Metapathway biotransformation (Mus musculus)

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ReductionHydrolysisNucleophilesN-acetyltransferasesCytochrome P450Amino acid conjugationElectrophilesGlutathione synthetaseGlutathione transferasesGlucuronidationAcetylationEpoxide hydrolasesOxidationGlutathione reductaseGlutathione conjugationMethyltransferasesGlucuronosyltransferasesSulfotransferasesMethylationSulfationAldo-keto reductasesFlavin monooxygenasesGlutathione peroxidasesAmino acid acyl transferasesUGT1A10Kcnab2Cyp4v3Hs3st2CYP2C9UGT1A6Nat9Gstk1Cyp39a1CYP4F8AKR1C3HS3ST3A1Cyp26b1BaatChst1Ndst2Cyp24a1Substrate=OCyp2s1Sult4a1Chst5Substrate-AcCYP11B1Chst3UGT2A2Cyp8b1GssKcnab1Gstt2GstcdGSTA2AC122521.4Ugt2a2Gstz1CYP3A5GSTA4Cyp11a1HnmtMgst1Gpx2Fmo3Hs6st1GSTA5Cyp1a1CYP3A43Cyp2u1AC161058.2-1UGT1A5Gal3st1Chst5Substrate-NH2NAT1Fmo2HS3ST3B1Hs6st3CYP4F11Ephx1Cyp7a1Cyp26c1CYP2C19SulfotransferaseGSTM1Amino acid acyltransferaseGpx5SULT1C2Gstm7CYP11B2Gstt1Gal3st3Substrate-SO3HAC140307.3-1Hs6st2Nat12Chst10Chst7Ugt1a1NAT8CYP27C1Comt1UGT2B15AC154274.1-1Substrate-SGNdst3GAL3ST2AKR1C1Chst4Mgst3Chst8Gpx1Sult2b1Sult1a1GLYATL2Cyp46a1Cyp2e1Cyp21a1CYP450Cyp51Fmo4GSTA3CYP2B6InmtNAT2Substrate-O-RXenobiotic substrateTpmtUgt2a3Gpx4Sult1a1Gstt2Gal3st4UGT2B17Nat6Mgst2CYP4F12CYP2A7Chst2Gpx3Flavin monooxygenaseSubstrate-GlGlyatCyp26a1Glutathione transferaseGSTM4Substrate-AaCYP2A6Akr7a5Sult1a1Sult1e1Cyp1b1Substrate-OHChst9Cyp1a2SULT1C3GLYATL1GSTP1Cyp4f18GlucuronosyltransferaseChst11UGT2B4Gsto2Hs3st4Hs2st1GsrCyp2r1UGT1A7Hs3st1Nat5Cyp27a1CYP3A4Chst12Ephx2Ugt1a10Cyp20a1Hs3st6CYP2A13Cyp7b1Cyp4b1SULT1C4Gstm5Cyp2f2N-acetyltransferaseGsto1Fmo1Ndst1Cyp4x1GSTM5Substrate-SHUGT2B7UGT2B11Hs3st5CYP2C18AKR7A3CYP2D6Cyp19a1Fmo5Sult1b1Sult1a1UGT1A9CYP2C8Nat8lCyp17a1Nat14Ugt1a5Substrate-CH3Aldo-keto reductaseNat10Chst14Kcnab3Akr1b3CYP4F2Ndst4SULT2A1CYP2J2AKR1B10Cyp4f39AKR1C2Akr1d1AKR1C4GSTA1CYP3A7Akr1a4Sult1c2CYP4Z1Cyp27b1Ugt1a2NnmtUGT2B28Nat13Methyltransferase


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP702(r29945) with a 64% conversion rate.

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View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
94721view14:08, 5 October 2017EgonwConverted two complexes (which they are not) to groups.
94720view14:04, 5 October 2017EgonwMim-typed interactions.
69747view09:37, 11 July 2013EgonwAdded ChEBI identifiers for a few compound classes.
69160view18:19, 8 July 2013MaintBotUpdated to 2013 gpml schema
67456view11:04, 26 June 2013DdiglesOntology Term : 'cellular detoxification pathway' added !
