)
PTPRAGeneProductENSG00000132670 (Ensembl Human)
PTPRZ1GeneProductENSG00000106278 (Ensembl Human)
RB1GeneProductENSG00000139687 (Ensembl Human)
RGMAGeneProductENSG00000182175 (Ensembl Human)
RHOAGeneProductENSG00000067560 (Ensembl Human)
RHOBGeneProductENSG00000143878 (Ensembl Human)
RHOCGeneProductENSG00000155366 (Ensembl Human)
ROCK2GeneProductENSG00000134318 (Ensembl Human)
ROSGeneProduct
RTN4GeneProductENSG00000115310 (Ensembl Human)
RTN4RGeneProductENSG00000040608 (Ensembl Human)
SELPGeneProductENSG00000174175 (Ensembl Human)
SEMA6AGeneProductENSG00000092421 (Ensembl Human)
SLIT1GeneProductENSG00000187122 (Ensembl Human)
SLIT2GeneProductENSG00000145147 (Ensembl Human)
SLIT3GeneProductENSG00000184347 (Ensembl Human)
SOX9GeneProductENSG00000125398 (Ensembl Human)
TACR1GeneProductENSG00000115353 (Ensembl Human)
TGFB1GeneProductENSG00000105329 (Ensembl Human)
TLR4GeneProductENSG00000136869 (Ensembl Human)
TNFGeneProductENSG00000232810 (Ensembl Human)
TNFSF13BGeneProductENSG00000102524 (Ensembl Human)
TNFSF13GeneProductENSG00000161955 (Ensembl Human)
TP53GeneProductENSG00000141510 (Ensembl Human)
VCANGeneProductENSG00000038427 (Ensembl Human)
VIMGeneProductENSG00000026025 (Ensembl Human)
XYLT1GeneProductENSG00000103489 (Ensembl Human)
ZFP36GeneProductENSG00000128016 (Ensembl Human)
melittinMetabolite16133648 (PubChem)

Annotated Interactions

No annotated interactions

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