DNA replication (Drosophila melanogaster)

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1, 2RNA PrimerMcm 4,6,7 trimer forms and associatesPre-replicative complexUTPMcm2Degraded by proteasome in cytosolHOMOLOGY MAPPMcm6RFC140Mcm10RNA primer-DNA primer1. Assembly of the pre-replicative complexOrc2Orc complexPCNA homotrimerMcm5Orc complexOrc5with the replication forkDegraded by proteasome in cytosolProcessive complex5. Leading/lagging strand synthesisRFC37Cdt1Mcm3GemininMcm7RNA primer-DNA primeraRNA primer-DNA primer:origin duplex:PCNAp58Phosphorylation of Mcm 2-7 complexDNA PolymeraseOrc4ATPUbiquitinMcm5Orc3dCTPMcm3dGTPCdt1Phosphorylated Cdc6Orc ComplexADPCdt1Ubiquitinated Cdc6RFC38UbiquitinGTPOrc complexADP3. DNA replication initiationDNA polymerase alpha: primase: origin complexdUTP4. Switching of origins to post-replicative statePre-replicative complexCdc6Orc5Cdc62. Activation of the pre-replicative complexPrimasep70Mcm7Mcm4RFC40Cdc6RFC36Mcm6Orc2CTPOrc2Orc complexOrc2Orc3ATPCdt1Orc3Mcm2RFC Heteropentamer:RNA primer-DNA primerDNA polymerase alpha: primase: origin complexCdt1ATPOrc5p49Phosphorylated Orc1dATPATPOrc4p180Mcm4Orc3Cdc6RFC Heteropentamer:RNA primer-DNA primer:Ubiquitinated Orc1Orc1OriginRfC38RpA-70RPA3RpL40CG5971RfC40Mcm6CDC45LOrc4dpaASKOrc5Mcm10RPA4Ubi-p63ECG8142DNApol-alpha73l(1)G0148CG12018DNApol-epsilonMcm7latdupmus209Orc1POLD3Mcm2DNApol-alpha50Mcm3DNApol-alpha180RfC3DNApol-deltaPole2CG9273Gnf1GMNNOrc2POLD4CDK2DNAprimMcm5Orc6


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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