59060view21:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58513view19:13, 14 February 2013MaintBotModified title
41349view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
34408view23:07, 9 December 2009MaintBotAutomatic update of empty xrefs
33190view18:06, 5 November 2009KhanspersModified categories
32293view13:12, 15 August 2009MaintBotFixed text labels
31856view12:33, 14 August 2009MaintBotFixed group labels
31321view20:17, 13 August 2009MaintBotFixed text labels
30847view00:06, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC122521.4GeneProductENSMUSG00000056643 (Ensembl Mouse)
AC140307.3-1GeneProductENSMUSG00000024764 (Ensembl Mouse)
AC154274.1-1GeneProductENSMUSG00000038045 (Ensembl Mouse)
AC161058.2-1GeneProductENSMUSG00000029541 (Ensembl Mouse)
AKR1B10GeneProduct67861 (Entrez Gene)
AKR1C1GeneProduct
AKR1C2GeneProduct
AKR1C3GeneProduct
AKR1C4GeneProduct
AKR7A3GeneProduct
Akr1a4GeneProductENSMUSG00000028692 (Ensembl Mouse)
Akr1b3GeneProductENSMUSG00000001642 (Ensembl Mouse)
Akr1d1GeneProductENSMUSG00000038641 (Ensembl Mouse)
Akr7a5GeneProductENSMUSG00000028743 (Ensembl Mouse)
Aldo-keto reductaseGeneProduct
Amino acid acyltransferaseGeneProduct
BaatGeneProductENSMUSG00000039653 (Ensembl Mouse)
CYP11B1GeneProduct110115 (Entrez Gene)
CYP11B2GeneProduct13072 (Entrez Gene)
CYP27C1GeneProduct
CYP2A13GeneProduct
CYP2A6GeneProduct
CYP2A7GeneProduct
CYP2B6GeneProduct
CYP2C18GeneProduct
CYP2C19GeneProduct
CYP2C8GeneProduct
CYP2C9GeneProduct
CYP2D6GeneProduct
CYP2J2GeneProduct
CYP3A4GeneProduct
CYP3A43GeneProduct
CYP3A5GeneProduct
CYP3A7GeneProduct
CYP450GeneProduct
CYP4F11GeneProduct
CYP4F12GeneProduct
CYP4F2GeneProduct
CYP4F8GeneProduct
CYP4Z1GeneProduct
Chst10GeneProductENSMUSG00000026080 (Ensembl Mouse)
Chst11GeneProductENSMUSG00000034612 (Ensembl Mouse)
Chst12GeneProductENSMUSG00000036599 (Ensembl Mouse)
Chst14GeneProduct72136 (Entrez Gene)
Chst1GeneProductENSMUSG00000027221 (Ensembl Mouse)
Chst2GeneProductENSMUSG00000033350 (Ensembl Mouse)
Chst3GeneProductENSMUSG00000057337 (Ensembl Mouse)
Chst4GeneProductENSMUSG00000035930 (Ensembl Mouse)
Chst5GeneProductENSMUSG00000031952 (Ensembl Mouse)
Chst7GeneProductENSMUSG00000037347 (Ensembl Mouse)
Chst8GeneProductENSMUSG00000060402 (Ensembl Mouse)
Chst9GeneProduct71367 (Entrez Gene)
Comt1GeneProductENSMUSG00000000326 (Ensembl Mouse)
Cyp11a1GeneProductENSMUSG00000032323 (Ensembl Mouse)
Cyp17a1GeneProductENSMUSG00000003555 (Ensembl Mouse)
Cyp19a1GeneProductENSMUSG00000032274 (Ensembl Mouse)
Cyp1a1GeneProductENSMUSG00000032315 (Ensembl Mouse)
Cyp1a2GeneProductENSMUSG00000032310 (Ensembl Mouse)
Cyp1b1GeneProductENSMUSG00000024087 (Ensembl Mouse)
Cyp20a1GeneProductENSMUSG00000049439 (Ensembl Mouse)
Cyp21a1GeneProduct13079 (Entrez Gene)
Cyp24a1GeneProductENSMUSG00000038567 (Ensembl Mouse)
Cyp26a1GeneProductENSMUSG00000024987 (Ensembl Mouse)
Cyp26b1GeneProductENSMUSG00000063415 (Ensembl Mouse)
Cyp26c1GeneProductENSMUSG00000062432 (Ensembl Mouse)
Cyp27a1GeneProductENSMUSG00000026170 (Ensembl Mouse)
Cyp27b1GeneProductENSMUSG00000006724 (Ensembl Mouse)
Cyp2e1GeneProductENSMUSG00000025479 (Ensembl Mouse)
Cyp2f2GeneProductENSMUSG00000052974 (Ensembl Mouse)
Cyp2r1GeneProductENSMUSG00000030670 (Ensembl Mouse)
Cyp2s1GeneProductENSMUSG00000040703 (Ensembl Mouse)
Cyp2u1GeneProductENSMUSG00000027983 (Ensembl Mouse)
Cyp39a1GeneProductENSMUSG00000023963 (Ensembl Mouse)
Cyp46a1GeneProductENSMUSG00000021259 (Ensembl Mouse)
Cyp4b1GeneProductENSMUSG00000028713 (Ensembl Mouse)
Cyp4f18GeneProductENSMUSG00000003484 (Ensembl Mouse)
Cyp4f39GeneProductENSMUSG00000061126 (Ensembl Mouse)
Cyp4v3GeneProductENSMUSG00000079057 (Ensembl Mouse)
Cyp4x1GeneProductENSMUSG00000047155 (Ensembl Mouse)
Cyp51GeneProductENSMUSG00000001467 (Ensembl Mouse)
Cyp7a1GeneProductENSMUSG00000028240 (Ensembl Mouse)
Cyp7b1GeneProductENSMUSG00000039519 (Ensembl Mouse)
Cyp8b1GeneProductENSMUSG00000050445 (Ensembl Mouse)
Ephx1GeneProductENSMUSG00000038776 (Ensembl Mouse)
Ephx2GeneProductENSMUSG00000022040 (Ensembl Mouse)
Flavin monooxygenaseGeneProduct
Fmo1GeneProductENSMUSG00000040181 (Ensembl Mouse)
Fmo2GeneProductENSMUSG00000040170 (Ensembl Mouse)
Fmo3GeneProductENSMUSG00000026691 (Ensembl Mouse)
Fmo4GeneProductENSMUSG00000026692 (Ensembl Mouse)
Fmo5GeneProductENSMUSG00000028088 (Ensembl Mouse)
GAL3ST2GeneProduct381334 (Entrez Gene)
GLYATL1GeneProduct
GLYATL2GeneProduct
GSTA1GeneProduct14857 (Entrez Gene)
GSTA2GeneProduct14858 (Entrez Gene)
GSTA3GeneProduct14859 (Entrez Gene)
GSTA4GeneProduct14860 (Entrez Gene)
GSTA5GeneProduct
GSTM1GeneProduct14862 (Entrez Gene)
GSTM4GeneProduct14865 (Entrez Gene)
GSTM5GeneProduct14866 (Entrez Gene)
GSTP1GeneProduct14870 (Entrez Gene)
Gal3st1GeneProductENSMUSG00000049721 (Ensembl Mouse)
Gal3st3GeneProductENSMUSG00000047658 (Ensembl Mouse)
Gal3st4GeneProductENSMUSG00000075593 (Ensembl Mouse)
GlucuronosyltransferaseGeneProduct
Glutathione transferaseGeneProduct
GlyatGeneProductENSMUSG00000063683 (Ensembl Mouse)
Gpx1GeneProductENSMUSG00000063856 (Ensembl Mouse)
Gpx2GeneProductENSMUSG00000042808 (Ensembl Mouse)
Gpx3GeneProductENSMUSG00000018339 (Ensembl Mouse)
Gpx4GeneProductENSMUSG00000075706 (Ensembl Mouse)
Gpx5GeneProductENSMUSG00000004344 (Ensembl Mouse)
GsrGeneProductENSMUSG00000031584 (Ensembl Mouse)
GssGeneProductENSMUSG00000027610 (Ensembl Mouse)
GstcdGeneProductENSMUSG00000028018 (Ensembl Mouse)
Gstk1GeneProductENSMUSG00000029864 (Ensembl Mouse)
Gstm5GeneProductENSMUSG00000004032 (Ensembl Mouse)
Gstm7GeneProductENSMUSG00000004035 (Ensembl Mouse)
Gsto1GeneProductENSMUSG00000025068 (Ensembl Mouse)
Gsto2GeneProductENSMUSG00000025069 (Ensembl Mouse)
Gstt1GeneProductENSMUSG00000001663 (Ensembl Mouse)
Gstt2GeneProductENSMUSG00000033318 (Ensembl Mouse)
Gstz1GeneProductENSMUSG00000021033 (Ensembl Mouse)
HS3ST3A1GeneProduct15478 (Entrez Gene)
HS3ST3B1GeneProduct54710 (Entrez Gene)
HnmtGeneProductENSMUSG00000026986 (Ensembl Mouse)
Hs2st1GeneProductENSMUSG00000040151 (Ensembl Mouse)
Hs3st1GeneProductENSMUSG00000051022 (Ensembl Mouse)
Hs3st2GeneProductENSMUSG00000046321 (Ensembl Mouse)
Hs3st4GeneProductENSMUSG00000078591 (Ensembl Mouse)
Hs3st5GeneProductENSMUSG00000044499 (Ensembl Mouse)
Hs3st6GeneProductENSMUSG00000039628 (Ensembl Mouse)
Hs6st1GeneProductENSMUSG00000045216 (Ensembl Mouse)
Hs6st2GeneProductENSMUSG00000062184 (Ensembl Mouse)
Hs6st3GeneProductENSMUSG00000053465 (Ensembl Mouse)
InmtGeneProductENSMUSG00000003477 (Ensembl Mouse)
Kcnab1GeneProductENSMUSG00000027827 (Ensembl Mouse)
Kcnab2GeneProductENSMUSG00000028931 (Ensembl Mouse)
Kcnab3GeneProductENSMUSG00000018470 (Ensembl Mouse)
MethyltransferaseGeneProduct
Mgst1GeneProductENSMUSG00000008540 (Ensembl Mouse)
Mgst2GeneProductENSMUSG00000074604 (Ensembl Mouse)
Mgst3GeneProductENSMUSG00000026688 (Ensembl Mouse)
N-acetyltransferaseGeneProduct
NAT1GeneProduct
NAT2GeneProduct17961 (Entrez Gene)
NAT8GeneProduct68396 (Entrez Gene)
Nat10GeneProductENSMUSG00000027185 (Ensembl Mouse)
Nat12GeneProductENSMUSG00000036282 (Ensembl Mouse)
Nat13GeneProductENSMUSG00000022698 (Ensembl Mouse)
Nat14GeneProductENSMUSG00000035285 (Ensembl Mouse)
Nat5GeneProductENSMUSG00000002728 (Ensembl Mouse)
Nat6GeneProductENSMUSG00000079334 (Ensembl Mouse)
Nat8lGeneProductENSMUSG00000048142 (Ensembl Mouse)
Nat9GeneProductENSMUSG00000015542 (Ensembl Mouse)
Ndst1GeneProductENSMUSG00000054008 (Ensembl Mouse)
Ndst2GeneProductENSMUSG00000039308 (Ensembl Mouse)
Ndst3GeneProductENSMUSG00000027977 (Ensembl Mouse)
Ndst4GeneProductENSMUSG00000027971 (Ensembl Mouse)
NnmtGeneProductENSMUSG00000032271 (Ensembl Mouse)
SULT1C2GeneProduct69083 (Entrez Gene)
SULT1C3GeneProduct
SULT1C4GeneProduct
SULT2A1GeneProduct20859 (Entrez Gene)
Substrate-AaMetabolite
Substrate-AcMetabolite
Substrate-CH3Metabolite
Substrate-GlMetabolite
Substrate-NH2Metabolite
Substrate-O-RMetabolite
Substrate-OHMetabolite
Substrate-SGMetabolite
Substrate-SHMetabolite
Substrate-SO3HMetabolite
Substrate=OMetabolite
SulfotransferaseGeneProduct
Sult1a1GeneProductENSMUSG00000030711 (Ensembl Mouse)
Sult1b1GeneProductENSMUSG00000029269 (Ensembl Mouse)
Sult1c2GeneProductENSMUSG00000023122 (Ensembl Mouse)
Sult1e1GeneProductENSMUSG00000029272 (Ensembl Mouse)
Sult2b1GeneProductENSMUSG00000003271 (Ensembl Mouse)
Sult4a1GeneProductENSMUSG00000018865 (Ensembl Mouse)
TpmtGeneProductENSMUSG00000021376 (Ensembl Mouse)
UGT1A10GeneProduct394430 (Entrez Gene)
UGT1A5GeneProduct394433 (Entrez Gene)
UGT1A6GeneProduct
UGT1A7GeneProduct
UGT1A9GeneProduct394434 (Entrez Gene)
UGT2A2GeneProduct552899 (Entrez Gene)
UGT2B11GeneProduct
UGT2B15GeneProduct
UGT2B17GeneProduct
UGT2B28GeneProduct
UGT2B4GeneProduct
UGT2B7GeneProduct
Ugt1a10GeneProductENSMUSG00000054545 (Ensembl Mouse)
Ugt1a1GeneProduct394436 (Entrez Gene)
Ugt1a2GeneProduct22236 (Entrez Gene)
Ugt1a5GeneProduct394433 (Entrez Gene)
Ugt2a2GeneProductENSMUSG00000029268 (Ensembl Mouse)
Ugt2a3GeneProductENSMUSG00000035780 (Ensembl Mouse)
Xenobiotic substrateMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1251"
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